brensocatib [Ligand Id: 9412] activity data from GtoPdb

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  • cathepsin C in Human [GtoPdb: 2344] [UniProtKB: P53634]
  • cathepsin C in Mouse [GtoPdb: 2344] [UniProtKB: P97821]
  • cathepsin C in Rat [GtoPdb: 2344] [UniProtKB: P80067]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin C in Human [GtoPdb: 2344] [UniProtKB: P53634]
GtoPdb Surface plasmon resonance direct binding assay - 8.6 pKd 2.5 nM Kd J. Med. Chem. (2016) 59: 9457-9472 [PMID:27690432]
GtoPdb In vitro enzyme assay - 8.4 pIC50 3.98 nM IC50 J. Med. Chem. (2016) 59: 9457-9472 [PMID:27690432]
cathepsin C in Mouse [GtoPdb: 2344] [UniProtKB: P97821]
GtoPdb In vitro enzyme assay - 7.6 pIC50 25.1 nM IC50 J. Med. Chem. (2016) 59: 9457-9472 [PMID:27690432]
cathepsin C in Rat [GtoPdb: 2344] [UniProtKB: P80067]
GtoPdb In vitro enzyme assay - 7.7 pIC50 19.9 nM IC50 J. Med. Chem. (2016) 59: 9457-9472 [PMID:27690432]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.