CS2164

Ligand id: 10475

Name: CS2164

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 86.47
Molecular weight 435.16
XLogP 4.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
The antiproliferative, pro-apoptotic and cytotoxic effects of CS2164 against human non-Hodgkin's lymphoma in vitro and in vivo were reported by Deng et al. in 2018 [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
aurora kinase B Hs Inhibitor Inhibition 8.1 pIC50 - 3
pIC50 8.1 (IC50 9x10-9 M) [3]
Description: Inhibition in a biochemical assay.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
platelet derived growth factor receptor alpha Hs Inhibitor Inhibition 9.0 pIC50 - 3
pIC50 9.0 (IC50 1x10-9 M) [3]
Description: Inhibition in a biochemical assay.
KIT proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 8.4 pIC50 - 3
pIC50 8.4 (IC50 4x10-9 M) [3]
Description: Inhibition in a biochemical assay.
colony stimulating factor 1 receptor Hs Inhibitor Inhibition 8.1 pIC50 - 3
pIC50 8.1 (IC50 7x10-9 M) [3]
kinase insert domain receptor Hs Inhibitor Inhibition 8.1 pIC50 - 3
pIC50 8.1 (IC50 7x10-9 M) [3]
Description: Inhibition in a biochemical assay.
fms related tyrosine kinase 1 Hs Inhibitor Inhibition 8.1 pIC50 - 3
pIC50 8.1 (IC50 8x10-9 M) [3]
Description: Inhibition in a biochemical assay.
fms related tyrosine kinase 4 Hs Inhibitor Inhibition 8.1 pIC50 - 3
pIC50 8.1 (IC50 9x10-9 M) [3]
Description: Inhibition in a biochemical assay.
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 7.0 pIC50 - 3
pIC50 7.0 (IC50 9.3x10-8 M) [3]
Description: Inhibition in a biochemical assay.