L-ascorbic acid [Ligand Id: 4781] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL196 (FEMA NO. 2109, Ascor, L-ascorbic acid, Redoxon c, Ascorbic acid component of plenvu, L-ascorbate, Redoxon, Acido ascorbico, Vital life, Bassett's, Ascorbic acid component of vitaped, Ascorbic acid (vit c), INS NO.300, Ascur, Ascorbicum acidum, Redoxon slow release, E-300, Haliborange, Ascoltin, Vitamin c (as ascorbic acid), Top c, Ascorbicap, Ascorbic acid, INS-300, Ascorbate, Ascorbic acid, l-, 3-keto-l-gulofuranolactone, NSC-33832, Redoxon chew-c, E300, Acide ascorbique, Ascorbic acid component of moviprep, Acidum ascorbicum, NSC-218455) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α2B-adrenoceptor/Alpha-2B adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
| ChEMBL | Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay | F | 9.3 | pEC50 | 0.5 | nM | EC50 | Bioorg Med Chem (2009) 17: 2497-2500 [PMID:19243956] |
| amylase alpha 2A/Pancreatic alpha-amylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2699] [GtoPdb: 2596] [UniProtKB: P00689] | ||||||||
| ChEMBL | Inhibitory constant against Alpha-amylase | B | 4.36 | pKi | 43400 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1575-1576 [PMID:10915054] |
| ChEMBL | The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay | B | 4.58 | pIC50 | 26500 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1575-1576 [PMID:10915054] |
| tyrosinase/Tyrosinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1973] [GtoPdb: 2643] [UniProtKB: P14679] | ||||||||
| ChEMBL | Inhibition of tyrosinase (unknown origin) | B | 4.49 | pIC50 | 32500 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 1476-1478 [PMID:25726329] |
| Urease in Canavalia ensiformis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4161] [UniProtKB: P07374] | ||||||||
| ChEMBL | Inhibition of jack bean urease | B | 5.07 | pIC50 | 8590 | nM | IC50 | Eur J Med Chem (2022) 234: 114273-114273 [PMID:35305460] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
