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ChEMBL ligand: CHEMBL469448 (Carubinose, D-mannose, Mannose, NSC-26247, Seminose) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Adhesin protein fimH in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4837] [UniProtKB: P08191] | ||||||||
ChEMBL | Binding affinity to Escherichia coli FimH | B | 5.64 | pKd | 2300 | nM | Kd | Medchemcomm (2014) 5: 1247-1253 |
Fucose-binding lectin PA-IIL in Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523938] [UniProtKB: Q9HYN5] | ||||||||
ChEMBL | Competitive inhibition of N-(fluorescein-5-yl)-N'-(alpha-L-fucopyranosyl ethylen)-thiocarbamide binding to Pseudomonas aeruginosa PA14 LecB after 8 to 22 hrs by fluorescence polarization assay | B | 4.28 | pIC50 | 52000 | nM | IC50 | J Med Chem (2019) 62: 9201-9216 [PMID:31553873] |
Lectin in Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656/ NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3797020] [UniProtKB: B4EH87] | ||||||||
ChEMBL | Binding affinity to Burkholderia cenocepacia J2315 BC2L-A expressed in Escherichia coli BL21 (DE3) cells by microcalorimetry | B | 5.29 | pKd | 5150 | nM | Kd | Medchemcomm (2016) 7: 519-530 |
ChEMBL | Displacement of N-(fluorescein-5-yl)-N'-(alpha-D-mannopyranosyloxyethyl)-thiocarbamide from Burkholderia cenocepacia J2315 BC2L-A expressed in Escherichia coli BL21 (DE3) cells incubated for 3 to 4 hrs by fluorescence polarization assay | B | 4.97 | pIC50 | 10800 | nM | IC50 | Medchemcomm (2016) 7: 519-530 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]