alprenolol [Ligand Id: 563] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL266195 (Alprenolol)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • Beta-2 adrenergic receptor in Bovine [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis F 6.75 pKd 177.83 nM Kd J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cells B 7.95 pKd 11.22 nM Kd J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis F 8.37 pKd 4.27 nM Kd J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart. B 8.31 pIC50 4.88 nM IC50 J. Med. Chem. (1982) 25: 931-936 [PMID:6126588]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis B 8.84 pKd 1.45 nM Kd J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
ChEMBL Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis B 8.84 pKd 1.45 nM Kd J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
ChEMBL Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis B 9.1 pKd 0.79 nM Kd ACS Med. Chem. Lett. (2013) 4: 1005-1010 [PMID:24454993]
ChEMBL Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cells B 9.3 pKd 0.5 nM Kd J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis F 9.53 pKd 0.3 nM Kd J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis B 8.92 pKi 1.2 nM Ki J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
ChEMBL Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis B 8.92 pKi 1.2 nM Ki J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
GtoPdb - - 9 pKi - - - Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]
ChEMBL Displacement of [3H]-CGP12177 from human recombinant beta2 adrenoceptor expressed in CHOK1 cells after 1.5 hrs by scintillation counting analysis B 9 pKi 1 nM Ki ACS Med. Chem. Lett. (2013) 4: 1005-1010 [PMID:24454993]
ChEMBL Displacement of [3H](-)CGP 12177 from human recombinant beta2 adrenoceptor after 120 mins by scintillation counting method B 9.3 pKi 0.5 nM Ki MedChemComm (2019) 10: 974-984
ChEMBL Antagonist activity at beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 30 mins by TR-FRET assay B 8.26 pIC50 5.5 nM IC50 J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
ChEMBL Antagonist activity at human recombinant beta2 adrenoreceptor expressed in CHOK1 cells incubated for 30 mins by HTRF B 8.48 pIC50 3.3 nM IC50 MedChemComm (2019) 10: 974-984
ChEMBL Antagonist activity at beta2 adrenergic receptor (unknown origin) expressed in HEK293 cell assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 15 mins B 8.94 pIC50 1.15 nM IC50 J Med Chem (2019) 62: 7806-7839 [PMID:31298548]
Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
ChEMBL Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes. B 8.53 pIC50 2.98 nM IC50 J. Med. Chem. (1982) 25: 931-936 [PMID:6126588]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells B 6.86 pKd 138.04 nM Kd J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis F 7.12 pKd 75.86 nM Kd J. Med. Chem. (2011) 54: 6874-6887 [PMID:21870877]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Displacement of [3H]-OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter method B 7.67 pKi 21.6 nM Ki MedChemComm (2019) 10: 974-984
ChEMBL Antagonist activity at human 5HT1A expressed in BAF3 cells by fluorimetry analysis B 6.2 pIC50 630 nM IC50 MedChemComm (2019) 10: 974-984
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement B 6.93 pKi 117.49 nM Ki J. Med. Chem. (1996) 39: 126-134 [PMID:8568799]
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
ChEMBL Inhibition of rat microsomal squalene synthase B 5.38 pIC50 4200 nM IC50 J. Med. Chem. (1995) 38: 4157-4160 [PMID:7473541]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]