- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: 4SC-101 | IMU-838 (vidofludimus calcium) | SC12267
Compound class: Synthetic organic
Comment: Vidofludimus (4SC-101) is a small molecule dihydroorotate dehydrogenase (DHOD) inhibitor that was developed for immunosuppressive potential . It has an improved toxicity profile in comparison to the clinically used disease modifying anti-rheumatic drug (DMARD) leflunomide.
Since its initial development, vidofludimus has been superceded by IMU-838 which is an orally active polymorph of vidofludimus calcium (PubChem CID: 56944639) .
SARS-CoV-2 and COVID-19: The target of vidofludimus, DHODH, plays a role in the metabolism of activated T cells and B cells to regulate the inflammatory response. It has been advanced to clinical trial in patients with severe COVID-19, to as attempt to block the release of pro-inflammatory cytokines and temper hyperinflammation in these patients.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|International Nonproprietary Names|
|4SC-101 | IMU-838 (vidofludimus calcium) | SC12267|
|CAS Registry No.||717824-30-1 (source: WHO INN record)|
|GtoPdb PubChem SID||363894154|
|RCSB PDB Ligand||D5H|
|Search Google for chemical match using the InChIKey||XPRDUGXOWVXZLL-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||XPRDUGXOWVXZLL|
|Search PubMed clinical trials||vidofludimus|
|Search PubMed titles||vidofludimus|
|Search PubMed titles/abstracts||vidofludimus|
|UniChem Compound Search for chemical match using the InChIKey||XPRDUGXOWVXZLL-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||XPRDUGXOWVXZLL-UHFFFAOYSA-N|