tazobactam [Ligand Id: 10789] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL404 (CL 298,741, CL-298741, NSC-759887, Tazobactam, YTR-830H) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Bacterial beta-lactamase TEM in Bacteria (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2364670] [UniProtKB: P62593] | ||||||||
| ChEMBL | Inhibition of bacterial N-terminal His-tagged TEV protease site linked TEM-1 (24 to 286 amino acids) expressed in Escherichia coli Transetta (DE3) preincubated for 10 mins followed by FC5 fluorescent substrate addition by fluorescence assay | B | 6.72 | pKi | 190 | nM | Ki | J Med Chem (2019) 62: 7160-7184 [PMID:31269398] |
| ChEMBL | Cell Free Inhibition Assay: The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by determining the concentration of inhibitor at which 50% of the nitrocefin hydrolysis is inhibited by the particular enzyme. Assays are performed with beta -lactamases expressed in the pET system (Novagen, San Diego, Calif.) without signal peptides. They contain an N-terminal hexa-Histidine tag that is used for purification on Ni-NTA (Qiagen, Hilden, Germany). The compounds are prepared as 50 mM stocks in DMSO and diluted into buffer P1 (50 mM phosphate, pH 7) to a final concentration of 10% DMSO. All further dilutions are done in P2 (P1 with 10% DMSO). Enzyme and compound dilutions are pre-incubated for 10 min at 37 C. and the reaction is started with the addition of pre-warmed (37 C.) nitrocefin at a final concentration of 50 mM. The change in absorption at 490 nm is followed at 37 C. for 10 min with 30 s intervals. | B | 7.76 | pIC50 | 17.2 | nM | IC50 | US-9120808-B2. Substituted clavulanic acid (2015) |
| Beta-lactamase in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3885668] [UniProtKB: D2SSQ3] | ||||||||
| ChEMBL | Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2 | B | 5.7 | pIC50 | 2000 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 533-535 [PMID:19884378] |
| Beta-lactamase in Citrobacter freundii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255130] [UniProtKB: P05193] | ||||||||
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Citrobacter freundii 1982 | B | 6.03 | pIC50 | 930 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| Beta-lactamase in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2725] [UniProtKB: P05364] | ||||||||
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Ent. cloacae 6300 | B | 4.07 | pIC50 | 85000 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Inhibition of Enterobacter cloacae AmpC | B | 4.08 | pIC50 | 84000 | nM | IC50 | J. Med. Chem. (2006) 49: 4623-4637 [PMID:16854068] |
| ChEMBL | In vitro inhibitory activity against Beta-lactamase AmpC of class C enzyme | B | 4.32 | pIC50 | 48000 | nM | IC50 | J. Med. Chem. (2003) 46: 2569-2571 [PMID:12801220] |
| ChEMBL | Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae | B | 5.11 | pIC50 | 7700 | nM | IC50 | Bioorg. Med. Chem. Lett. (2000) 10: 2179-2182 [PMID:11012024] |
| ChEMBL | Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae SC 12368 E-2 | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg. Med. Chem. Lett. (1995) 5: 1513-1518 |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Enterobacter cloacae 908R | B | 5.72 | pIC50 | 1900 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Inhibition of Enterobacter cloacae AmpC | B | 5.74 | pIC50 | 1808 | nM | IC50 | J. Med. Chem. (2007) 50: 4113-4121 [PMID:17665896] |
| ChEMBL | Inhibition of Enterobacter cloacae beta-lactamase P99 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation | B | 5.89 | pIC50 | 1300 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 5132-5138 [PMID:20921316] |
| ChEMBL | Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae P99 | B | 6.03 | pIC50 | 943 | nM | IC50 | Bioorg. Med. Chem. Lett. (1995) 5: 1513-1518 |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from SHV-2 | B | 6.03 | pIC50 | 930 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase fromOXA-2 | F | 6.08 | pIC50 | 830 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from PSE-1 | B | 6.25 | pIC50 | 560 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from RTEM-2 | B | 6.25 | pIC50 | 560 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from RTEM-1 | B | 6.38 | pIC50 | 420 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from OXA-1 | B | 6.62 | pIC50 | 240 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from RTEM-3 | B | 6.82 | pIC50 | 150 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | In vitro inhibitory activity against Beta-lactamase TEM-1 of class A enzyme | B | 7 | pIC50 | 100 | nM | IC50 | J. Med. Chem. (2003) 46: 2569-2571 [PMID:12801220] |
