pamoic acid [Ligand Id: 2920] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL177880 (Pamoic Acid)
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [UniProtKB: P06746]
ChEMBL Inhibition of DNA polymerase beta (unknown origin) B 5.05 pIC50 9000 nM IC50 J. Med. Chem. (2013) 56: 5182-5197 [PMID:23713606]
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis B 7.94 pKi 11.5 nM Ki J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay B 5.92 pEC50 1200 nM EC50 J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay B 6.3 pEC50 500 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
GtoPdb - - 7.29 pEC50 - - - Biochem J (2010) 432: 451-9 [PMID:20919992]
ChEMBL Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay B 7.3 pEC50 50 nM EC50 J. Med. Chem. (2013) 56: 5182-5197 [PMID:23713606]
ChEMBL Agonist activity at human GPR35 by DMR assay B 8.68 pEC50 2.1 nM EC50 J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay B 8.7 pEC50 2 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
GPR35 in Rat [GtoPdb: 102] [UniProtKB: Q33BM1]
GtoPdb - - 5 pEC50 - - - Biochem J (2010) 432: 451-9 [PMID:20919992]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]