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ChEMBL ligand: CHEMBL61193 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
ChEMBL | Inhibition of recombinant human TNF-alpha converting enzyme | B | 8.64 | pKi | 2.3 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504] |
ChEMBL | Inhibition of human tumor necrosis factor alpha converting enzyme | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
ChEMBL | Inhibition of TACE | B | 8.64 | pKi | 2.3 | nM | Ki | Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454] |
ChEMBL | Inhibition of heparin-binding HB-EGF shedding | B | 6.46 | pIC50 | 350 | nM | IC50 | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
ChEMBL | Inhibition of recombinant human matrix metalloprotease-1 | B | 8.1 | pKi | 8 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504] |
ChEMBL | Inhibition of human recombinant matrix metalloprotease 1 | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
ChEMBL | Inhibition of recombinant human matrix metalloprotease-3 | B | 9.29 | pKi | 0.51 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504] |
ChEMBL | Inhibition of human recombinant matrix metalloprotease 3 | B | 9.29 | pKi | 0.51 | nM | Ki | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
GtoPdb | - | - | 10.2 | pKi | 0.06 | nM | Ki | J Med Chem (2004) 47: 1930-8 [PMID:15055993] |
ChEMBL | Inhibition of MMP9 | B | 10.21 | pKi | 0.06 | nM | Ki | Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454] |
ChEMBL | Inhibition of recombinant human matrix metalloprotease-9 | B | 10.22 | pKi | 0.06 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504] |
ChEMBL | Inhibition of human recombinant matrix metalloprotease 9 | B | 10.22 | pKi | 0.06 | nM | Ki | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]