D-mannose [Ligand Id: 4650] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL469448 (Carubinose, D-mannose, Mannose, NSC-26247, Seminose)
  • Adhesin protein fimH in Escherichia coli [ChEMBL: CHEMBL4837] [UniProtKB: P08191]
There should be some charts here, you may need to enable JavaScript!
  • Fucose-binding lectin PA-IIL in Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) [ChEMBL: CHEMBL4523938] [UniProtKB: Q9HYN5]
There should be some charts here, you may need to enable JavaScript!
  • Lectin in Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656/ NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)) [ChEMBL: CHEMBL3797020] [UniProtKB: B4EH87]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Adhesin protein fimH in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4837] [UniProtKB: P08191]
ChEMBL Binding affinity to Escherichia coli FimH B 5.64 pKd 2300 nM Kd Medchemcomm (2014) 5: 1247-1253
Fucose-binding lectin PA-IIL in Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523938] [UniProtKB: Q9HYN5]
ChEMBL Competitive inhibition of N-(fluorescein-5-yl)-N'-(alpha-L-fucopyranosyl ethylen)-thiocarbamide binding to Pseudomonas aeruginosa PA14 LecB after 8 to 22 hrs by fluorescence polarization assay B 4.28 pIC50 52000 nM IC50 J Med Chem (2019) 62: 9201-9216 [PMID:31553873]
Lectin in Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656/ NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3797020] [UniProtKB: B4EH87]
ChEMBL Binding affinity to Burkholderia cenocepacia J2315 BC2L-A expressed in Escherichia coli BL21 (DE3) cells by microcalorimetry B 5.29 pKd 5150 nM Kd Medchemcomm (2016) 7: 519-530
ChEMBL Displacement of N-(fluorescein-5-yl)-N'-(alpha-D-mannopyranosyloxyethyl)-thiocarbamide from Burkholderia cenocepacia J2315 BC2L-A expressed in Escherichia coli BL21 (DE3) cells incubated for 3 to 4 hrs by fluorescence polarization assay B 4.97 pIC50 10800 nM IC50 Medchemcomm (2016) 7: 519-530

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]