aloisine [Ligand Id: 5923] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL306498 (Aloisine) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Inhibitory activity against cyclin-dependent kinase 1-cyclin B in starfish | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] | ||||||||
| GtoPdb | Measuring inhibition of CDK2 in association with cyclin E | - | 9.28 | pKi | 0.53 | nM | Ki | J Med Chem (2012) 55: 1926-39 [PMID:22289061] |
| ChEMBL | Inhibition of human recombinant CDK2/CycE using HHASPRK as substrate by ESI-MS analysis | B | 9.28 | pKi | 0.52 | nM | Ki | J Med Chem (2012) 55: 1926-1939 [PMID:22289061] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| ChEMBL | Inhibitory activity against recombinant mammalian cyclin-dependent kinase 5 (p35 NCK5a) expressed in Escherichia coli | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of glycogen synthase kinase-3 beta, purified from porcine brain or expressed in and purified from insect Sf9 cells | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
| protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] | ||||||||
| GtoPdb | - | - | 6.03 | pKi | 933 | nM | Ki | J Med Chem (2012) 55: 1926-39 [PMID:22289061] |
| ChEMBL | Inhibition of human recombinant PYK2 by ESI-MS analysis | B | 6.03 | pKi | 933.25 | nM | Ki | J Med Chem (2012) 55: 1926-1939 [PMID:22289061] |
| zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
| ChEMBL | Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysis | B | 5.58 | pKi | 2630.27 | nM | Ki | J Med Chem (2012) 55: 1926-1939 [PMID:22289061] |
| GtoPdb | - | - | 5.58 | pKi | 2630 | nM | Ki | J Med Chem (2012) 55: 1926-39 [PMID:22289061] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
