frovatriptan [Ligand Id: 7191] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1279 (Frova, Migard, Mylatrip, Frovatriptan)
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor B 7.21 pKi 62 nM Ki J. Med. Chem. (1999) 42: 526-531 [PMID:9986723]
GtoPdb - - 7.22 pKi 60 nM Ki J Med Chem (1999) 42: 526-31 [PMID:9986723]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor B 7.99 pKi 10.3 nM Ki J. Med. Chem. (1999) 42: 526-531 [PMID:9986723]
GtoPdb - - 7.99 pKi 10.3 nM Ki J Med Chem (1999) 42: 526-31 [PMID:9986723]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor B 8.36 pKi 4.4 nM Ki J. Med. Chem. (1999) 42: 526-531 [PMID:9986723]
GtoPdb - - 8.36 pKi 4.4 nM Ki J Med Chem (1999) 42: 526-31 [PMID:9986723]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]