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ChEMBL ligand: CHEMBL1509398 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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lysophospholipase 1/Acyl-protein thioesterase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681631] [GtoPdb: 3290] [UniProtKB: O75608] | ||||||||
ChEMBL | Inhibition of APT1 (unknown origin) by FluPol-ABPP assay | B | 5 | pKi | >10000 | nM | Ki | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
lysophospholipase 2/Acyl-protein thioesterase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1932891] [GtoPdb: 3291] [UniProtKB: O95372] | ||||||||
ChEMBL | Inhibition of APT2 (unknown origin) by FluPol-ABPP assay | B | 6.64 | pKi | 230 | nM | Ki | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
GtoPdb | - | - | 6.64 | pKi | 230 | nM | Ki | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
GtoPdb | - | - | 6.92 | pKi | 120 | nM | Ki | ACS Med Chem Lett (2017) 8: 215-220 [PMID:28197315] |
ChEMBL | Competitive inhibition of HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) preincubated for 30 mins followed by substrate addition by resorufin dye based acetate hydrolysis assay | B | 6.92 | pKi | 120 | nM | Ki | ACS Med Chem Lett (2017) 8: 215-220 [PMID:28197315] |
ChEMBL | Inhibition of fluorescein-labeled ML349 binding to HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) after 30 mins by fluorescence polarization assay | B | 5.96 | pIC50 | 1100 | nM | IC50 | ACS Med Chem Lett (2017) 8: 215-220 [PMID:28197315] |
Pyridoxal kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075181] [UniProtKB: O00764] | ||||||||
ChEMBL | Inhibition of fluorescein-labeled ML349 binding to HEK293T cells-derived His-tagged PDXK expressed in Escherichia coli BL21(DE3) after 30 mins by fluorescence polarization assay | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2017) 8: 215-220 [PMID:28197315] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]