compound 1a [PMID: 15055993] [Ligand Id: 6514] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL61193
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  • MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
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  • MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
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  • MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536]
ChEMBL Inhibition of recombinant human TNF-alpha converting enzyme B 8.64 pKi 2.3 nM Ki Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504]
ChEMBL Inhibition of human tumor necrosis factor alpha converting enzyme B 8.64 pKi 2.3 nM Ki J Med Chem (2004) 47: 1930-1938 [PMID:15055993]
ChEMBL Inhibition of TACE B 8.64 pKi 2.3 nM Ki Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454]
ChEMBL Inhibition of heparin-binding HB-EGF shedding B 6.46 pIC50 350 nM IC50 J Med Chem (2004) 47: 1930-1938 [PMID:15055993]
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL Inhibition of recombinant human matrix metalloprotease-1 B 8.1 pKi 8 nM Ki Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504]
ChEMBL Inhibition of human recombinant matrix metalloprotease 1 B 8.1 pKi 8 nM Ki J Med Chem (2004) 47: 1930-1938 [PMID:15055993]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL Inhibition of recombinant human matrix metalloprotease-3 B 9.29 pKi 0.51 nM Ki Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504]
ChEMBL Inhibition of human recombinant matrix metalloprotease 3 B 9.29 pKi 0.51 nM Ki J Med Chem (2004) 47: 1930-1938 [PMID:15055993]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
GtoPdb - - 10.2 pKi 0.06 nM Ki J Med Chem (2004) 47: 1930-8 [PMID:15055993]
ChEMBL Inhibition of MMP9 B 10.21 pKi 0.06 nM Ki Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454]
ChEMBL Inhibition of recombinant human matrix metalloprotease-9 B 10.22 pKi 0.06 nM Ki Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504]
ChEMBL Inhibition of human recombinant matrix metalloprotease 9 B 10.22 pKi 0.06 nM Ki J Med Chem (2004) 47: 1930-1938 [PMID:15055993]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]