ChEMBL ligand: CHEMBL443 (Acetylsulfamethoxazole, Gantanol, Gantanol-ds, NSC-147832, RO 4-2130, RO-4-2130, Sinomin, STX-608, Sulfamethoxazole, Sulfamethoxazole sodium, Sulfamethoxazolum, Sulphamethoxazole, Suphamethoxazole, Urobak)
6-phospho-1-fructokinase in Trypanosoma brucei [ChEMBL: CHEMBL5686] [UniProtKB: O15648] There should be some charts here, you may need to enable JavaScript!
Dihydrofolate reductase in Pneumocystis carinii [ChEMBL: CHEMBL1926] [UniProtKB: P16184] There should be some charts here, you may need to enable JavaScript!
Dihydropteroate synthase in Escherichia coli [ChEMBL: CHEMBL4032] [UniProtKB: P0AC13] There should be some charts here, you may need to enable JavaScript!
ETA receptor/Endothelin receptor ET-A in Rat [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
6-phospho-1-fructokinase in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5686] [UniProtKB: O15648]
ChEMBL	Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay	B	4.24	pIC50	>57000	nM	IC50	ACS Med Chem Lett (2014) 5: 12-17 [PMID:24900769]
Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184]
ChEMBL	Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii in the prence of 100 micro M PABA.	B	7	pIC50	100	nM	IC50	J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
Dihydropteroate synthase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4032] [UniProtKB: P0AC13]
ChEMBL	In vitro inhibition of dihydropteroate synthase from Escherichia coli.	B	5.33	pIC50	4700	nM	IC50	J Med Chem (1985) 28: 1870-1874 [PMID:3906132]
ETA receptor/Endothelin receptor ET-A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684]
ChEMBL	Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.	B	5.4	pIC50	4000	nM	IC50	J Med Chem (1995) 38: 1344-1354 [PMID:7731020]
ChEMBL	Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells	B	5.4	pIC50	4000	nM	IC50	J Med Chem (1995) 38: 659-668 [PMID:7861414]
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL	Binding affinity for human immunodeficiency virus type 1 protease	B	6.24	pKd	577	nM	Kd	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]
ChEMBL	Inhibition constant for human immunodeficiency virus type 1 protease	B	8	pKi	10.1	nM	Ki	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]