CS2164   

GtoPdb Ligand ID: 10475

Synonyms: chiauranib (pseudo INN) | CS-2164 | example 32 [US20100298358A1]
Compound class: Synthetic organic
Comment: CS2164 is a multi-target kinase inhibitor that exerts anti-angiogenic, anti-mitotic and anti-inflammatory effects that mediate anti-tumour activity [3]. Via inhibition of Aurora B CS2164 mediates inhibition of histone 3 (H3) phosphorylation which is associated with cell cycle arrest. CS2164 was developed by Chipscreen Biosciences and is claimed in their patent US20100298358A1 [2].
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 86.47
Molecular weight 435.16
XLogP 4.94
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES COc1ccc2c(c1)nccc2Oc1ccc2c(c1)cccc2C(=O)Nc1ccccc1N
Isomeric SMILES COc1ccc2c(c1)nccc2Oc1ccc2c(c1)cccc2C(=O)Nc1ccccc1N
InChI InChI=1S/C27H21N3O3/c1-32-18-9-12-22-25(16-18)29-14-13-26(22)33-19-10-11-20-17(15-19)5-4-6-21(20)27(31)30-24-8-3-2-7-23(24)28/h2-16H,28H2,1H3,(H,30,31)
InChI Key BRKWREZNORONDU-UHFFFAOYSA-N
References
1. Deng M, Shi Y, Chen K, Zhao H, Wang Y, Xie S, Zhao J, Luo Y, Fang Z, Fan Y et al.. (2018)
CS2164 exerts an antitumor effect against human Non-Hodgkin's lymphomas in vitro and in vivo.
Exp. Cell Res., 369 (2): 356-362. [PMID:29864401]
2. Lu X-P, Li Z, Yu J, Ning Z. (2010)
Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors.
Patent number: US20100298358A1. Assignee: SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.. Priority date: 22/05/2009. Publication date: 25/11/2010.
3. Zhou Y, Shan S, Li ZB, Xin LJ, Pan DS, Yang QJ, Liu YP, Yue XP, Liu XR, Gao JZ et al.. (2017)
CS2164, a novel multi-target inhibitor against tumor angiogenesis, mitosis and chronic inflammation with anti-tumor potency.
Cancer Sci., 108 (3): 469-477. [PMID:28004478]