lifitegrast [Ligand Id: 7533] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2048028 (Lifitegrast, SAR 1118, SAR-1118, SHP-606, SHP606, Xiidra)
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  • Intercellular adhesion molecule-1 in Human [ChEMBL: CHEMBL3070] [UniProtKB: P05362]
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  • integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human [ChEMBL: CHEMBL2096661] [GtoPdb: 2456, 2451] [UniProtKB: P05107, P05362, P20701]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 4.7 pIC50 >20000 nM IC50 ACS Med Chem Lett (2012) 3: 203-206 [PMID:24900456]
Intercellular adhesion molecule-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3070] [UniProtKB: P05362]
ChEMBL Inhibition of human recombinant ICAM-1 adhesion into human Jurkat cells after 1 hr B 8.53 pIC50 2.98 nM IC50 ACS Med Chem Lett (2012) 3: 203-206 [PMID:24900456]
integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096661] [GtoPdb: 2456, 2451] [UniProtKB: P05107, P05362, P20701]
ChEMBL Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-glucosaminide method in presence of 10% human serum F 7.13 pIC50 74 nM IC50 ACS Med Chem Lett (2012) 3: 203-206 [PMID:24900456]
ChEMBL Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-glucosaminide method F 8.05 pIC50 9 nM IC50 ACS Med Chem Lett (2012) 3: 203-206 [PMID:24900456]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]