ChEMBL ligand: CHEMBL57818
peptidyl arginine deiminase 1/Protein-arginine deiminase type-1 in Human [ChEMBL: CHEMBL1909486] [GtoPdb: 2894] [UniProtKB: Q9ULC6] There should be some charts here, you may need to enable JavaScript!
Protein-arginine deiminase type-2 in Human [ChEMBL: CHEMBL1909487] [UniProtKB: Q9Y2J8] There should be some charts here, you may need to enable JavaScript!
peptidyl arginine deiminase 3/Protein-arginine deiminase type-3 in Human [ChEMBL: CHEMBL1909488] [GtoPdb: 2878] [UniProtKB: Q9ULW8] There should be some charts here, you may need to enable JavaScript!
peptidyl arginine deiminase 4/Protein-arginine deiminase type-4 in Human [ChEMBL: CHEMBL6111] [GtoPdb: 2877] [UniProtKB: Q9UM07] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
peptidyl arginine deiminase 1/Protein-arginine deiminase type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909486] [GtoPdb: 2894] [UniProtKB: Q9ULC6]
ChEMBL	Inhibition of recombinant wild-type PAD1 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay	B	6.02	pIC50	950	nM	IC50	Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480]
Protein-arginine deiminase type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909487] [UniProtKB: Q9Y2J8]
ChEMBL	Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 10 mins followed by substrate addition measured after 15 mins by COLDER assay	B	5.09	pKi	8080	nM	Ki	Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480]
ChEMBL	Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay	B	6.49	pIC50	320	nM	IC50	Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480]
peptidyl arginine deiminase 3/Protein-arginine deiminase type-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909488] [GtoPdb: 2878] [UniProtKB: Q9ULW8]
ChEMBL	Inhibition of recombinant wild-type PAD3 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480]
peptidyl arginine deiminase 4/Protein-arginine deiminase type-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6111] [GtoPdb: 2877] [UniProtKB: Q9UM07]
ChEMBL	Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 10 mins followed by substrate addition measured after 15 mins by COLDER assay	B	4.7	pKi	20100	nM	Ki	Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480]
ChEMBL	Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay	B	6.19	pIC50	640	nM	IC50	Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]