Synonyms: HMR3480 | VX-765
Compound class:
Synthetic organic
Comment: Belnacasan is a prodrug of VRT-043198, a caspase-1 inhibitor that was developed by Vertex. Pharmacological inhibition of caspase-1 is being investigated as a mechanism to reduce pro-inflammatory cytokine (predominantly IL-1β) production as a novel treatment of inflammatory diseases [1]. Inhibition of caspase-1 is a small molecule strategy developed as an alternative to the use of anti-IL-1β neutralising antibodies, such as canakinumab, or the dimeric fusion protein rilonacept that acts as a IL-1 trap.
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Classification ![]() |
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Compound class | Synthetic organic |
Is prodrug? | Yes |
Active form | VRT-043198 |
IUPAC Name ![]() |
(2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide |
Synonyms ![]() |
HMR3480 | VX-765 |
Database Links ![]() |
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GtoPdb PubChem SID | 315661120 |
PubChem CID | 11398092 |
Search Google for chemical match using the InChIKey | SJDDOCKBXFJEJB-MOKWFATOSA-N |
Search Google for chemicals with the same backbone | SJDDOCKBXFJEJB |
UniChem Compound Search for chemical match using the InChIKey | SJDDOCKBXFJEJB-MOKWFATOSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | SJDDOCKBXFJEJB-MOKWFATOSA-N |
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