linezolid [Ligand Id: 10827] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL126 (Linezolid, Pnu-100766, U-100766, U-100,766, Zyvox)
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  • Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial in Human [ChEMBL: CHEMBL5758] [UniProtKB: P31040]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6]
ChEMBL Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assay B 4.49 pIC50 >32000 nM IC50 J Med Chem (2014) 57: 9078-9095 [PMID:25286019]
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL Inhibition of monoamine oxidase A B 4.26 pKi 55000 nM Ki J Med Chem (2008) 51: 1981-1990 [PMID:18338841]
ChEMBL Inhibition of human recombinant MAOA B 4.28 pKi 53000 nM Ki J Med Chem (2007) 50: 5886-5889 [PMID:17988109]
ChEMBL Inhibition human liver MAOA activity B 4.7 pKi 20000 nM Ki Bioorg Med Chem Lett (2007) 17: 337-340 [PMID:17095223]
ChEMBL Inhibition of MAO-A (unknown origin) by luciferase reporter gene assay B 5.1 pKi 7900 nM Ki Bioorg Med Chem (2013) 21: 577-591 [PMID:23273607]
ChEMBL Reversible inhibition of human MAO-A B 4.34 pIC50 46000 nM IC50 Eur J Med Chem (2015) 106: 120-131 [PMID:26536532]
GtoPdb - - 4.34 pIC50 46000 nM IC50 Eur J Med Chem (2015) 106: 120-31 [PMID:26536532]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL Inhibition of MAOB B 4.77 pIC50 17000 nM IC50 Eur J Med Chem (2009) 44: 3584-3590 [PMID:19321235]
ChEMBL Reversible inhibition of human MAO-B B 5.68 pIC50 2100 nM IC50 Eur J Med Chem (2015) 106: 120-131 [PMID:26536532]
GtoPdb - - 5.68 pIC50 2100 nM IC50 Eur J Med Chem (2015) 106: 120-31 [PMID:26536532]
GtoPdb - - 8.32 pIC50 4.77 nM IC50 Eur J Med Chem (2009) 44: 3584-90 [PMID:19321235]
Monoamine oxidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643]
ChEMBL Compound was evaluated for inhibition of Mono aminoxidase B in rat primary hepatocytes B 4.77 pIC50 17000 nM IC50 Bioorg Med Chem Lett (2002) 12: 2121-2123 [PMID:12127518]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5758] [UniProtKB: P31040]
ChEMBL Inhibition of SDH-A (unknown origin) by ELISA B 5.09 pIC50 8190 nM IC50 Bioorg Med Chem Lett (2019) 29: 2686-2689 [PMID:31383589]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]