denopamine [Ligand Id: 534] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL493682 (Denopamine)
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
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  • β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy B 4.33 pIC50 46900 nM IC50 J. Med. Chem. (2008) 51: 5932-5942 [PMID:18788725]
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 5.8 pKi 1584 nM Ki Mol. Pharmacol. (1999) 56: 875-85 [PMID:10531390];
J. Pharmacol. Exp. Ther. (1993) 267: 785-90 [PMID:7902433]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]