| Beta-lactamase in Morganella morganii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5764] [UniProtKB: P94958] | ||||||||
| ChEMBL | Compound was tested for inhibition of beta-Lactamases from Morganell morgani U1627 | B | 6.72 | pIC50 | 190 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| Beta-lactamase in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4114] [UniProtKB: P00807] | ||||||||
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Staphylococcus aureus PCI | B | 6.3 | pIC50 | 500 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| Beta-lactamase in Bacillus licheniformis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5633] [UniProtKB: P00808] | ||||||||
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Bacillus licheniformis 749/C | B | 6.29 | pIC50 | 510 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| Beta-lactamase in Pseudomonas luteola (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308938] [UniProtKB: Q670S6] | ||||||||
| ChEMBL | Inhibition of Pseudomonas luteola LAM Beta-lactamase LUT-1 | B | 7.4 | pIC50 | 40 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 45-51 [PMID:19884377] |
| Beta-lactamase in Bacillus clausii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5439] [UniProtKB: A8RR46] | ||||||||
| ChEMBL | Inhibition of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | B | 8.4 | pIC50 | 4 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 4009-4014 [PMID:17846134] |
| Beta-lactamase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5031] [UniProtKB: P24735] | ||||||||
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Pseudomonas aeruginosa MK-1184 | B | 4.44 | pIC50 | 36000 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Inhibition of Pseudomonas aeruginosa beta-lactamase AmpC assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation | B | 5.34 | pIC50 | 4600 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 5132-5138 [PMID:20921316] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Pseudomonas aeruginosa GN10362 | B | 5.68 | pIC50 | 2110 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Pseudomonas aeruginosa 18SH | B | 6.09 | pIC50 | 820 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| Beta-lactamase AmpC in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2026] [UniProtKB: P00811] | ||||||||
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Bacteroides fragilis 98 | B | 4.01 | pIC50 | 98000 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | In vitro inhibitory activity against Class C (Amp-C) beta-Lactamases | B | 4.08 | pIC50 | 84000 | nM | IC50 | J. Med. Chem. (2004) 47: 3674-3688 [PMID:15214794] |
| ChEMBL | In vitro inhibitory concentration against AmpC enzyme | B | 4.32 | pIC50 | 48000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2001) 11: 997-1000 [PMID:11327608] |
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Escherichia coli SN03 | B | 4.74 | pIC50 | 18000 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| ChEMBL | Cell Free Inhibition Assay: The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by determining the concentration of inhibitor at which 50% of the nitrocefin hydrolysis is inhibited by the particular enzyme. Assays are performed with beta -lactamases expressed in the pET system (Novagen, San Diego, Calif.) without signal peptides. They contain an N-terminal hexa-Histidine tag that is used for purification on Ni-NTA (Qiagen, Hilden, Germany). The compounds are prepared as 50 mM stocks in DMSO and diluted into buffer P1 (50 mM phosphate, pH 7) to a final concentration of 10% DMSO. All further dilutions are done in P2 (P1 with 10% DMSO). Enzyme and compound dilutions are pre-incubated for 10 min at 37 C. and the reaction is started with the addition of pre-warmed (37 C.) nitrocefin at a final concentration of 50 mM. The change in absorption at 490 nm is followed at 37 C. for 10 min with 30 s intervals. | B | 5.74 | pIC50 | 1808.2 | nM | IC50 | US-9120808-B2. Substituted clavulanic acid (2015) |
| ChEMBL | Inhibitory activity against class A TEM-1 beta-lactamase | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg. Med. Chem. Lett. (2002) 12: 1663-1666 [PMID:12039585] |
