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peptidyl arginine deiminase 3

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Target not currently curated in GtoImmuPdb

Target id: 2878

Nomenclature: peptidyl arginine deiminase 3

Family: 3.5.3.15 Peptidyl arginine deiminases (PADI)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 664 1p36.13 PADI3 peptidyl arginine deiminase 3 3
Mouse - 664 4 72.5 cM Padi3 peptidyl arginine deiminase, type III
Rat - 664 5q36 Padi3 peptidyl arginine deiminase 3
Previous and Unofficial Names Click here for help
PDI3 | peptidyl arginine deiminase, type III | peptidyl arginine deiminase
Database Links Click here for help
Alphafold Q9ULW8 (Hs), Q9Z184 (Mm), P70708 (Rn)
BRENDA 3.5.3.15
CATH/Gene3D 2.60.40.1700
ChEMBL Target CHEMBL1909488 (Hs)
Ensembl Gene ENSG00000142619 (Hs), ENSMUSG00000025328 (Mm), ENSRNOG00000006950 (Rn)
Entrez Gene 51702 (Hs), 18601 (Mm), 29520 (Rn)
Human Protein Atlas ENSG00000142619 (Hs)
KEGG Enzyme 3.5.3.15
KEGG Gene hsa:51702 (Hs), mmu:18601 (Mm), rno:29520 (Rn)
OMIM 606755 (Hs)
Pharos Q9ULW8 (Hs)
RefSeq Nucleotide NM_016233 (Hs), NM_011060 (Mm), NM_017230 (Rn)
RefSeq Protein NP_057317 (Hs), NP_035190 (Mm), NP_058926 (Rn)
UniProtKB Q9ULW8 (Hs), Q9Z184 (Mm), P70708 (Rn)
Wikipedia PADI3 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.5.3.15 protein L-arginine + H2O <=> protein L-citrulline + NH3

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
streptonigrin Small molecule or natural product N/A Inhibition 6.4 pIC50
⤷ pIC50 6.4 (IC50 4.3x10-7 M)
compound 3 [PMID: 24440480] Small molecule or natural product N/A Irreversible inhibition - - 1
⤷ [1]
Description: Kinact/KI = 1.8x103 M-1 min-1
compound 14b [PMID: 25742366] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Irreversible inhibition - - 2
⤷ [2]
Description: Kinact/KI = 1.56x104 M-1 min-1
Cl-amidine Small molecule or natural product Click here for species-specific activity table Hs Inhibition - - 2
⤷ [2]
Description: Kinact/KI = 2.34x103 M-1 min-1
View species-specific inhibitor tables
Tissue Distribution Click here for help
In human scalp skin the protein is detected in the inner root sheath and outer root sheath of hair follicles, particularly in the supramatrix and keratogenous zone. Protein is almost absent from the cornified hair zone.
Species:  Human
Technique:  Immunohistochemistry.
References:  3
Physiological Functions Click here for help
Acts as a modulator of hair structural proteins, including trichohyalin during hair and hair follicle formation.
Species:  Human
Tissue:  Human scalp skin.
References:  3

References

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1. Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR. (2014) Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem, 22 (4): 1362-9. [PMID:24440480]

2. Jamali H, Khan HA, Stringer JR, Chowdhury S, Ellman JA. (2015) Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc, 137 (10): 3616-21. [PMID:25742366]

3. Kanno T, Kawada A, Yamanouchi J, Yosida-Noro C, Yoshiki A, Shiraiwa M, Kusakabe M, Manabe M, Tezuka T, Takahara H. (2000) Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin. J Invest Dermatol, 115 (5): 813-23. [PMID:11069618]

How to cite this page

3.5.3.15 Peptidyl arginine deiminases (PADI): peptidyl arginine deiminase 3. Last modified on 21/03/2017. Accessed on 13/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2878.