ChEMBL ligand: CHEMBL2063869 (Gdc-0152)
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 7/Baculoviral IAP repeat-containing protein 7 in Human [ChEMBL: CHEMBL1075127] [GtoPdb: 2794] [UniProtKB: Q96CA5] There should be some charts here, you may need to enable JavaScript!
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] There should be some charts here, you may need to enable JavaScript!
Max-like protein X in Human [ChEMBL: CHEMBL2062357] [UniProtKB: Q9UH92] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
ChEMBL	Binding affinity to cIAP1-BIR3 domain (unknown origin)	B	7.77	pKd	17	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Displacement of AVPFAK(5-FAM)K (Hid-FAM) from cIAP1 BIR2 domain after 30 mins by fluorescence polarization-based competition assay	B	4.84	pKi	14500	nM	Ki	J Med Chem (2012) 55: 4101-4113 [PMID:22413863]
ChEMBL	Displacement of 5-FAM-conjugated AVP-diPhe-FAM from cIAP1 BIR3 domain after 30 mins by fluorescence polarization-based competition assay	B	7.77	pKi	17	nM	Ki	J Med Chem (2012) 55: 4101-4113 [PMID:22413863]
GtoPdb	BIR3 domain of hcIAP1 (BIRC2)	-	7.77	pKi	17	nM	Ki	J Med Chem (2012) 55: 4101-13 [PMID:22413863]
ChEMBL	Displacement of AVPIAQKSEK-biotin from cIAP1 BIR3 (unknown origin) after 1 hr by DELFIA	B	7.98	pIC50	10.4	nM	IC50	J Med Chem (2018) 61: 6350-6363 [PMID:29940121]
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489]
ChEMBL	Binding affinity to cIAP2-BIR3 domain (unknown origin)	B	7.37	pKd	43	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Displacement of AVPFAK(5-FAM)K (Hid-FAM) from cIAP2 BIR2 domain after 30 mins by fluorescence polarization-based competition assay	B	5.02	pKi	9600	nM	Ki	J Med Chem (2012) 55: 4101-4113 [PMID:22413863]
ChEMBL	Displacement of 5-FAM-conjugated AVP-diPhe-FAM from cIAP2 BIR3 domain after 30 mins by fluorescence polarization-based competition assay	B	7.37	pKi	43	nM	Ki	J Med Chem (2012) 55: 4101-4113 [PMID:22413863]
GtoPdb	BIR3 domain of hcIPA2 (BIRC3)	-	7.37	pKi	43	nM	Ki	J Med Chem (2012) 55: 4101-13 [PMID:22413863]
ChEMBL	Displacement of AVPIAQKSEK-biotin from cIAP2 BIR3 (unknown origin) after 1 hr by DELFIA	B	7.89	pIC50	12.9	nM	IC50	J Med Chem (2018) 61: 6350-6363 [PMID:29940121]
baculoviral IAP repeat containing 7/Baculoviral IAP repeat-containing protein 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075127] [GtoPdb: 2794] [UniProtKB: Q96CA5]
ChEMBL	Binding affinity to ML-IAP-BIR domain (unknown origin)	B	7.85	pKd	14	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Binding affinity to ML-IAP BIR domain after 30 mins by fluorescence polarization-based competition assay	B	7.3	pKi	<50	nM	Ki	J Med Chem (2012) 55: 4101-4113 [PMID:22413863]
GtoPdb	BIR domain of hML-IAP (BIRC7)	-	7.85	pKi	14	nM	Ki	J Med Chem (2012) 55: 4101-13 [PMID:22413863]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL	Binding affinity to XIAP-BIR2 domain (unknown origin) by fluorescence polarization-based competition assay	B	6.95	pKd	112	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Binding affinity to N-terminal His-tagged human recombinant XIAP BIR3 (253 to 347 residues) expressed in Escherichia coli BL21(DE3) Gold by isothermal titration calorimetric analysis	B	7.06	pKd	88	nM	Kd	J Med Chem (2018) 61: 6350-6363 [PMID:29940121]
ChEMBL	Binding affinity to XIAP-BIR3 domain (241 to 356 residues) (unknown origin) by fluorescence polarization-based competition assay	B	7.55	pKd	28	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay	B	4.53	pKi	29800	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4253-4257 [PMID:23743278]
ChEMBL	Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay	B	6.59	pKi	260	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4253-4257 [PMID:23743278]
ChEMBL	Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR2 domain after 30 mins by fluorescence polarization-based competition assay	B	6.95	pKi	112	nM	Ki	J Med Chem (2012) 55: 4101-4113 [PMID:22413863]
GtoPdb	BIR3 domain of hXIAP	-	7.55	pKi	28	nM	Ki	J Med Chem (2012) 55: 4101-13 [PMID:22413863]
ChEMBL	Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay	B	7.55	pKi	28	nM	Ki	J Med Chem (2012) 55: 4101-4113 [PMID:22413863]
ChEMBL	Displacement of AVPIAQKSEK-biotin from N-terminal His-tagged human recombinant XIAP BIR3 (253 to 347 residues) expressed in Escherichia coli BL21(DE3) Gold after 1 hr by DELFIA	B	7.28	pIC50	52.7	nM	IC50	J Med Chem (2018) 61: 6350-6363 [PMID:29940121]
ChEMBL	Displacement of biotinylated AVPF from N-terminal His tagged recombinant human XIAP-BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 8 hrs by DELFIA	B	7.68	pIC50	21	nM	IC50	J Med Chem (2019) 62: 5616-5627 [PMID:31095386]
ChEMBL	Displacement of biotinylated AVPF from N-terminal His tagged recombinant human XIAP-BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 2 hrs by DELFIA	B	7.68	pIC50	21	nM	IC50	J Med Chem (2019) 62: 5616-5627 [PMID:31095386]
Max-like protein X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2062357] [UniProtKB: Q9UH92]
ChEMBL	Displacement of 5-FAM-conjugated AVP-diPhe-FAM from MLXBIR3SG after 30 mins by fluorescence polarization-based competition assay	B	7.85	pKi	14	nM	Ki	J Med Chem (2012) 55: 4101-4113 [PMID:22413863]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]