ADX-47273 [Ligand Id: 1420] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL381055 (ADX-47273) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| ChEMBL | Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assay | F | 6.7 | pEC50 | 199.53 | nM | EC50 | J Med Chem (2013) 56: 7243-7259 [PMID:23947773] |
| ChEMBL | Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assay | F | 6.7 | pEC50 | 199 | nM | EC50 | J Med Chem (2013) 56: 7243-7259 [PMID:23947773] |
| GtoPdb | - | - | 6.8 | pEC50 | 157 | nM | EC50 | Neuropharmacology (2013) 64: 224-39 [PMID:22884720] |
| ChEMBL | Positive allosteric modulation of human mGluR5 stably expressed in HEK293 cells assessed as Ca2+ flux by FLIPR assay | F | 6.8 | pEC50 | 157 | nM | EC50 | J Med Chem (2013) 56: 7976-7996 [PMID:24050755] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| GtoPdb | - | - | 5.44 | pKi | 3650 | nM | Ki | Neuropharmacology (2013) 64: 224-39 [PMID:22884720] |
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | Neuropharmacology (2005) 49 (S1): 252- |
| ChEMBL | Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes | F | 6.77 | pEC50 | 170 | nM | EC50 | J Med Chem (2006) 49: 3332-3344 [PMID:16722652] |
| ChEMBL | Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as Ca2+ flux by FLIPR assay | F | 7.26 | pEC50 | 55 | nM | EC50 | J Med Chem (2013) 56: 7976-7996 [PMID:24050755] |
| GtoPdb | - | - | 7.26 | pEC50 | 55 | nM | EC50 | Neuropharmacology (2013) 64: 224-39 [PMID:22884720] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
