CS2164

Ligand id: 10475

Name: CS2164

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 86.47
Molecular weight 435.16
XLogP 4.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-(2-aminophenyl)-6-(7-methoxyquinolin-4-yl)oxynaphthalene-1-carboxamide
Synonyms
chiauranib (pseudo INN) | CS-2164 | example 32 [US20100298358A1]
Comments
CS2164 is a multi-target kinase inhibitor that exerts anti-angiogenic, anti-mitotic and anti-inflammatory effects that mediate anti-tumour activity [3]. Via inhibition of Aurora B CS2164 mediates inhibition of histone 3 (H3) phosphorylation which is associated with cell cycle arrest. CS2164 was developed by Chipscreen Biosciences and is claimed in their patent US20100298358A1 [2].
Database Links
GtoPdb PubChem SID 385612234
PubChem CID 49779393
Search Google for chemical match using the InChIKey BRKWREZNORONDU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BRKWREZNORONDU
Search UniChem for chemical match using the InChIKey BRKWREZNORONDU-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone BRKWREZNORONDU