ChEMBL ligand: CHEMBL113 (Anhydrous caffeine, Cafcit, Caffeine, Caffeine anhydrous, Caffeine melting point standard, Caffeinum, Coffeine, Coffeinum, Durvitan, FEMA NO. 2224, Guaranine, Methyltheobromine, Nodoz, NSC-5036, Pro-plus, Synalgos, Theine, Vivarin, Yeast-vite, Zanthine)
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] There should be some charts here, you may need to enable JavaScript!
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] Adenosine A1 receptor in Guinea pig [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] Adenosine A2a receptor in Guinea pig [ChEMBL: CHEMBL2605] [UniProtKB: P46616] There should be some charts here, you may need to enable JavaScript!
A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] A2B receptor/Adenosine A2b receptor in Mouse [ChEMBL: CHEMBL2237] [GtoPdb: 20] [UniProtKB: Q60614] A2B receptor/Adenosine A2b receptor in Rat [ChEMBL: CHEMBL2592] [GtoPdb: 20] [UniProtKB: P29276] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!
butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] There should be some charts here, you may need to enable JavaScript!
GABAA receptor π subunit/GABAA receptor δ subunit/GABAA receptor α1 subunit/GABAA receptor β1 subunit/GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor α2 subunit/GABAA receptor β2 subunit/GABAA receptor α4 subunit/GABAA receptor ε subunit/GABAA receptor α6 subunit/GABAA receptor γ1 subunit/GABAA receptor γ3 subunit/GABAA receptor θ subunit/GABA-A receptor; anion channel in Human [ChEMBL: CHEMBL2093872] [GtoPdb: 419, 416, 404, 410, 414, 412, 408, 406, 405, 411, 407, 417, 409, 413, 415, 418] [UniProtKB: O00591, O14764, P14867, P18505, P18507, P28472, P31644, P34903, P47869, P47870, P48169, P78334, Q16445, Q8N1C3, Q99928, Q9UN88] There should be some charts here, you may need to enable JavaScript!
Glycogen phosphorylase, muscle form in Rabbit [ChEMBL: CHEMBL4696] [UniProtKB: P00489] There should be some charts here, you may need to enable JavaScript!
Guanine deaminase in Human [ChEMBL: CHEMBL3129] [UniProtKB: Q9Y2T3] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] There should be some charts here, you may need to enable JavaScript!
TLX/Nuclear receptor subfamily 2 group E member 1 in Human [ChEMBL: CHEMBL1961788] [GtoPdb: 615] [UniProtKB: Q9Y466] There should be some charts here, you may need to enable JavaScript!
Palmitoleoyl-protein carboxylesterase NOTUM in Human [ChEMBL: CHEMBL3714531] [UniProtKB: Q6P988] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Inhibition of Acetylcholinesterase (unknown origin)	B	5.1	pIC50	7943.28	nM	IC50	J Med Chem (2021) 64: 7156-7178 [PMID:34019396]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method	B	5.14	pIC50	7250	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077]
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Dissociation constant against Adenosine A1 receptor	B	4.35	pKd	45000	nM	Kd	J Med Chem (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL	Inhibition of human A1 adenosine receptor	B	4.3	pKi	50118.72	nM	Ki	J Med Chem (2021) 64: 7156-7178 [PMID:34019396]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in HEK293T cells	B	4.31	pKi	49000	nM	Ki	Bioorg Med Chem (2008) 16: 3825-3830 [PMID:18262425]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in HEK293T cells by scintillation counting	B	4.31	pKi	49000	nM	Ki	Bioorg Med Chem (2009) 17: 4280-4284 [PMID:19481943]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in HEK293T cells	B	4.31	pKi	49000	nM	Ki	Bioorg Med Chem (2007) 15: 3235-3240 [PMID:17350268]
ChEMBL	Binding affinity to human adenosine A1 receptor	B	4.35	pKi	44900	nM	Ki	Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167]
