Synonyms: compound 3 [PMID: 30405246] | diABZI | diABZI STING agonist-1
Compound class:
Synthetic organic
Comment: This compound is an optimised derivative of STING agonist 2 that has improved solubility and improved potency in primary cells [4]. Like agonist 2 it is one of the chemical structures claimed in GlaxoSmithKline's patent WO2017175147A1 [1]. it behaves as a cyclic dinucleotide mimic to activate the STING pathway.
SARS-CoV-2: Preclinical experimental evidence (in mice) suggests that this STING agonist may be effective in controlling infection by a range of SARS-CoV-2 variants, including B.1.351 (the beta variant [3]) [2]. The mechanistic hypothesis is that directly activating STING transiently stimulates interferon (IFN) signalling and circumvents the virus' ability to block IFN activation in infected respiratory epithelial cells, and re-establishes the innate immune response to infection. |
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Classification ![]() |
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Compound class | Synthetic organic |
Synonyms ![]() |
compound 3 [PMID: 30405246] | diABZI | diABZI STING agonist-1 |
Database Links ![]() |
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GtoPdb PubChem SID | 381118838 |
PubChem CID | 131986624 |
Search Google for chemical match using the InChIKey | JGLMVXWAHNTPRF-CMDGGOBGSA-N |
Search Google for chemicals with the same backbone | JGLMVXWAHNTPRF |
UniChem Compound Search for chemical match using the InChIKey | JGLMVXWAHNTPRF-CMDGGOBGSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JGLMVXWAHNTPRF-CMDGGOBGSA-N |