tifluadom [Ligand Id: 1667] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL169703 (KC-5103, Tifluadom) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Binding affinity against Cholecystokinin type A receptor using [125I](BH)-CCK-8 as radioligand in rat pancreas. | B | 7.33 | pKi | 47 | nM | Ki | J Med Chem (1996) 39: 860-872 [PMID:8632410] |
| ChEMBL | Inhibition of binding of [125I]CCK-8 to Cholecystokinin type A receptor in rat pancreas | B | 7.33 | pIC50 | 47 | nM | IC50 | J Med Chem (1990) 33: 450-455 [PMID:2153212] |
| CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| ChEMBL | Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex. | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (1996) 39: 860-872 [PMID:8632410] |
| ChEMBL | Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1990) 33: 450-455 [PMID:2153212] |
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Binding affinity against Opioid receptor delta 1 using [3H]DADLE as radioligand in guinea pig brain | B | 6.82 | pKi | 153 | nM | Ki | J Med Chem (1996) 39: 860-872 [PMID:8632410] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| GtoPdb | - | - | 8.8 | pKi | - | - | - | J Pharmacol Exp Ther (1997) 282: 676-84 [PMID:9262330] |
| ChEMBL | Binding affinity to kappa opioid receptor | B | 9.77 | pKi | 0.17 | nM | Ki | Bioorg Med Chem (2010) 18: 4446-4452 [PMID:20478711] |
| Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144] | ||||||||
| ChEMBL | Binding affinity against Opioid receptor kappa 1 of guinea pig using [3H]U-65693 as radioligand | B | 9.11 | pKi | 0.78 | nM | Ki | J Med Chem (1996) 39: 860-872 [PMID:8632410] |
| Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266] | ||||||||
| ChEMBL | Binding affinity against Opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain | B | 8.71 | pKi | 1.93 | nM | Ki | J Med Chem (1996) 39: 860-872 [PMID:8632410] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
