perampanel   Click here for help

GtoPdb Ligand ID: 7050

Synonyms: E2007 | ER-155055-90 | Fycompa®
Approved drug PDB Ligand
perampanel is an approved drug (FDA and EMA (2012))
Compound class: Synthetic organic
Comment: Perampanel is an anticonvulsant. The drug is administered as perampanel hydrate.
It is first and only FDA-approved non-competitive AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 58.16
Molecular weight 349.12
XLogP 5.29
No. Lipinski's rules broken 1
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Canonical SMILES N#Cc1ccccc1c1cc(cn(c1=O)c1ccccc1)c1ccccn1
Isomeric SMILES N#Cc1ccccc1c1cc(cn(c1=O)c1ccccc1)c1ccccn1
InChI InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA and EMA (2012))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
8834 perampanel
Synonyms Click here for help
E2007 | ER-155055-90 | Fycompa®
Database Links Click here for help
CAS Registry No. 380917-97-5
ChEMBL Ligand CHEMBL1214124
DrugBank Ligand DB08883
DrugCentral Ligand 4684
GtoPdb PubChem SID 178103629
PubChem CID 9924495
Search Google for chemical match using the InChIKey PRMWGUBFXWROHD-UHFFFAOYSA-N
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UniChem Compound Search for chemical match using the InChIKey PRMWGUBFXWROHD-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey PRMWGUBFXWROHD-UHFFFAOYSA-N
Wikipedia Perampanel