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ChEMBL ligand: CHEMBL32571 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] | ||||||||
ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] | ||||||||
ChEMBL | Inhibition of rat serum Butyrylcholine esterase using butyrylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
Dipeptidyl peptidase IV in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3813] [UniProtKB: P22411] | ||||||||
ChEMBL | Inhibition of porcine DPP4 after 30 mins by luminescence assay | B | 5.6 | pIC50 | 2500 | nM | IC50 | Eur J Med Chem (2018) 151: 145-157 [PMID:29609120] |
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rat Artery myocytes | F | 4 | pIC50 | 100000 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6] | ||||||||
GtoPdb | - | - | 5.2 | pIC50 | - | - | - |
Br J Pharmacol (2013) 168: 1835-50 [PMID:23190005]; Mol Pharmacol (2013) 84: 736-50 [PMID:24006495] |
TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534] | ||||||||
GtoPdb | - | - | 4.48 | pEC50 | 32900 | nM | EC50 | J Agric Food Chem (2013) 61: 10454-66 [PMID:24117141] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]