ChEMBL ligand: CHEMBL443 (Acetylsulfamethoxazole, Gantanol, Gantanol-ds, NSC-147832, RO 4-2130, RO-4-2130, Sinomin, STX-608, Sulfamethoxazole, Sulfamethoxazole sodium, Sulfamethoxazolum, Sulfametoxazol, Sulphamethoxazole, Suphamethoxazole, Urobak)
6-phospho-1-fructokinase in Trypanosoma brucei [ChEMBL: CHEMBL5686] [UniProtKB: O15648] There should be some charts here, you may need to enable JavaScript!
Dihydrofolate reductase in Pneumocystis carinii [ChEMBL: CHEMBL1926] [UniProtKB: P16184] There should be some charts here, you may need to enable JavaScript!
Dihydropteroate synthase in Escherichia coli [ChEMBL: CHEMBL4032] [UniProtKB: P0AC13] There should be some charts here, you may need to enable JavaScript!
ETA receptor/Endothelin receptor ET-A in Rat [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
6-phospho-1-fructokinase in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5686] [UniProtKB: O15648]
ChEMBL	Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay	B	4.24	pIC50	>57000	nM	IC50	ACS Med Chem Lett (2014) 5: 12-17 [PMID:24900769]
Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184]
ChEMBL	Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii in the prence of 100 micro M PABA.	B	7	pIC50	100	nM	IC50	J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
Dihydropteroate synthase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4032] [UniProtKB: P0AC13]
ChEMBL	In vitro inhibition of dihydropteroate synthase from Escherichia coli.	B	5.33	pIC50	4700	nM	IC50	J Med Chem (1985) 28: 1870-1874 [PMID:3906132]
ETA receptor/Endothelin receptor ET-A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684]
ChEMBL	Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.	B	5.4	pIC50	4000	nM	IC50	J Med Chem (1995) 38: 1344-1354 [PMID:7731020]
ChEMBL	Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells	B	5.4	pIC50	4000	nM	IC50	J Med Chem (1995) 38: 659-668 [PMID:7861414]
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL	Binding affinity for human immunodeficiency virus type 1 protease	B	6.24	pKd	577	nM	Kd	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]
ChEMBL	Inhibition constant for human immunodeficiency virus type 1 protease	B	8	pKi	10.1	nM	Ki	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]