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ChEMBL ligand: CHEMBL126 (Linezolid, Pnu-100766, U-100,766, U-100766, Zyvox) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Calmodulin-like protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5169127] [UniProtKB: P27482] | ||||||||
ChEMBL | Inhibition of CALML3 (unknown origin) assessed as apparent protein translation inhibition constant incubated for 5 hrs by SDS gel electrophoresis | B | 5.03 | pIC50 | 9300 | nM | IC50 | J Med Chem (2022) 65: 14144-14179 [PMID:36257060] |
DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6] | ||||||||
ChEMBL | Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assay | B | 4.49 | pIC50 | >32000 | nM | IC50 | J Med Chem (2014) 57: 9078-9095 [PMID:25286019] |
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] | ||||||||
ChEMBL | Inhibition of monoamine oxidase A | B | 4.26 | pKi | 55000 | nM | Ki | J Med Chem (2008) 51: 1981-1990 [PMID:18338841] |
ChEMBL | Inhibition of human recombinant MAOA | B | 4.28 | pKi | 53000 | nM | Ki | J Med Chem (2007) 50: 5886-5889 [PMID:17988109] |
ChEMBL | Inhibition human liver MAOA activity | B | 4.7 | pKi | 20000 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 337-340 [PMID:17095223] |
ChEMBL | Inhibition of MAO-A (unknown origin) by luciferase reporter gene assay | B | 5.1 | pKi | 7900 | nM | Ki | Bioorg Med Chem (2013) 21: 577-591 [PMID:23273607] |
ChEMBL | Reversible inhibition of human MAO-A | B | 4.34 | pIC50 | 46000 | nM | IC50 | Eur J Med Chem (2015) 106: 120-131 [PMID:26536532] |
GtoPdb | - | - | 4.34 | pIC50 | 46000 | nM | IC50 | Eur J Med Chem (2015) 106: 120-31 [PMID:26536532] |
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] | ||||||||
ChEMBL | Inhibition of MAOB | B | 4.77 | pIC50 | 17000 | nM | IC50 | Eur J Med Chem (2009) 44: 3584-3590 [PMID:19321235] |
ChEMBL | Reversible inhibition of human MAO-B | B | 5.68 | pIC50 | 2100 | nM | IC50 | Eur J Med Chem (2015) 106: 120-131 [PMID:26536532] |
GtoPdb | - | - | 5.68 | pIC50 | 2100 | nM | IC50 | Eur J Med Chem (2015) 106: 120-31 [PMID:26536532] |
GtoPdb | - | - | 8.32 | pIC50 | 4.77 | nM | IC50 | Eur J Med Chem (2009) 44: 3584-90 [PMID:19321235] |
Monoamine oxidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643] | ||||||||
ChEMBL | Compound was evaluated for inhibition of Mono aminoxidase B in rat primary hepatocytes | B | 4.77 | pIC50 | 17000 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2121-2123 [PMID:12127518] |
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5758] [UniProtKB: P31040] | ||||||||
ChEMBL | Inhibition of SDH-A (unknown origin) by ELISA | B | 5.09 | pIC50 | 8190 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2686-2689 [PMID:31383589] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]