ChEMBL	Displacement of [3H]CCPA from recombinant human adenosine A1 receptor expressed in CHO cells	B	4.35	pKi	44900	nM	Ki	Bioorg Med Chem (2019) 27: 1195-1210 [PMID:30808606]
ChEMBL	Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells	B	4.35	pKi	44900	nM	Ki	Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167]
ChEMBL	Displacement of [3H]CCPA from human A1 receptor	B	4.35	pKi	44900	nM	Ki	Bioorg Med Chem (2016) 24: 5462-5480 [PMID:27658798]
ChEMBL	Inhibition of human recombinant adenosine A1 receptor	B	4.35	pKi	44900	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells	B	4.35	pKi	44900	nM	Ki	Eur J Med Chem (2011) 46: 3590-3607 [PMID:21664729]
ChEMBL	Antagonist activity at human adenosine A1 receptor assessed as cAMP level by cell based assay	F	4.36	pKi	44000	nM	Ki	Bioorg Med Chem Lett (2013) 23: 3427-3433 [PMID:23602401]
ChEMBL	Binding affinity to adenosine A1 receptor	B	4.54	pKi	29000	nM	Ki	J Nat Prod (2000) 63: 315-317 [PMID:10757709]
GtoPdb	-	-	4.97	pKi	10700	nM	Ki	Neurosci Lett (1993) 150: 191-4 [PMID:8469419]; J Pharmacol Exp Ther (2004) 308: 358-66 [PMID:14563788]; Drug Dev Res (1999) : 45-53
ChEMBL	Binding affinity to human adenosine A1 receptor by radioligand displacement assay	B	4.97	pKi	10700	nM	Ki	Medchemcomm (2018) 9: 951-962 [PMID:30108984]
ChEMBL	Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes incubated for 90 mins by radioligand competition assay	B	4.97	pKi	10700	nM	Ki	Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
ChEMBL	Antagonist activity at adenosine A1 receptor (unknown origin)	F	4.97	pKi	10700	nM	Ki	Eur J Med Chem (2022) 227: 113907-113907 [PMID:34695776]
ChEMBL	Displacement of [3H]CCPA from recombinant human adenosine A1 receptor expressed in CHO cell membranes after 90 mins by liquid scintillation counting method	B	5	pKi	>10000	nM	Ki	J Med Chem (2018) 61: 4301-4316 [PMID:29681156]
ChEMBL	Inhibition of human A1 adenosine receptor	B	4.97	pIC50	10700	nM	IC50	J Med Chem (2021) 64: 7156-7178 [PMID:34019396]
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL	Affinity to A1 adenosine receptor was measured by the displacement of [3H]PIA in bovine brain cortical membrane	B	4.54	pKi	29000	nM	Ki	J Med Chem (1994) 37: 2970-2975 [PMID:8071944]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane	B	4.23	pKi	59000	nM	Ki	J Med Chem (1989) 32: 1231-1237 [PMID:2724296]
ChEMBL	Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranes	B	4.26	pKi	55000	nM	Ki	J Med Chem (1985) 28: 487-492 [PMID:2984420]
ChEMBL	Binding affinity for Adenosine A1 receptor from rat brain using [3H]-PIA as radioligand	B	4.26	pKi	55000	nM	Ki	J Med Chem (1990) 33: 2818-2821 [PMID:2213834]
ChEMBL	Ability to inhibit binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptor in rat cerebral cortical membranes	B	4.26	pKi	55000	nM	Ki	J Med Chem (1986) 29: 1305-1308 [PMID:3806581]
ChEMBL	Binding affinity to Adenosine A1 receptor in rat brain tissue by radioligand displacement assay	B	4.26	pKi	55000	nM	Ki	Bioorg Med Chem (2015) 23: 6641-6649 [PMID:26392370]
ChEMBL	Displacement of N6-[3H]cyclohexyladenosine from adenosine receptor A1 in rat cerebral cortical membrane	B	4.26	pKi	55000	nM	Ki	Eur J Med Chem (2017) 125: 652-656 [PMID:27721150]
ChEMBL	Displacement of [3H]cyclohexyladenosine from adenosine receptor A1 in rat cerebral cortical membranes	B	4.26	pKi	55000	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5951-5955 [PMID:27836398]
ChEMBL	Inhibition of (R)-N6-([3H]-phenylisopropyl) adenosine binding to adenosine A1 receptor from rat cortical membranes	B	4.36	pKi	44000	nM	Ki	J Med Chem (1992) 35: 2342-2345 [PMID:1613758]
ChEMBL	Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes	B	4.36	pKi	44000	nM	Ki	J Med Chem (1989) 32: 1231-1237 [PMID:2724296]
