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ChEMBL ligand: CHEMBL1433 (Anhydrous doxycycline, Doxycycline (anhydrous)) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
ChEMBL | Inhibition of human MMP13 | B | 4.4 | pIC50 | 40000 | nM | IC50 | Bioorg Med Chem (2007) 15: 2368-2374 [PMID:17267227] |
ChEMBL | Inhibition of MMP-13 (unknown origin) | B | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
ChEMBL | Inhibition of MMP-2 (unknown origin) | B | 4.25 | pIC50 | 56000 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
ChEMBL | Inhibition of human MMP2 | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem (2007) 15: 2368-2374 [PMID:17267227] |
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
ChEMBL | Inhibition of MMP-3 (unknown origin) | B | 4.49 | pIC50 | 32000 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
ChEMBL | Inhibition of human MMP3 | B | 4.6 | pIC50 | 25000 | nM | IC50 | Bioorg Med Chem (2007) 15: 2368-2374 [PMID:17267227] |
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
GtoPdb | - | - | 4.14 | pKd | 73000 | nM | Kd | Mol Pharmacol (2005) 67: 1128-36 [PMID:15665254] |
ChEMBL | Inhibition of MMP-7 (unknown origin) | B | 4.55 | pIC50 | 28000 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
ChEMBL | Inhibition of human MMP8 | B | 4.51 | pIC50 | 31000 | nM | IC50 | Bioorg Med Chem (2007) 15: 2368-2374 [PMID:17267227] |
ChEMBL | Inhibition of MMP-8 (unknown origin) | B | 4.59 | pIC50 | 26000 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
GtoPdb | - | - | 4.6 | pIC50 | 26000 | nM | IC50 | Chest (1995) 107: 1641-7 [PMID:7781360] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.83 | pIC50 | 14900 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.83 | pIC50 | 14900 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.86 | pIC50 | 13700 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.87 | pIC50 | 13400 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.88 | pIC50 | 13300 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.88 | pIC50 | 13300 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.88 | pIC50 | 13300 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.88 | pIC50 | 13200 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.89 | pIC50 | 12900 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.89 | pIC50 | 12900 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 106/1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.89 | pIC50 | 12800 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.92 | pIC50 | 12100 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.94 | pIC50 | 11600 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.94 | pIC50 | 11500 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.96 | pIC50 | 11060 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.96 | pIC50 | 10900 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.97 | pIC50 | 10800 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.97 | pIC50 | 10700 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.97 | pIC50 | 10600 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.97 | pIC50 | 10600 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.99 | pIC50 | 10200 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.01 | pIC50 | 9700 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 5.01 | pIC50 | 9700 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 31 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.01 | pIC50 | 9700 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.04 | pIC50 | 9200 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.04 | pIC50 | 9100 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 5.04 | pIC50 | 9100 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antiplasmodial activity against chloroquinone-resistant Plasmodium falciparum W2 | F | 5.05 | pIC50 | 9000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 396-401 [PMID:17981462] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.06 | pIC50 | 8700 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 5.08 | pIC50 | 8400 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity as reduced parasitaemia after 48 hrs against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in type A+ human erythrocytes by flow cytometry | F | 5.19 | pIC50 | 6500 | nM | IC50 | Bioorg Med Chem (2009) 17: 4313-4322 [PMID:19482476] |
ChEMBL | Antimalarial activity against chloroquine, pyrimethamine, proguanil-resistant Plasmodium falciparum infected in human erythrocytes after 48 hrs by flow cytometry | F | 5.19 | pIC50 | 6500 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5962-5964 [PMID:19748781] |
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocyte after 48 hrs by flow cytometry | F | 5.19 | pIC50 | 6500 | nM | IC50 | Eur J Med Chem (2010) 45: 616-622 [PMID:19926173] |
ChEMBL | Antiplasmodial activity against chloroquine/pyrimethamine/proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green 1 dye based fluorescence spectrophotometric method | F | 5.22 | pIC50 | 6000 | nM | IC50 | Eur J Med Chem (2017) 125: 68-86 [PMID:27654395] |
ChEMBL | Antiplasmodial activity against chloroquine/purimethamine/proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as reduction in parasitaemia measured after 72 hrs by SYBR Green I fluorescence-based assay | F | 5.22 | pIC50 | 6000 | nM | IC50 | Eur J Med Chem (2016) 119: 34-44 [PMID:27155463] |
ChEMBL | Antiplasmodial activity against chloroquine-, pyrimethamine- and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green I fluorescence-based method | F | 5.22 | pIC50 | 6000 | nM | IC50 | Eur J Med Chem (2014) 83: 26-35 [PMID:24946216] |
ChEMBL | Antiplasmodial activity after 48 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | F | 5.27 | pIC50 | 5420 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275] |
ChEMBL | Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry | F | 5.27 | pIC50 | 5320 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
ChEMBL | Antimalarial activity against multi-resistant Plasmodium falciparum infected in human erythrocytes assessed as inhibition of [G-3H]hypoxanthine uptake incubated for 42 hrs by liquid scintillation counting method | F | 5.29 | pIC50 | 5100 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 ring stage after 72 hrs by SYBP Green fluorescence-based assay | F | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2012) 55: 315-324 [PMID:22889559] |
ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine, and proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes after 72 hrs by SYBR Green-I fluorescence-based method | F | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6003-6006 [PMID:21852132] |
ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in Parasitemia incubated for 72 hrs by SYBR Green I fluorescence-based method | F | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2014) 87: 440-453 [PMID:25282267] |
ChEMBL | Antiplasmodial activity against multi-drug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay | F | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2015) 95: 16-28 [PMID:25791675] |
ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay | F | 5.32 | pIC50 | 4800 | nM | IC50 | Eur J Med Chem (2011) 46: 4184-4191 [PMID:21741131] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10354 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.34 | pIC50 | 4600 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
ChEMBL | Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay | F | 5.37 | pIC50 | 4276.01 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 4040-4042 [PMID:19596882] |
ChEMBL | Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry | F | 5.48 | pIC50 | 3300 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay | F | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antiplasmodial activity after 72 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | F | 5.83 | pIC50 | 1490 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275] |
ChEMBL | Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake | F | 5.84 | pIC50 | 1444.1 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay | F | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
ChEMBL | Antiplasmodial activity after 96 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | F | 6.14 | pIC50 | 720 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275] |
ChEMBL | Antimalarial activity against Plasmodium falciparum clinical isolate after 6 days by HRP2 enzyme-linked immunosorbent assay | F | 6.14 | pIC50 | 720 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 540-542 [PMID:19841147] |
ChEMBL | Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake | F | 6.22 | pIC50 | 603.1 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
ChEMBL | Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free | F | 6.34 | pIC50 | 453 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
ChEMBL | Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake | F | 6.36 | pIC50 | 432.2 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
ChEMBL | Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake | F | 6.52 | pIC50 | 302.5 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
ChEMBL | Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free | F | 6.68 | pIC50 | 211 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
ChEMBL | Antiplasmodial activity after 120 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | F | 6.92 | pIC50 | 120 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275] |
ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green I fluorescence based assay | F | 5.22 | pEC50 | 6000 | nM | EC50 | Eur J Med Chem (2021) 224: 113722-113722 [PMID:34364164] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]