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ChEMBL ligand: CHEMBL2426168 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ATP-dependent DNA helicase Q1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293236] [UniProtKB: P46063] | ||||||||
ChEMBL | Inhibition of RECQ1 (unknown origin) by gel-based DNA unwinding assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5660-5666 [PMID:24012121] |
BLM RecQ like helicase/Bloom syndrome protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293237] [GtoPdb: 3260] [UniProtKB: P54132] | ||||||||
ChEMBL | Inhibition of BLM helicase (unknown origin) assessed as branch migration activity | B | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3006-3013 [PMID:24856061] |
ChEMBL | Inhibition of 5'-biotin labeled duplex forked-DNA binding to BLM (unknown origin) assessed as increase in unbound DNA levels after 1 hr by ELISA | B | 4.46 | pIC50 | 34820 | nM | IC50 | J Med Chem (2019) 62: 3147-3162 [PMID:30827110] |
ChEMBL | Inhibition of BLM helicase (unknown origin) binding to DNA | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3006-3013 [PMID:24856061] |
ChEMBL | Inhibition of His-tagged BLM (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in BLM helicase unwinding activity using 5'-biotin labeled forked-DNA as substrate after 1 hr by PAGE analysis | B | 5.67 | pIC50 | 2150 | nM | IC50 | J Med Chem (2019) 62: 3147-3162 [PMID:30827110] |
GtoPdb | Inhibition of BLM-mediated DNA unwinding | - | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5660-6 [PMID:24012121] |
ChEMBL | Inhibition of BLM (unknown origin) by gel-based DNA unwinding assay | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5660-5666 [PMID:24012121] |
WRN RecQ like helicase/Werner syndrome ATP-dependent helicase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2146312] [GtoPdb: 3259] [UniProtKB: Q14191] | ||||||||
ChEMBL | Inhibition of WRN helicase (unknown origin) | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3006-3013 [PMID:24856061] |
ChEMBL | Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay | B | 5.57 | pIC50 | 2700 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5660-5666 [PMID:24012121] |
GtoPdb | Inhibition of WRN-mediated DNA unwinding | - | 5.57 | pIC50 | 2700 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5660-6 [PMID:24012121] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]