| Beta-lactamase bla(BEL1) in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3885670] [UniProtKB: Q3SAW3] | ||||||||
| ChEMBL | Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1 | B | 5.7 | pIC50 | 2000 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 533-535 [PMID:19884378] |
| Beta-lactamase CTX-M in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6131] [UniProtKB: Q9EXV5] | ||||||||
| ChEMBL | Inhibition of Escherichia coli CTX-M-15 | B | 8.7 | pIC50 | 2 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 3089-3095 [PMID:17591851] |
| Beta-lactamase GES-13 in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250341] [UniProtKB: D1MIX9] | ||||||||
| ChEMBL | Inhibition of Pseudomonas aeruginosa GES-13 beta lactamase | B | 7.22 | pIC50 | 60 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 1331-1333 [PMID:20065056] |
| Beta-lactamase OXA-1 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4951] [UniProtKB: P13661] | ||||||||
| ChEMBL | Compound was tested for inhibition of Beta-lactamase from Bacteroides fragilis 36 | F | 5.32 | pIC50 | 4800 | nM | IC50 | J. Med. Chem. (1996) 39: 3712-3722 [PMID:8809160] |
| Beta-lactamase SCO-1 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075073] [UniProtKB: A1E3K9] | ||||||||
| ChEMBL | Inhibition of Escherichia coli beta-lactamase SCO1 | B | 8 | pIC50 | 10 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 2185-2188 [PMID:17353248] |
| Beta-lactamase SHV-1 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5956] [UniProtKB: P0AD63] | ||||||||
| ChEMBL | Inhibition of Escherichia coli SHV1 | B | 6.65 | pIC50 | 222 | nM | IC50 | J. Med. Chem. (2007) 50: 4113-4121 [PMID:17665896] |
| ChEMBL | Cell Free Inhibition Assay: The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by determining the concentration of inhibitor at which 50% of the nitrocefin hydrolysis is inhibited by the particular enzyme. Assays are performed with beta -lactamases expressed in the pET system (Novagen, San Diego, Calif.) without signal peptides. They contain an N-terminal hexa-Histidine tag that is used for purification on Ni-NTA (Qiagen, Hilden, Germany). The compounds are prepared as 50 mM stocks in DMSO and diluted into buffer P1 (50 mM phosphate, pH 7) to a final concentration of 10% DMSO. All further dilutions are done in P2 (P1 with 10% DMSO). Enzyme and compound dilutions are pre-incubated for 10 min at 37 C. and the reaction is started with the addition of pre-warmed (37 C.) nitrocefin at a final concentration of 50 mM. The change in absorption at 490 nm is followed at 37 C. for 10 min with 30 s intervals. | B | 6.65 | pIC50 | 222 | nM | IC50 | US-9120808-B2. Substituted clavulanic acid (2015) |
| Beta-lactamase SHV-1 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5094] [UniProtKB: P0AD64] | ||||||||
| ChEMBL | Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1 | B | 6.96 | pIC50 | 110 | nM | IC50 | Antimicrob. Agents Chemother. (2008) 52: 1806-1811 [PMID:18316518] |
| Beta-lactamase SHV-72 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255121] [UniProtKB: A0ZX81] | ||||||||
| ChEMBL | Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-72 | B | 7.1 | pIC50 | 80 | nM | IC50 | Antimicrob. Agents Chemother. (2008) 52: 1806-1811 [PMID:18316518] |
| Beta-lactamase TEM in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3652] [UniProtKB: Q6W9J1] | ||||||||
| ChEMBL | Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg. Med. Chem. Lett. (2000) 10: 2179-2182 [PMID:11012024] |
| Beta-lactamase TEM in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2065] [UniProtKB: P62593] | ||||||||
| ChEMBL | Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-1 | B | 6.89 | pIC50 | 130 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 4181-4183 [PMID:17709463] |
| ChEMBL | Inhibition of Escherichia coli TEM1 | B | 7 | pIC50 | 100 | nM | IC50 | J. Med. Chem. (2006) 49: 4623-4637 [PMID:16854068] |
| ChEMBL | In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases | B | 7 | pIC50 | 100 | nM | IC50 | J. Med. Chem. (2004) 47: 3674-3688 [PMID:15214794] |
| ChEMBL | Inhibition of Escherichia coli K12 TEM1 | B | 7.05 | pIC50 | 90 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 2185-2188 [PMID:17353248] |
| ChEMBL | In vitro inhibitory concentration against TEM-1 enzyme | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg. Med. Chem. Lett. (2001) 11: 997-1000 [PMID:11327608] |