ChEMBL	Displacement of [3H]DPCPX from adenosine receptor A1 in rat brain membrane	B	4.36	pKi	43900	nM	Ki	Eur J Med Chem (2017) 125: 652-656 [PMID:27721150]
ChEMBL	Ability to inhibit binding of [3H]R-PIA to Adenosine A1 receptor in rat brain cortical membranes	B	4.39	pKi	41000	nM	Ki	J Med Chem (1997) 40: 4396-4405 [PMID:9435909]
ChEMBL	Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]R-(phenylisopropyl)-adenosine	B	4.39	pKi	41000	nM	Ki	J Med Chem (1994) 37: 1526-1534 [PMID:8182711]
ChEMBL	Binding affinity against Adenosine A1 receptor by displacing [3H]CHA radioligand in rat brain cortical membrane	B	4.39	pKi	41000	nM	Ki	J Med Chem (2002) 45: 3440-3450 [PMID:12139454]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex membrane	B	4.39	pKi	41000	nM	Ki	Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex	B	4.39	pKi	41000	nM	Ki	Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167]
ChEMBL	Binding affinity to rat adenosine A1 receptor	B	4.39	pKi	41000	nM	Ki	Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167]
ChEMBL	Displacement of [3H]R-PIA from adenosine receptor A1 in rat brain cerebral cortical membranes	B	4.39	pKi	41000	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5951-5955 [PMID:27836398]
ChEMBL	Displacement of [3H]R-PIA from adenosine receptor A1 in rat brain cortical membrane	B	4.39	pKi	41000	nM	Ki	Eur J Med Chem (2017) 125: 652-656 [PMID:27721150]
ChEMBL	Displacement of [3H]CCPA from rat A1 receptor	B	4.39	pKi	41000	nM	Ki	Bioorg Med Chem (2016) 24: 5462-5480 [PMID:27658798]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranes	B	4.39	pKi	41000	nM	Ki	Bioorg Med Chem (2019) 27: 1195-1210 [PMID:30808606]
ChEMBL	Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assay	B	4.39	pKi	41000	nM	Ki	Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
GtoPdb	-	-	4.39	pKi	41000	nM	Ki	J Med Chem (1994) 37: 1526-34 [PMID:8182711]; Pharmacology (1991) 42: 309-21 [PMID:1658821]
ChEMBL	Displacement of [3H]MSX from rat A1 receptor	B	4.49	pKi	32500	nM	Ki	Bioorg Med Chem (2016) 24: 5462-5480 [PMID:27658798]
ChEMBL	Binding affinity against adenosine A1 receptor using N6-[3H]-cyclohexyladenosinene in rat whole brain membranes	B	4.54	pKi	29100	nM	Ki	J Med Chem (1992) 35: 924-930 [PMID:1548682]
ChEMBL	Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand	B	4.54	pKi	29100	nM	Ki	J Med Chem (1993) 36: 2508-2518 [PMID:8355252]
ChEMBL	Inhibition of N6-[3H]cyclohexyladenosine binding to adenosine A1 receptor from whole brain membranes	B	4.54	pKi	29100	nM	Ki	J Med Chem (1992) 35: 2342-2345 [PMID:1613758]
ChEMBL	Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]PIA as radioligand	B	4.54	pKi	29000	nM	Ki	J Med Chem (1993) 36: 2639-2644 [PMID:8410976]
ChEMBL	Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand	B	4.54	pKi	29000	nM	Ki	J Med Chem (1992) 35: 407-422 [PMID:1738138]
ChEMBL	Displacement of [3H]PIA from adenosine A1 receptors of rat brain membrane	B	4.54	pKi	29000	nM	Ki	J Med Chem (1994) 37: 3373-3382 [PMID:7932565]
ChEMBL	Binding affinity against Adenosine A1 receptor in rat brain membrane, using [3H]N6-cyclohexyladenosine as the radioligand	B	4.54	pKi	29000	nM	Ki	J Med Chem (1989) 32: 2247-2254 [PMID:2795597]
ChEMBL	Ability to inhibit binding of [3H]CHA to adenosine A1 receptor in rat brain cortical membranes.	B	4.59	pKi	26000	nM	Ki	J Med Chem (1997) 40: 4396-4405 [PMID:9435909]
