WIN35428 [Ligand Id: 4606] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1944829 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Displacement of [3H]WIN35428 from human cloned DAT receptor expressed in human HEK293 cells | B | 7.45 | pKi | 35.48 | nM | Ki | Bioorg Med Chem (2012) 20: 1388-1395 [PMID:22300887] |
| ChEMBL | Displacement of [3H]WIN 35428 from human DAT transiently expressed in COS7 cells | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2020) 63: 2343-2357 [PMID:31661268] |
| GtoPdb | - | - | 7.9 | pKi | 12.5 | nM | Ki | Naunyn Schmiedebergs Arch Pharmacol (1996) 354: 295-304 [PMID:8878059] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
