ChEMBL ligand: CHEMBL266195 (Alprenolol, NSC-759561)
β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] There should be some charts here, you may need to enable JavaScript!
β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] Beta-2 adrenergic receptor in Bovine [ChEMBL: CHEMBL3373] [UniProtKB: Q28044] There should be some charts here, you may need to enable JavaScript!
β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	F	6.75	pKd	177.83	nM	Kd	J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cells	B	7.95	pKd	11.22	nM	Kd	J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	F	8.37	pKd	4.27	nM	Kd	J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart.	B	8.31	pIC50	4.88	nM	IC50	J. Med. Chem. (1982) 25: 931-936 [PMID:6126588]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL	Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis	B	8.84	pKd	1.45	nM	Kd	J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
ChEMBL	Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis	B	8.84	pKd	1.45	nM	Kd	J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
ChEMBL	Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis	B	9.1	pKd	0.79	nM	Kd	ACS Med. Chem. Lett. (2013) 4: 1005-1010 [PMID:24454993]
ChEMBL	Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cells	B	9.3	pKd	0.5	nM	Kd	J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	F	9.53	pKd	0.3	nM	Kd	J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
ChEMBL	Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
GtoPdb	-	-	9	pKi	-	-	-	Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]
ChEMBL	Displacement of [3H]-CGP12177 from human recombinant beta2 adrenoceptor expressed in CHOK1 cells after 1.5 hrs by scintillation counting analysis	B	9	pKi	1	nM	Ki	ACS Med. Chem. Lett. (2013) 4: 1005-1010 [PMID:24454993]
ChEMBL	Displacement of [3H](-)CGP 12177 from human recombinant beta2 adrenoceptor after 120 mins by scintillation counting method	B	9.3	pKi	0.5	nM	Ki	MedChemComm (2019) 10: 974-984 [PMID:31303996]
ChEMBL	Antagonist activity at beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 30 mins by TR-FRET assay	F	8.26	pIC50	5.5	nM	IC50	J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
ChEMBL	Antagonist activity at human recombinant beta2 adrenoreceptor expressed in CHOK1 cells incubated for 30 mins by HTRF	B	8.48	pIC50	3.3	nM	IC50	MedChemComm (2019) 10: 974-984 [PMID:31303996]
ChEMBL	Antagonist activity at beta2 adrenergic receptor (unknown origin) expressed in HEK293 cell assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 15 mins	F	8.94	pIC50	1.15	nM	IC50	J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
ChEMBL	Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.	B	8.53	pIC50	2.98	nM	IC50	J. Med. Chem. (1982) 25: 931-936 [PMID:6126588]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL	Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells	B	6.86	pKd	138.04	nM	Kd	J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	F	7.12	pKd	75.86	nM	Kd	J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Displacement of [3H]-OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter method	B	7.67	pKi	21.6	nM	Ki	MedChemComm (2019) 10: 974-984 [PMID:31303996]
ChEMBL	Antagonist activity at human 5HT1A expressed in BAF3 cells by fluorimetry analysis	B	6.2	pIC50	630	nM	IC50	MedChemComm (2019) 10: 974-984 [PMID:31303996]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement	B	6.93	pKi	117.49	nM	Ki	J. Med. Chem. (1996) 39: 126-134 [PMID:8568799]
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
ChEMBL	Inhibition of rat microsomal squalene synthase	B	5.38	pIC50	4200	nM	IC50	J. Med. Chem. (1995) 38: 4157-4160 [PMID:7473541]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]