compound 1a [PMID: 15055993] [Ligand Id: 6514] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL61193 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of recombinant human TNF-alpha converting enzyme | B | 8.64 | pKi | 2.3 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504] |
| ChEMBL | Inhibition of human tumor necrosis factor alpha converting enzyme | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
| ChEMBL | Inhibition of TACE | B | 8.64 | pKi | 2.3 | nM | Ki | Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454] |
| ChEMBL | Inhibition of heparin-binding HB-EGF shedding | B | 6.46 | pIC50 | 350 | nM | IC50 | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of recombinant human matrix metalloprotease-1 | B | 8.1 | pKi | 8 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504] |
| ChEMBL | Inhibition of human recombinant matrix metalloprotease 1 | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of recombinant human matrix metalloprotease-3 | B | 9.29 | pKi | 0.51 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504] |
| ChEMBL | Inhibition of human recombinant matrix metalloprotease 3 | B | 9.29 | pKi | 0.51 | nM | Ki | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| GtoPdb | - | - | 10.2 | pKi | 0.06 | nM | Ki | J Med Chem (2004) 47: 1930-8 [PMID:15055993] |
| ChEMBL | Inhibition of MMP9 | B | 10.21 | pKi | 0.06 | nM | Ki | Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454] |
| ChEMBL | Inhibition of recombinant human matrix metalloprotease-9 | B | 10.22 | pKi | 0.06 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2737-2740 [PMID:12873504] |
| ChEMBL | Inhibition of human recombinant matrix metalloprotease 9 | B | 10.22 | pKi | 0.06 | nM | Ki | J Med Chem (2004) 47: 1930-1938 [PMID:15055993] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