ChEMBL	Displacement of [3H]CHA from adenosine receptor A1 in rat brain cortical membrane	B	4.59	pKi	26000	nM	Ki	Eur J Med Chem (2017) 125: 652-656 [PMID:27721150]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane by liquid scintillation counting	B	4.63	pKi	23500	nM	Ki	J Nat Prod (2002) 65: 1479-1485 [PMID:12398547]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane	B	4.73	pKi	18800	nM	Ki	Bioorg Med Chem (2007) 15: 6956-6974 [PMID:17827019]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane	B	4.73	pKi	18800	nM	Ki	Bioorg Med Chem (2007) 15: 5003-5017 [PMID:17499511]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane	B	4.73	pKi	18800	nM	Ki	Eur J Med Chem (2011) 46: 3590-3607 [PMID:21664729]
ChEMBL	Displacement of [3H]CHA from adenosine A1 receptor in rat brain cortical membrane	B	4.77	pKi	17000	nM	Ki	J Nat Prod (1998) 61: 301-305 [PMID:9514015]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranes after 90 mins by liquid scintillation counting method	B	5	pKi	>10000	nM	Ki	J Med Chem (2018) 61: 4301-4316 [PMID:29681156]
Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745]
ChEMBL	Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand	B	4	pKi	100000	nM	Ki	J Med Chem (1992) 35: 3066-3075 [PMID:1501234]
ChEMBL	Inhibition of [3H]cyclohexyladenosine binding to guinea pig forebrain membranes Adenosine A1 receptor	B	4	pKi	>100000	nM	Ki	J Med Chem (1991) 34: 466-469 [PMID:1992150]
ChEMBL	Binding affinity against Adenosine A1 receptor from guinea pig forebrain membranes by N6-[3H]- cyclohexyladenosine displacement.	B	4	pKi	100000	nM	Ki	J Med Chem (1993) 36: 2508-2518 [PMID:8355252]
ChEMBL	Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranes	B	4	pKi	100000	nM	Ki	J Med Chem (1992) 35: 924-930 [PMID:1548682]
ChEMBL	Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]cyclohexyladenosine as radioligand.	B	4	pKi	100000	nM	Ki	J Med Chem (1992) 35: 2342-2345 [PMID:1613758]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method	B	4.6	pKd	25118.86	nM	Kd	J Med Chem (2011) 54: 4312-4323 [PMID:21661720]
ChEMBL	Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	B	5.26	pKd	5510	nM	Kd	ACS Med Chem Lett (2022) 13: 1172-1181 [PMID:35859869]
ChEMBL	Inhibition of human A2a adenosine receptor	B	4.3	pKi	50118.72	nM	Ki	J Med Chem (2021) 64: 7156-7178 [PMID:34019396]
ChEMBL	Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membrane	B	4.32	pKi	48000	nM	Ki	J Med Chem (1994) 37: 2970-2975 [PMID:8071944]
ChEMBL	Binding affinity to human adenosine A2A receptor by radioligand displacement assay	B	4.63	pKi	23400	nM	Ki	Medchemcomm (2018) 9: 951-962 [PMID:30108984]
ChEMBL	Displacement of [3H]MSX from human A2A receptor	B	4.63	pKi	23400	nM	Ki	Bioorg Med Chem (2016) 24: 5462-5480 [PMID:27658798]
ChEMBL	Antagonist activity at adenosine A2A receptor (unknown origin)	F	4.63	pKi	23400	nM	Ki	Eur J Med Chem (2022) 227: 113907-113907 [PMID:34695776]
ChEMBL	Antagonist activity at human adenosine 2A receptor	B	4.63	pKi	23400	nM	Ki	J Med Chem (2020) 63: 12196-12212 [PMID:32667814]
ChEMBL	Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cells	B	4.63	pKi	23400	nM	Ki	Eur J Med Chem (2011) 46: 3590-3607 [PMID:21664729]
ChEMBL	Antagonist activity at human adenosine A2A receptor assessed as cAMP level by cell based assay	F	4.63	pKi	23400	nM	Ki	Bioorg Med Chem Lett (2013) 23: 3427-3433 [PMID:23602401]
ChEMBL	Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assay	B	4.63	pKi	23400	nM	Ki	Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
ChEMBL	Displacement of [3H]MSX2 from recombinant human adenosine A2a receptor expressed in HEK293 cells	B	4.63	pKi	23400	nM	Ki	Bioorg Med Chem (2019) 27: 1195-1210 [PMID:30808606]
ChEMBL	Displacement of [3H]MSX-2 from human adenosine A2A receptor expressed in CHO cells	B	4.63	pKi	23400	nM	Ki	Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167]
ChEMBL	Binding affinity to human adenosine A2A receptor	B	4.63	pKi	23400	nM	Ki	Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167]
