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ChEMBL ligand: CHEMBL107955 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
ChEMBL | Inhibition of f10a | B | 5.77 | pKi | 1700 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
Coagulation factor X in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3656] [UniProtKB: P00743] | ||||||||
ChEMBL | Compound was tested for inhibition of Coagulation factor X | B | 5.77 | pKi | 1700 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
ST14 transmembrane serine protease matriptase /Matriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6] | ||||||||
ChEMBL | Inhibition of matriptase | B | 6.49 | pKi | 320 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952] | ||||||||
ChEMBL | Compound was tested for inhibition of plasma kallikrein | B | 5.14 | pKi | 7200 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] | ||||||||
GtoPdb | - | - | 5.84 | pKi | 1460 | nM | Ki | Thromb Haemost (2005) 93: 779-86 [PMID:15841327] |
ChEMBL | Compound was tested for inhibition of plasmin | B | 6.41 | pKi | 390 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
ChEMBL | Inhibition of plasmin | B | 6.41 | pKi | 390 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
ChEMBL | Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry | B | 6.41 | pKi | 390 | nM | Ki | Bioorg Med Chem (2012) 20: 1557-1568 [PMID:22285569] |
ChEMBL | Inhibition of human plasmin | B | 6.41 | pKi | 390 | nM | Ki | J Med Chem (2020) 63: 1445-1472 [PMID:31658420] |
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
GtoPdb | - | - | 6.3 | pKi | 500 | nM | Ki | Thromb Haemost (2005) 93: 779-86 [PMID:15841327] |
ChEMBL | Compound was tested for inhibition of thrombin | B | 6.31 | pKi | 490 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
ChEMBL | Inhibition of thrombin | B | 6.31 | pKi | 490 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
ChEMBL | Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry | B | 6.31 | pKi | 490 | nM | Ki | Bioorg Med Chem (2012) 20: 1557-1568 [PMID:22285569] |
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] | ||||||||
ChEMBL | Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry | B | 5.31 | pKi | 4900 | nM | Ki | Bioorg Med Chem (2012) 20: 1557-1568 [PMID:22285569] |
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760] | ||||||||
ChEMBL | Compound was tested for inhibition of trypsin | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
tryptase gamma 1/Tryptase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4955] [GtoPdb: 2425] [UniProtKB: Q9NRR2] | ||||||||
ChEMBL | Compound was tested for inhibition of tryptase | B | 5.2 | pKi | 6300 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749] | ||||||||
GtoPdb | - | - | 6.19 | pKi | 650 | nM | Ki | Thromb Haemost (2005) 93: 779-86 [PMID:15841327] |
ChEMBL | Compound was tested for inhibition of plasminogen activator urokinase (microPa) | B | 6.39 | pKi | 410 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
ChEMBL | Inhibition of uPA | B | 6.39 | pKi | 410 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
ChEMBL | Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry | B | 6.39 | pKi | 410 | nM | Ki | Bioorg Med Chem (2012) 20: 1557-1568 [PMID:22285569] |
ChEMBL | Inhibition of uPA (unknown origin) | B | 6.39 | pKi | 410 | nM | Ki | J Med Chem (2015) 58: 9238-9257 [PMID:26575094] |
ChEMBL | Inhibition of uPA | B | 6.39 | pIC50 | 410 | nM | IC50 | J Med Chem (2008) 51: 183-186 [PMID:18163548] |
GtoPdb | - | - | 6.4 | pIC50 | 410 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 3147-52 [PMID:10560742] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]