naringenin [Ligand Id: 10298] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL32571
  • acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
There should be some charts here, you may need to enable JavaScript!
  • TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6]
There should be some charts here, you may need to enable JavaScript!
  • TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136]
ChEMBL Inhibition of rat cortex AChE using acetylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method B 4.3 pIC50 >50000 nM IC50 Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231]
Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1]
ChEMBL Inhibition of rat serum Butyrylcholine esterase using butyrylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method B 4.3 pIC50 >50000 nM IC50 Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231]
Dipeptidyl peptidase IV in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3813] [UniProtKB: P22411]
ChEMBL Inhibition of porcine DPP4 after 30 mins by luminescence assay B 5.6 pIC50 2500 nM IC50 Eur J Med Chem (2018) 151: 145-157 [PMID:29609120]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
ChEMBL Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rat Artery myocytes F 4 pIC50 100000 nM IC50 IC50 data for the L-type calcium channel extracted from a set of literature articles
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6]
GtoPdb - - 5.2 pIC50 - - - Br J Pharmacol (2013) 168: 1835-50 [PMID:23190005];
Mol Pharmacol (2013) 84: 736-50 [PMID:24006495]
TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534]
GtoPdb - - 4.48 pEC50 32900 nM EC50 J Agric Food Chem (2013) 61: 10454-66 [PMID:24117141]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]