ChEMBL ligand: CHEMBL1163 (Atazanavir, BMS-232632, CGP-73547, Reyataz)
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12] There should be some charts here, you may need to enable JavaScript!
UDP glucuronosyltransferase family 1 member A1/UDP-glucuronosyltransferase 1-1 in Human [ChEMBL: CHEMBL1287617] [GtoPdb: 2990] [UniProtKB: P22309] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	Inhibition of human ABCG2 expressed in dog MDCK-II-BCRP cells mediated pheophorbide A efflux preincubated with PhA followed by compound addition and measured after 60 mins by flow cytometry	B	4.16	pIC50	69100	nM	IC50	Eur J Med Chem (2022) 237: 114346-114346 [PMID:35483322]
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL	Binding affinity for human immunodeficiency virus type 1 protease	B	9.4	pKd	0.4	nM	Kd	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]
ChEMBL	Inhibition of HIV1 recombinant protease L10I/L24I/L33F/M46L/154V/L63P/A71V/V82A/I84V mutant expressed in Escherichia coli by spectrophotometric assay	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2008) 51: 4839-4843 [PMID:18598016]
ChEMBL	Inhibition of HIV1 recombinant protease M46I/A71V/V82T/I84V mutant expressed in Escherichia coli by spectrophotometric assay	B	9.12	pKi	0.76	nM	Ki	J Med Chem (2008) 51: 4839-4843 [PMID:18598016]
ChEMBL	Inhibition constant for human immunodeficiency virus type 1 protease	B	9.62	pKi	0.24	nM	Ki	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]
ChEMBL	Inhibition of HIV1 recombinant protease A71V/V82T/I84V mutant expressed in Escherichia coli by spectrophotometric assay	B	9.64	pKi	0.23	nM	Ki	J Med Chem (2008) 51: 4839-4843 [PMID:18598016]
ChEMBL	Inhibition of HIV1 recombinant protease V32I/I47A mutant expressed in Escherichia coli by spectrophotometric assay	B	9.77	pKi	0.17	nM	Ki	J Med Chem (2008) 51: 4839-4843 [PMID:18598016]
ChEMBL	Inhibition of HIV1 recombinant protease L10I/I15V/E35D/N37S/R41K/I62V/L63P/A71V/G73S/L90M mutant expressed in Escherichia coli by spectrophotometric assay	B	10.12	pKi	0.08	nM	Ki	J Med Chem (2008) 51: 4839-4843 [PMID:18598016]
ChEMBL	Inhibition of HIV1 recombinant protease D30N/N88D mutant expressed in Escherichia coli by spectrophotometric assay	B	10.26	pKi	0.06	nM	Ki	J Med Chem (2008) 51: 4839-4843 [PMID:18598016]
ChEMBL	Inhibition of HIV1 recombinant protease L10F/L19I/K20R/L33F/E35D/M36I/R41K/F53L/I54V/L63P/H69K/A71V/T74P/I84V/L89M/L90M/I93L mutant expressed in Escherichia coli by spectrophotometric assay	B	10.27	pKi	0.05	nM	Ki	J Med Chem (2008) 51: 4839-4843 [PMID:18598016]
ChEMBL	Inhibition of HIV1 subtype C protease Q7K mutant expressed in Escherichia coli BL21 (DE3) pLysS using Lys-Ala-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle-NH2 as substrate by spectrophotometry	B	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2011) 46: 3976-3985 [PMID:21741133]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL	The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.	B	7.59	pIC50	26	nM	IC50	J Med Chem (1998) 41: 3387-3401 [PMID:9719591]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cells	B	4.17	pIC50	67800	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3498-3504 [PMID:17664327]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	5.1	pIC50	7950	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12]
ChEMBL	Inhibition of HIV1 protease expressed in Escherichia coli using DABCYL-Abu-Ser-Gln-ASN-Tyr-Pro-Ile-Val-Gln-EDANS as substrate preincubated for 20 mins measured for 45 mins by fluorometry	B	8.57	pKi	2.7	nM	Ki	J Med Chem (2012) 55: 2724-2736 [PMID:22376008]
