WIN35428 [Ligand Id: 4606] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1944829 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Displacement of [3H]WIN35428 from human cloned DAT receptor expressed in human HEK293 cells | B | 7.45 | pKi | 35.48 | nM | Ki | Bioorg Med Chem (2012) 20: 1388-1395 [PMID:22300887] |
| ChEMBL | Displacement of [3H]WIN 35428 from human DAT transiently expressed in COS7 cells | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2020) 63: 2343-2357 [PMID:31661268] |
| GtoPdb | - | - | 7.9 | pKi | 12.5 | nM | Ki | Naunyn Schmiedebergs Arch Pharmacol (1996) 354: 295-304 [PMID:8878059] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
