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ChEMBL ligand: CHEMBL3361425 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
ChEMBL | Displacement of [3H]DPDPE from human DOR expressed in HEK293 cells after 60 mins by scintillation counting analysis | B | 5.6 | pKi | 2486 | nM | Ki | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Displacement of [3H]U-69593 from human KOR expressed in HEK293 cells after 60 mins by scintillation counting analysis | B | 6.65 | pKi | 224 | nM | Ki | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]DAMGO from human MOR expressed in HEK293 cells after 60 mins by scintillation counting analysis | B | 6.7 | pKi | 201 | nM | Ki | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
NPFF1 receptor/Neuropeptide FF receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5951] [GtoPdb: 300] [UniProtKB: Q9GZQ6] | ||||||||
GtoPdb | Binding affinity. | - | 7.09 | pKi | 81 | nM | Ki | J Med Chem (2014) 57: 8903-27 [PMID:25268943] |
ChEMBL | Displacement of [3H]NPVF from human NPFF1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis | B | 7.09 | pKi | 81 | nM | Ki | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
ChEMBL | Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to control | F | 5.45 | pEC50 | 3520 | nM | EC50 | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
NPFF2 receptor/Neuropeptide FF receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5952] [GtoPdb: 301] [UniProtKB: Q9Y5X5] | ||||||||
ChEMBL | Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis | B | 5.85 | pKi | 1426 | nM | Ki | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
GtoPdb | Binding affinity. | - | 5.85 | pKi | 1426 | nM | Ki | J Med Chem (2014) 57: 8903-27 [PMID:25268943] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]