ChEMBL	Inhibition of HIV1 protease expressed in Escherichia coli	B	8.57	pKi	2.7	nM	Ki	J Med Chem (2008) 51: 1053-1057 [PMID:18215014]
ChEMBL	Inhibition of HIV1 RF protease expressed in Escherichia coli BL21 (DE3) using DABCYL-delta-Abu-Ser-Gln-ASN-Tyr-Pro-Ile-Val-Gln-EDANS as substrate after 30 mins by fluorescence assay	B	8.57	pKi	2.7	nM	Ki	Medchemcomm (2011) 2: 701-709
ChEMBL	Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assay	B	9.3	pKi	0.5	nM	Ki	J Med Chem (2010) 53: 607-615 [PMID:19961222]
ChEMBL	Inhibition of HIV1 protease	B	10.3	pKi	0.05	nM	Ki	Bioorg Med Chem (2008) 16: 1299-1308 [PMID:17981045]
ChEMBL	Inhibition of HIV1 protease using fluorogenic hexapeptide substrate (2-aminobenzoyl)Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg by fluorimeter	B	10.32	pKi	0.05	nM	Ki	Medchemcomm (2011) 2: 1093-1098
ChEMBL	Inhibition of HIV1 protease	B	10.41	pKi	0.04	nM	Ki	Antimicrob Agents Chemother (2007) 51: 4036-4043 [PMID:17638694]
ChEMBL	Inhibition of wild-type HIV1 BH10 protease expressed in Escherichia coli by spectrophotometric assay	B	10.62	pKi	0.02	nM	Ki	J Med Chem (2008) 51: 4839-4843 [PMID:18598016]
ChEMBL	Inhibition of HIV1 subtype C protease expressed in Escherichia coli BL21 assessed as hydrolysis of substrate using chromogenic substrate Lys-Ala-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle-NH2 by spectrophotometric analysis	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2274-2277 [PMID:21429747]
ChEMBL	Inhibition of South African HIV1 subtype C protease expressed in Escherichia coli BL21S4 (DE3)pLysS cells using Lys-Ala-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle-NH2 as substrate by spectrophotometry	B	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2012) 53: 13-21 [PMID:22542107]
ChEMBL	Inhibition of wild type C-South African Human immunodeficiency virus 1 protease using chromogenic peptide H-1048 as substrate by UV spectrophotometric analysis	B	8.4	pIC50	4	nM	IC50	Med Chem Res (2013) 22: 3918-3933
ChEMBL	Inhibition of HIV1 protease activity	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2019) 62: 3553-3574 [PMID:30938524]
ChEMBL	Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by addition of Val-Ser-Gln-Asn-(beta-naphtyl)Ala-Pro-Ile-Val as substrate measured after 1 hr	B	10.4	pIC50	0.04	nM	IC50	ACS Med Chem Lett (2016) 7: 702-707 [PMID:27437081]
ChEMBL	Inhibition of HIV1 protease expressed in Escherichia coli using Val-Ser-Gln-Asn-(beta-naphtyl)Ala-Pro-Ile-Val as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by mass spectrometric method	B	10.4	pIC50	0.04	nM	IC50	ACS Med Chem Lett (2017) 8: 1292-1297 [PMID:29259750]
ChEMBL	Inhibition of HIV1 NL4-3 protease assessed as decrease in viral replication in human MT2 cells after 4 days by luciferase reporter gene assay	B	9.15	pEC50	0.7	nM	EC50	J Med Chem (2018) 61: 4176-4188 [PMID:29693401]
UDP glucuronosyltransferase family 1 member A1/UDP-glucuronosyltransferase 1-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287617] [GtoPdb: 2990] [UniProtKB: P22309]
ChEMBL	Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate incubated for 40 mins by LC-MS/MS analysis	B	6.22	pIC50	600	nM	IC50	J Med Chem (2022) 65: 11150-11176 [PMID:35952307]
ChEMBL	Inhibition of human recombinant UGT1A1 using bilirubin as substrate incubated for 40 mins by LC-MS/MS analysis	B	6.52	pIC50	300	nM	IC50	J Med Chem (2022) 65: 11150-11176 [PMID:35952307]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]