ChEMBL ligand: CHEMBL10557
Sortase A in S.aureus [ChEMBL: CHEMBL5362] [UniProtKB: Q9S446] There should be some charts here, you may need to enable JavaScript!
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7] There should be some charts here, you may need to enable JavaScript!
Tubulin beta chain in Bovine [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856] There should be some charts here, you may need to enable JavaScript!
Pyruvate carboxylase in Human [GtoPdb: 1262] [UniProtKB: P11498] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Sortase A in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5362] [UniProtKB: Q9S446]
ChEMBL	Inhibition of wild type recombinant Staphylococcus aureus ATCC 25904 Sortase A expressed in Escherichia coli BL21 using Dabcyl-QALPETGEE-Edans as substrate incubated for 30 mins followed by substrate addition and measured after 60 mins by FRET assay	B	4.18	pIC50	65700	nM	IC50	J Med Chem (2021) 64: 13097-13130 [PMID:34516107]
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7]
ChEMBL	Inhibition of tubulin polymerization in Homo sapiens (human) solid tumor cells	B	5.48	pIC50	3311.31	nM	IC50	Med Chem Res (2013) 22: 3229-3241
Tubulin beta chain in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856]
ChEMBL	Inhibition of tubulin polymerization	F	6.2	pIC50	630	nM	IC50	J Med Chem (1994) 37: 1126-1135 [PMID:8164254]
Pyruvate carboxylase in Human [GtoPdb: 1262] [UniProtKB: P11498]
GtoPdb	Inhibition of pyruvate carboxylase in human HCCLM3 cell lysate	-	8.29	pIC50	5.18	nM	IC50	J Med Chem (2022) 65: 460-484 [PMID:34931827]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]