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ChEMBL ligand: CHEMBL266195 (Alprenolol, NSC-759561) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
ChEMBL | Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 6.75 | pKd | 177.83 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cells | B | 7.95 | pKd | 11.22 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 8.37 | pKd | 4.27 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart. | B | 8.31 | pIC50 | 4.88 | nM | IC50 | J Med Chem (1982) 25: 931-936 [PMID:6126588] |
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
ChEMBL | Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis | B | 8.84 | pKd | 1.45 | nM | Kd | J Med Chem (2019) 62: 7806-7839 [PMID:31298548] |
ChEMBL | Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis | B | 8.84 | pKd | 1.45 | nM | Kd | J Med Chem (2019) 62: 7806-7839 [PMID:31298548] |
ChEMBL | Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis | B | 9.1 | pKd | 0.79 | nM | Kd | ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993] |
ChEMBL | Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cells | B | 9.3 | pKd | 0.5 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 9.53 | pKd | 0.3 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (2019) 62: 7806-7839 [PMID:31298548] |
ChEMBL | Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (2019) 62: 7806-7839 [PMID:31298548] |
GtoPdb | - | - | 9 | pKi | - | - | - | Br J Pharmacol (2005) 144: 317-22 [PMID:15655528] |
ChEMBL | Displacement of [3H]-CGP12177 from human recombinant beta2 adrenoceptor expressed in CHOK1 cells after 1.5 hrs by scintillation counting analysis | B | 9 | pKi | 1 | nM | Ki | ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993] |
ChEMBL | Displacement of [3H](-)CGP 12177 from human recombinant beta2 adrenoceptor after 120 mins by scintillation counting method | B | 9.3 | pKi | 0.5 | nM | Ki | Medchemcomm (2019) 10: 974-984 [PMID:31303996] |
ChEMBL | Antagonist activity at beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 30 mins by TR-FRET assay | F | 8.26 | pIC50 | 5.5 | nM | IC50 | J Med Chem (2019) 62: 7806-7839 [PMID:31298548] |
ChEMBL | Antagonist activity at human recombinant beta2 adrenoreceptor expressed in CHOK1 cells incubated for 30 mins by HTRF | B | 8.48 | pIC50 | 3.3 | nM | IC50 | Medchemcomm (2019) 10: 974-984 [PMID:31303996] |
ChEMBL | Antagonist activity at beta2 adrenergic receptor (unknown origin) expressed in HEK293 cell assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 15 mins | F | 8.94 | pIC50 | 1.15 | nM | IC50 | J Med Chem (2019) 62: 7806-7839 [PMID:31298548] |
Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044] | ||||||||
ChEMBL | Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes. | B | 8.53 | pIC50 | 2.98 | nM | IC50 | J Med Chem (1982) 25: 931-936 [PMID:6126588] |
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
ChEMBL | Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells | B | 6.86 | pKd | 138.04 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 7.12 | pKd | 75.86 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Displacement of [3H]-OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter method | B | 7.67 | pKi | 21.6 | nM | Ki | Medchemcomm (2019) 10: 974-984 [PMID:31303996] |
ChEMBL | Antagonist activity at human 5HT1A expressed in BAF3 cells by fluorimetry analysis | B | 6.2 | pIC50 | 630 | nM | IC50 | Medchemcomm (2019) 10: 974-984 [PMID:31303996] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
ChEMBL | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement | B | 6.93 | pKi | 117.49 | nM | Ki | J Med Chem (1996) 39: 126-134 [PMID:8568799] |
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
ChEMBL | Inhibition of rat microsomal squalene synthase | B | 5.38 | pIC50 | 4200 | nM | IC50 | J Med Chem (1995) 38: 4157-4160 [PMID:7473541] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]