Synonyms: LY 2584702 | LY-2584702
Compound class:
Synthetic organic
Comment: LY2584702 is reported as an ATP competitive, selective inhibitor of the p70 ribosomal protein S6 kinase (p70S6K) [3]. p70S6K is a downstream component of the PI3K/Akt/mTOR signalling pathway which regulates cell proliferation and survival. LY2584702 was originally developed as a potential oncology therapeutic, but the programme was terminated due to a lack of clinical efficacy. Subsequent study has discovered that LY2584702 produces effects that indicate potential efficacy as a therapy for dyslipidemia [2]. In healthy dyslipidemic volunteers LY2584702 dose‐dependently and significantly reduced pasma low‐density lipoprotein cholesterol and triglycerides, whilst leaving high‐density lipoprotein cholesterol levels unchanged. However, metabolism of LY2584702 generates 4-aminopyrazolo[3,4-d]pyrimidine (4-APP; PubChem CID 75420), a compound which may contribute towards the adverse hepatotoxicity associated with LY2584702 exposure. Further determination of the anti-dyslipidemia potential of p70S6K inhibitors could be advanced by the development of non-4-APP forming compounds.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine |
Synonyms ![]() |
LY 2584702 | LY-2584702 |
Database Links ![]() |
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CAS Registry No. | 1082949-67-4 |
GtoPdb PubChem SID | 249565928 |
PubChem CID | 25118925 |
Search Google for chemical match using the InChIKey | FYXRSVDHGLUMHB-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | FYXRSVDHGLUMHB |
UniChem Compound Search for chemical match using the InChIKey | FYXRSVDHGLUMHB-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | FYXRSVDHGLUMHB-UHFFFAOYSA-N |