ulimorelin [Ligand Id: 3535] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1963249 (TZP-101 FREE BASE, Ulimorelin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847] | ||||||||
| ChEMBL | Agonist activity at ghrelin receptor | F | 7.57 | pEC50 | 27 | nM | EC50 | J Med Chem (2011) 54: 1961-2004 [PMID:21381769] |
| ChEMBL | Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay | F | 8.3 | pEC50 | 5 | nM | EC50 | US-8450268-B2. Methods of using macrocyclic modulators of the ghrelin receptor (2013) |
| ChEMBL | Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay | F | 9 | pEC50 | 1 | nM | EC50 | US-8450268-B2. Methods of using macrocyclic modulators of the ghrelin receptor (2013) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
