STO609 [Ligand Id: 5274] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1182777
  • eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
  • This target only has 0 pki data point
1 CHEMBL1182777_lig_chart_1 Interferon-induced, double-stranded RNA-activated protein kinase Human
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  • calcium/calmodulin dependent protein kinase kinase 1 in Human [GtoPdb: 1956] [UniProtKB: Q8N5S9]
  • This target only has 0 pki data point
2 CHEMBL1182777_lig_chart_2 calcium/calmodulin dependent protein kinase kinase 1 Human
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  • calcium/calmodulin dependent protein kinase kinase 2 in Human [GtoPdb: 1957] [UniProtKB: Q96RR4]
  • This target only has 0 pki data point
3 CHEMBL1182777_lig_chart_3 calcium/calmodulin dependent protein kinase kinase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
ChEMBL Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay B 7 pIC50 <100 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 4108-4114 [PMID:21632247]
calcium/calmodulin dependent protein kinase kinase 1 in Human [GtoPdb: 1956] [UniProtKB: Q8N5S9]
GtoPdb - - 6.85 pIC50 140 nM IC50 J. Biol. Chem. (2002) 277: 15813-8 [PMID:11867640]
calcium/calmodulin dependent protein kinase kinase 2 in Human [GtoPdb: 1957] [UniProtKB: Q96RR4]
GtoPdb - - 7.4 pIC50 40 nM IC50 J. Biol. Chem. (2002) 277: 15813-8 [PMID:11867640]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]