ChEMBL	Inhibition of human recombinant adenosine receptor A2a	F	4.63	pKi	23400	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Displacement of [3H]DPCPX from recombinant human adenosine A2A receptor	B	4.63	pKi	23400	nM	Ki	J Med Chem (2018) 61: 4301-4316 [PMID:29681156]
ChEMBL	Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells	B	4.74	pKi	18100	nM	Ki	Bioorg Med Chem (2007) 15: 3235-3240 [PMID:17350268]
ChEMBL	Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells by scintillation counting	B	4.74	pKi	18100	nM	Ki	Bioorg Med Chem (2009) 17: 4280-4284 [PMID:19481943]
ChEMBL	Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells	B	4.74	pKi	18100	nM	Ki	Bioorg Med Chem (2008) 16: 3825-3830 [PMID:18262425]
ChEMBL	DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA)	B	4.94	pKi	11493	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting analysis	B	5.02	pKi	9560	nM	Ki	Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243]
ChEMBL	Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method	B	5.3	pKi	5011.87	nM	Ki	J Med Chem (2011) 54: 4312-4323 [PMID:21661720]
GtoPdb	-	-	5.6	pKi	-	-	-	Biochem Pharmacol (1999) 57: 65-75 [PMID:9920286]; J Pharmacol Exp Ther (2004) 308: 358-66 [PMID:14563788]; Drug Dev Res (1999) : 45-53
ChEMBL	Competitive binding affinity to human adenosine A2A receptor expressed in HEK293 cells after 60 mins by fluorescence polarization assay in presence of MRS5346	B	5.61	pKi	2480	nM	Ki	Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243]
ChEMBL	DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA)	B	4.69	pIC50	20472	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of human A2a adenosine receptor	B	5.02	pIC50	9600	nM	IC50	J Med Chem (2021) 64: 7156-7178 [PMID:34019396]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Binding affinity to Adenosine A2A receptor in rat brain tissue by radioligand displacement assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2015) 23: 6641-6649 [PMID:26392370]
ChEMBL	Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane	B	4.32	pKi	48000	nM	Ki	J Med Chem (1994) 37: 3373-3382 [PMID:7932565]
ChEMBL	Displacement of [3H]NECA from adenosine receptor A2a in rat striatial membrane	B	4.33	pKi	47200	nM	Ki	Eur J Med Chem (2017) 125: 652-656 [PMID:27721150]
ChEMBL	Displacement of [3H]MSX2 from adenosine receptor A2A in rat brain striatum membranes incubated for 30 mins by radioligand competition assay	B	4.35	pKi	45000	nM	Ki	Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
ChEMBL	Binding affinity to the adenosine A2A receptor by displacement of [3H]CGS-21680 in rat brain striatal membrane	B	4.37	pKi	43000	nM	Ki	J Med Chem (2002) 45: 3440-3450 [PMID:12139454]
ChEMBL	Displacement of [3H]NECA from adenosine receptor A2a in rat brain striatal membrane	B	4.37	pKi	43000	nM	Ki	Eur J Med Chem (2017) 125: 652-656 [PMID:27721150]
ChEMBL	Displacement of [3H]NECA from adenosine receptor A2A in rat striatal membranes	B	4.37	pKi	43000	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5951-5955 [PMID:27836398]
ChEMBL	Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatal membrane	B	4.48	pKi	32800	nM	Ki	Eur J Med Chem (2011) 46: 3590-3607 [PMID:21664729]
ChEMBL	Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatal membrane	B	4.49	pKi	32500	nM	Ki	Bioorg Med Chem (2007) 15: 6956-6974 [PMID:17827019]
ChEMBL	Displacement of [3H]MSX2 from adenosine A2A receptor in rat striatal membrane	B	4.49	pKi	32500	nM	Ki	Bioorg Med Chem (2007) 15: 5003-5017 [PMID:17499511]
ChEMBL	Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatum membrane	B	4.49	pKi	32500	nM	Ki	Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574]
ChEMBL	Displacement of [3H]CCPA from rat adenosine A2a receptor	B	4.49	pKi	32500	nM	Ki	Bioorg Med Chem (2019) 27: 1195-1210 [PMID:30808606]
ChEMBL