compound 3a [PMID: 18606542] [Ligand Id: 9872] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL476099 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] | ||||||||
| ChEMBL | Displacement of [3H]RAMH from human histamine H3 receptor expressed in CHO cells | B | 8.4 | pKi | 4 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4377-4379 [PMID:18606542] |
| GtoPdb | Affinity measured in a saturation binding experiment using human H3 receptor-expressing CHO cells, and [3H]-(R)-α-methylhistamine as tracer. | - | 8.4 | pKi | 4 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4377-9 [PMID:18606542] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
