Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL107955 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
ChEMBL | Inhibition of f10a | B | 5.77 | pKi | 1700 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
Coagulation factor X in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3656] [UniProtKB: P00743] | ||||||||
ChEMBL | Compound was tested for inhibition of Coagulation factor X | B | 5.77 | pKi | 1700 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
ST14 transmembrane serine protease matriptase /Matriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6] | ||||||||
ChEMBL | Inhibition of matriptase | B | 6.49 | pKi | 320 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952] | ||||||||
ChEMBL | Compound was tested for inhibition of plasma kallikrein | B | 5.14 | pKi | 7200 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] | ||||||||
GtoPdb | - | - | 5.84 | pKi | 1460 | nM | Ki | Thromb Haemost (2005) 93: 779-86 [PMID:15841327] |
ChEMBL | Compound was tested for inhibition of plasmin | B | 6.41 | pKi | 390 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
ChEMBL | Inhibition of plasmin | B | 6.41 | pKi | 390 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
ChEMBL | Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry | B | 6.41 | pKi | 390 | nM | Ki | Bioorg Med Chem (2012) 20: 1557-1568 [PMID:22285569] |
ChEMBL | Inhibition of human plasmin | B | 6.41 | pKi | 390 | nM | Ki | J Med Chem (2020) 63: 1445-1472 [PMID:31658420] |
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
GtoPdb | - | - | 6.3 | pKi | 500 | nM | Ki | Thromb Haemost (2005) 93: 779-86 [PMID:15841327] |
ChEMBL | Compound was tested for inhibition of thrombin | B | 6.31 | pKi | 490 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
ChEMBL | Inhibition of thrombin | B | 6.31 | pKi | 490 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
ChEMBL | Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry | B | 6.31 | pKi | 490 | nM | Ki | Bioorg Med Chem (2012) 20: 1557-1568 [PMID:22285569] |
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] | ||||||||
ChEMBL | Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry | B | 5.31 | pKi | 4900 | nM | Ki | Bioorg Med Chem (2012) 20: 1557-1568 [PMID:22285569] |
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760] | ||||||||
ChEMBL | Compound was tested for inhibition of trypsin | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
tryptase gamma 1/Tryptase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4955] [GtoPdb: 2425] [UniProtKB: Q9NRR2] | ||||||||
ChEMBL | Compound was tested for inhibition of tryptase | B | 5.2 | pKi | 6300 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749] | ||||||||
GtoPdb | - | - | 6.19 | pKi | 650 | nM | Ki | Thromb Haemost (2005) 93: 779-86 [PMID:15841327] |
ChEMBL | Compound was tested for inhibition of plasminogen activator urokinase (microPa) | B | 6.39 | pKi | 410 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3147-3152 [PMID:10560742] |
ChEMBL | Inhibition of uPA | B | 6.39 | pKi | 410 | nM | Ki | J Med Chem (2006) 49: 4116-4126 [PMID:16821772] |
ChEMBL | Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry | B | 6.39 | pKi | 410 | nM | Ki | Bioorg Med Chem (2012) 20: 1557-1568 [PMID:22285569] |
ChEMBL | Inhibition of uPA (unknown origin) | B | 6.39 | pKi | 410 | nM | Ki | J Med Chem (2015) 58: 9238-9257 [PMID:26575094] |
ChEMBL | Inhibition of uPA | B | 6.39 | pIC50 | 410 | nM | IC50 | J Med Chem (2008) 51: 183-186 [PMID:18163548] |
GtoPdb | - | - | 6.4 | pIC50 | 410 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 3147-52 [PMID:10560742] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]