didanosine [Ligand Id: 4833] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1460 (Didanosine system suitability mixture, Didanosine, Ddi, Videx, Videx ec, Dideoxyinosine (ddi), BMY-40900, NSC-612049)
  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Inhibitory concentration against SO561945 (HIV 1 mutant RT) viral infection of MT-4 cells F 5.15 pIC50 7150 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 3173-3176 [PMID:15149669]
ChEMBL Concentration required to protect the cell against HIV-1 strain IIIB viral cytopathogenicity by 50% in MT-4 cells F 5.27 pIC50 5370 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 3173-3176 [PMID:15149669]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]