perampanel   Click here for help

GtoPdb Ligand ID: 7050

Synonyms: E2007 | ER-155055-90 | Fycompa®
Approved drug PDB Ligand
perampanel is an approved drug (FDA and EMA (2012))
Compound class: Synthetic organic
Comment: Perampanel is an anticonvulsant. The drug is administered as perampanel hydrate.
It is first and only FDA-approved non-competitive AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 58.16
Molecular weight 349.12
XLogP 5.29
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES N#Cc1ccccc1c1cc(cn(c1=O)c1ccccc1)c1ccccn1
Isomeric SMILES N#Cc1ccccc1c1cc(cn(c1=O)c1ccccc1)c1ccccn1
InChI InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
InChI Key PRMWGUBFXWROHD-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA and EMA (2012))
IUPAC Name Click here for help
2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile
International Nonproprietary Names Click here for help
INN number INN
8834 perampanel
Synonyms Click here for help
E2007 | ER-155055-90 | Fycompa®
Database Links Click here for help
CAS Registry No. 380917-97-5
ChEMBL Ligand CHEMBL1214124
DrugBank Ligand DB08883
DrugCentral Ligand 4684
GtoPdb PubChem SID 178103629
PubChem CID 9924495
RCSB PDB Ligand 6ZP
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Wikipedia Perampanel