crisaborole [Ligand Id: 9151] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL484785 (AN-2728, AN2728, Crisaborol, Crisaborole, Eucrisa, Staquis) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 4A/3`,5`-cyclic-AMP phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] | ||||||||
| ChEMBL | Inhibition of PDE4A1A (unknown origin) | B | 7.26 | pIC50 | 55 | nM | IC50 | J Med Chem (2018) 61: 10375-10384 [PMID:30052440] |
| phosphodiesterase 4B/3`,5`-cyclic-AMP phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
| ChEMBL | Inhibition of PDE4B (unknown origin) | B | 4.15 | pIC50 | 70000 | nM | IC50 | Eur J Med Chem (2021) 213: 113171-113171 [PMID:33482600] |
| ChEMBL | Inhibition of human PDE4 catalytic domain expressed in Escherichia coli | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2021) 64: 17706-17727 [PMID:34875836] |
| ChEMBL | Inhibition of PDE4B (unknown origin) assessed as hydrolysis of [3H]-cGMP into [3H]-GMP incubated for 30 mins by scintillation of proximity assay | B | 7.24 | pIC50 | 57.2 | nM | IC50 | Eur J Med Chem (2021) 213: 113171-113171 [PMID:33482600] |
| ChEMBL | Inhibition of PDE4B2 (unknown origin) | B | 7.26 | pIC50 | 55 | nM | IC50 | J Med Chem (2018) 61: 10375-10384 [PMID:30052440] |
| ChEMBL | Inhibition of PDE4B1 (unknown origin) | B | 7.26 | pIC50 | 55 | nM | IC50 | J Med Chem (2018) 61: 10375-10384 [PMID:30052440] |
| phosphodiesterase 4C/3`,5`-cyclic-AMP phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] | ||||||||
| ChEMBL | Inhibition of PDE4C1 (unknown origin) | B | 7.26 | pIC50 | 55 | nM | IC50 | J Med Chem (2018) 61: 10375-10384 [PMID:30052440] |
| phosphodiesterase 4D/3`,5`-cyclic-AMP phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] | ||||||||
| ChEMBL | Inhibition of human PDE4D catalytic domain (T86 to S413 residues) expressed in Escherichia coli BL21 (DE3) using [3H]-cAMP/cGMP as substrate incubated for 10 mins by MicroBeta scintillation proximity assay | B | 5.94 | pIC50 | 1140 | nM | IC50 | J Med Chem (2024) 67: 4855-4869 [PMID:38489246] |
| ChEMBL | Inhibition of PDE4D (unknown origin) | B | 6.31 | pIC50 | 490 | nM | IC50 | J Med Chem (2022) 65: 4238-4254 [PMID:35188767] |
| ChEMBL | Inhibition of PDE4D7 (unknown origin) | B | 7.26 | pIC50 | 55 | nM | IC50 | J Med Chem (2018) 61: 10375-10384 [PMID:30052440] |
| Beta-lactamase in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641358] [UniProtKB: Q93LQ9] | ||||||||
| ChEMBL | Inhibition of Klebsiella pneumoniae KPC-2 | B | 6.17 | pIC50 | 670 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127956-127956 [PMID:33744439] |
| phosphodiesterase 1A/Dual specificity calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750] | ||||||||
| GtoPdb | - | - | 5.21 | pIC50 | 6100 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2129-32 [PMID:19303290] |
| ChEMBL | Inhibition of human recombinant PDE1A3 expressed in baculovirus-infected insect Sf9 cells by modified two-step method | B | 5.21 | pIC50 | 6100 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2129-2132 [PMID:19303290] |
| phosphodiesterase 7A/High affinity 3`,5`-cyclic-AMP phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] | ||||||||
| ChEMBL | Inhibition of human recombinant PDE7A1 expressed in baculovirus-infected insect Sf9 cells by modified two-step method | B | 6.14 | pIC50 | 730 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2129-2132 [PMID:19303290] |
| GtoPdb | - | - | 6.14 | pIC50 | 730 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2129-32 [PMID:19303290] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