| ChEMBL | Inhibitory activity against beta-Lactamase enzyme derived from Escherichia coli WC3310 TEM-2 | B | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg. Med. Chem. Lett. (1995) 5: 1513-1518 |
| ChEMBL | Inhibition of Escherichia coli TEM1 | B | 7.77 | pIC50 | 17 | nM | IC50 | J. Med. Chem. (2007) 50: 4113-4121 [PMID:17665896] |
| Beta-lactamase TEM-125 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5041] [UniProtKB: Q6GWS8] | ||||||||
| ChEMBL | Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-158 | B | 6.62 | pIC50 | 240 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 4181-4183 [PMID:17709463] |
| Beta-lactamase type II in Bacteroides fragilis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4840] [UniProtKB: P25910] | ||||||||
| ChEMBL | In vitro inhibitory concentration against CCRA enzyme | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2001) 11: 997-1000 [PMID:11327608] |
| Carbapenem-hydrolizing beta-lactamase SFC-1 in Serratia fonticola (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5042] [UniProtKB: Q6JP75] | ||||||||
| ChEMBL | Inhibition of Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGE | B | 5.16 | pIC50 | 6900 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 4512-4514 [PMID:17875998] |
| Carbepenem-hydrolyzing beta-lactamase KPC in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6132] [UniProtKB: Q9F663] | ||||||||
| ChEMBL | Inhibition of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by competitive assay | B | 4.13 | pKi | 74000 | nM | Ki | Antimicrob. Agents Chemother. (2010) 54: 2867-2877 [PMID:20421396] |
| ChEMBL | Inhibition of Klebsiella pneumoniae KPC-1 beta lactamase expressed in Escherichia coli DH5alpha by SDS-PAGE | B | 6.43 | pIC50 | 374 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 4512-4514 [PMID:17875998] |
| ChEMBL | Inhibition of carbapenem-resistant Klebsiella pneumoniae carbepenem-hydrolyzing beta-lactamase KPC-1 | B | 6.43 | pIC50 | 370 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 328-332 [PMID:19901091] |
| Class D beta-lactamase in Brachyspira pilosicoli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255145] [UniProtKB: Q50H31] | ||||||||
| ChEMBL | Inhibition of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as reduction in nitrocefin hydrolysis by spectrophotometry relative to oxacillin | B | 6.8 | pIC50 | 160 | nM | IC50 | Antimicrob. Agents Chemother. (2008) 52: 1264-1268 [PMID:18212108] |
| Extended-spectrum beta-lactamase CTX-M-53 in Salmonella enterica subsp. enterica serovar Westhampton (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667678] [UniProtKB: Q2XPY6] | ||||||||
| ChEMBL | Inhibition of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53 | B | 8.66 | pIC50 | 2.2 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1944-1951 [PMID:19273683] |
| Gil1 in Citrobacter gillenii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075063] [UniProtKB: A4KCT8] | ||||||||
| ChEMBL | Inhibition of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B | B | 7.4 | pIC50 | 40 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 1365-1372 [PMID:17242148] |
| IMI-1 in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5219] [UniProtKB: Q46991] | ||||||||
| ChEMBL | In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases | B | 7.52 | pIC50 | 30 | nM | IC50 | J. Med. Chem. (2004) 47: 3674-3688 [PMID:15214794] |
| ChEMBL | Inhibition of Enterobacter cloacae IMI1 beta lactamase expressed in Escherichia coli DH5alpha by SDS-PAGE | B | 7.52 | pIC50 | 30 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 4512-4514 [PMID:17875998] |
| PenB class A beta-lactamase in Burkholderia cenocepacia (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641339] [UniProtKB: B8R6A5] | ||||||||
| ChEMBL | Inhibition of Burkholderia cenocepacia 07-34 beta-lactamase PenB1 | B | 6.3 | pIC50 | 500 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 876-882 [PMID:19075063] |
| PER-2 beta-lactamase in Citrobacter freundii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5303] [UniProtKB: A2RP81] | ||||||||
| ChEMBL | Inhibition of Citrobacter freundii PER2 beta lactamase | B | 7.02 | pIC50 | 96 | nM | IC50 | Antimicrob. Agents Chemother. (2007) 51: 2359-2365 [PMID:17438050] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]
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