NVP-DKY709 [Ligand Id: 12583] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL5077506
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  • Eukaryotic peptide chain release factor GTP-binding subunit ERF3A in Human [ChEMBL: CHEMBL4523593] [UniProtKB: P15170]
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  • cereblon in Human [GtoPdb: 3086] [UniProtKB: Q96SW2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DNA-binding protein Ikaros in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4739685] [UniProtKB: Q13422]
ChEMBL Induction of IKZF1 degradation in human GripTite 293 MSR cells assessed as reduction in IKZF1 level measured by PathHunter assay B 4.3 pEC50 >50000 nM EC50 US-20210309638-A1. 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof (null)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523593] [UniProtKB: P15170]
ChEMBL Induction of GSPT1 degradation in human GripTite 293 MSR cells assessed as reduction in GSPT1 level measured by PathHunter assay B 4.3 pEC50 >50000 nM EC50 US-20210309638-A1. 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof (null)
cereblon in Human [GtoPdb: 3086] [UniProtKB: Q96SW2]
GtoPdb CRBN binding - 6.89 pIC50 130 nM IC50 Cell Chem Biol (2023) 30: 235-247.e12 [PMID:36863346]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]