vipadenant [Ligand Id: 5612] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL447664 (Vipadenant, CEB-4520, VER-ADO-49, V2006, VER-A-00-11, VER-A-00049, BIIB-014, VER-A00049, VER-11135, V-2006, VER-A00-11)
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
1 CHEMBL447664_lig_chart_1 Adenosine A1 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
2 CHEMBL447664_lig_chart_2 Adenosine A2a receptor Human
There should be some charts here, you may need to enable JavaScript!
  • A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
3 CHEMBL447664_lig_chart_3 Adenosine A2b receptor Human
There should be some charts here, you may need to enable JavaScript!
  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
4 CHEMBL447664_lig_chart_4 Adenosine A3 receptor Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Antagonist activity at human adenosine A1 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay F 7 pKd 100 nM Kd J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
ChEMBL Displacement of radioligand from human recombinant adenosine A1 receptor at 21 degC after 90 mins by cell-based microplate scintillation counting B 7.17 pKi 68 nM Ki J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
ChEMBL Inhibition of human recombinant adenosine A1 receptor B 7.17 pKi 68 nM Ki J. Med. Chem. (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb - - 7.17 pKi 68 nM Ki J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Antagonist activity at human adenosine A2A receptor expressed in CHO-K1 cells treated for 15 mins by calcium mobilization-based FLIPR assay F 9.2 pKd 0.63 nM Kd J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
ChEMBL Displacement of radioligand from human recombinant adenosine A2A receptor at 21 degC after 90 mins by cell-based microplate scintillation counting B 8.89 pKi 1.3 nM Ki J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
ChEMBL Inhibition of human recombinant adenosine receptor A2a F 8.89 pKi 1.3 nM Ki J. Med. Chem. (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb - - 8.89 pKi 1.3 nM Ki J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
ChEMBL Antagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay F 7.5 pKd 31.62 nM Kd J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
GtoPdb - - 7.2 pKi 63 nM Ki J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
ChEMBL Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting B 7.2 pKi 63 nM Ki J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
ChEMBL Inhibition of human recombinant adenosine receptor A2b B 7.2 pKi 63 nM Ki J. Med. Chem. (2014) 57: 3623-3650 [PMID:24164628]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Antagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay F 5.8 pKd 1584.89 nM Kd J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
ChEMBL Displacement of radioligand from human recombinant adenosine A3 receptor at 21 degC after 60 mins by cell-based microplate scintillation counting B 6 pKi 1005 nM Ki J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]
ChEMBL Inhibition of human recombinant adenosine A3 receptor B 6 pKi 1005 nM Ki J. Med. Chem. (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb - - 6 pKi 1005 nM Ki J. Med. Chem. (2009) 52: 33-47 [PMID:19072055]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]