ChEMBL ligand: CHEMBL1509398
lysophospholipase 1/Acyl-protein thioesterase 1 in Human [ChEMBL: CHEMBL1681631] [GtoPdb: 3290] [UniProtKB: O75608] There should be some charts here, you may need to enable JavaScript!
lysophospholipase 2/Acyl-protein thioesterase 2 in Human [ChEMBL: CHEMBL1932891] [GtoPdb: 3291] [UniProtKB: O95372] There should be some charts here, you may need to enable JavaScript!
Pyridoxal kinase in Human [ChEMBL: CHEMBL1075181] [UniProtKB: O00764] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysophospholipase 1/Acyl-protein thioesterase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681631] [GtoPdb: 3290] [UniProtKB: O75608]
ChEMBL	Inhibition of APT1 (unknown origin) by FluPol-ABPP assay	B	5	pKi	>10000	nM	Ki	Medchemcomm (2014) 5: 268-276 [PMID:25558349]
lysophospholipase 2/Acyl-protein thioesterase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1932891] [GtoPdb: 3291] [UniProtKB: O95372]
ChEMBL	Inhibition of APT2 (unknown origin) by FluPol-ABPP assay	B	6.64	pKi	230	nM	Ki	Medchemcomm (2014) 5: 268-276 [PMID:25558349]
GtoPdb	-	-	6.64	pKi	230	nM	Ki	Medchemcomm (2014) 5: 268-276 [PMID:25558349]
GtoPdb	-	-	6.92	pKi	120	nM	Ki	ACS Med Chem Lett (2017) 8: 215-220 [PMID:28197315]
ChEMBL	Competitive inhibition of HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) preincubated for 30 mins followed by substrate addition by resorufin dye based acetate hydrolysis assay	B	6.92	pKi	120	nM	Ki	ACS Med Chem Lett (2017) 8: 215-220 [PMID:28197315]
ChEMBL	Inhibition of fluorescein-labeled ML349 binding to HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) after 30 mins by fluorescence polarization assay	B	5.96	pIC50	1100	nM	IC50	ACS Med Chem Lett (2017) 8: 215-220 [PMID:28197315]
Pyridoxal kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075181] [UniProtKB: O00764]
ChEMBL	Inhibition of fluorescein-labeled ML349 binding to HEK293T cells-derived His-tagged PDXK expressed in Escherichia coli BL21(DE3) after 30 mins by fluorescence polarization assay	B	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2017) 8: 215-220 [PMID:28197315]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]