naloxone [Ligand Id: 1638] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL80 (Dbl naloxone, Nalone, Naloxone, Narcan, Narcanti, NSC-70413, Suboxone) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| ChEMBL | Binding affinity to adenosine receptor A1 | B | 4.3 | pKi | >50000 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6736-6739 [PMID:19836950] |
| CCR5/C-C chemokine receptor type 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3676] [GtoPdb: 62] [UniProtKB: P51682] | ||||||||
| ChEMBL | Binding affinity to CCR5 in C57BL/6J mouse brain membrane | B | 7.68 | pKd | 20.8 | nM | Kd | Proc Natl Acad Sci U S A (2007) 104: 6061-6065 [PMID:17389363] |
| ChEMBL | Binding affinity to CCR5 in NY1DD transgenic mouse brain membrane | B | 7.98 | pKd | 10.5 | nM | Kd | Proc Natl Acad Sci U S A (2007) 104: 6061-6065 [PMID:17389363] |
| CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.7 | pIC50 | 2000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Displacement of [3H]DPDPE from human DOR expressed in HEK293 cells after 60 mins by scintillation counting analysis | B | 5.82 | pKi | 1516 | nM | Ki | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
| ChEMBL | DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) | B | 6.29 | pKi | 515 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells | B | 6.92 | pKi | 120 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293] |
| ChEMBL | Displacement of [3H]diprenorphine human delta opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting method | B | 6.92 | pKi | 120 | nM | Ki | ACS Med Chem Lett (2020) 11: 720-726 [PMID:32435376] |
| ChEMBL | Displacement of [3H]deltrophine from human delta opioid receptor expressed in CHO-K1 cells after 120 mins by liquid scintillation counting method | B | 6.99 | pKi | 103 | nM | Ki | Medchemcomm (2016) 7: 317-326 |
| ChEMBL | Displacement of [3H]-deltorphine from human delta opioid receptor expressed in CHO-K1 cells by scintillation counting analysis | B | 6.99 | pKi | 103 | nM | Ki | J Med Chem (2014) 57: 6845-6860 [PMID:25062506] |
| ChEMBL | Displacement of [3H]-diprenorphine from human delta opioid receptor expressed in CHO cell membranes incubated for 1 hr by competition radioligand binding assay | B | 7.01 | pKi | 98.1 | nM | Ki | J Med Chem (2020) 63: 7663-7694 [PMID:32530286] |
| ChEMBL | Displacement of [3H]naltrindole from human opioid delta receptor expressed in CHO cells | B | 7.12 | pKi | 76 | nM | Ki | J Med Chem (2007) 50: 2254-2258 [PMID:17407276] |
| ChEMBL | Displacement of [3H]-diprenorphine from human DOR expressed in CHO cell membranes incubated for 1 hr by scintillation counting method | B | 7.14 | pKi | 72.8 | nM | Ki | J Med Chem (2020) 63: 2673-2687 [PMID:31834798] |
| ChEMBL | Displacement of [3H]-diprenorphine from human delta opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation counting method | B | 7.15 | pKi | 70 | nM | Ki | ACS Med Chem Lett (2019) 10: 450-456 [PMID:30996778] |
| GtoPdb | - | - | 7.2 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
| ChEMBL | Displacement of [125I]OXY from human delta opioid receptor expressed in CHO cells | B | 7.29 | pKi | 51 | nM | Ki | J Med Chem (2010) 53: 1392-1396 [PMID:20055417] |
| ChEMBL | Displacement of [3H]DPDPE from delta opioid receptor | B | 7.37 | pKi | 42.6 | nM | Ki | J Nat Prod (1993) 56: 441-455 [PMID:8496700] |
| ChEMBL | Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1 in CHO cells | B | 7.39 | pKi | 41 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 523-526 [PMID:10741545] |
| ChEMBL | Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cells after 3 hrs by scintillation counting | B | 7.42 | pKi | 38 | nM | Ki | Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470] |
| ChEMBL | In vitro binding affinity to human Opioid receptor delta 1 on CHO cell membranes using [3H]diprenorphine displacement. | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2003) 46: 2104-2109 [PMID:12747782] |
| ChEMBL | Concentration required to inhibit the binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human delta opioid receptor | B | 7.48 | pKi | 33 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 4459-4462 [PMID:14643346] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned delta opioid receptor | B | 7.48 | pKi | 33 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2006-2012 [PMID:18313920] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned delta opioid receptor expressed in CHO cells | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2006) 49: 7278-7289 [PMID:17149858] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned delta opioid receptor expressed in CHO cells | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2006) 49: 7290-7306 [PMID:17149859] |
| ChEMBL | Displacement of [3H]DPDPE from delta opioid receptor (unknown origin) transfected into HEK293 cells by microplate scintillation counting | B | 7.52 | pKi | 30 | nM | Ki | J Nat Prod (2015) 78: 1461-1465 [PMID:26035635] |
| ChEMBL | Displacement of [3H]DPN from human recombinant delta-type opioid receptor expressed in CHO cell membranes | B | 7.67 | pKi | 21.38 | nM | Ki | Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931] |
| ChEMBL | In vivo binding affinity against delta Opioid receptor was measured by using labeled ligand [3H]DADLE (1 nM) with 4 nM sufentanil | B | 7.72 | pKi | 19 | nM | Ki | J Med Chem (1994) 37: 3121-3127 [PMID:7932535] |
| ChEMBL | Binding affinity to delta-opioid receptor (unknown origin) | B | 7.8 | pKi | 15.85 | nM | Ki | J Nat Prod (2021) 84: 713-723 [PMID:32870011] |
| ChEMBL | DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) | B | 5.84 | pIC50 | 1461 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at human delta opioid receptor expressed in CHO cell membranes assessed as reduction in SNC80-induced [35S]GTPgammaS binding preincubated for 5 mins followed by SNC80 addition and measured after 1 hr | F | 6.82 | pIC50 | 153 | nM | IC50 | J Med Chem (2020) 63: 7663-7694 [PMID:32530286] |
| ChEMBL | Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligand | B | 6.82 | pIC50 | 151 | nM | IC50 | J Med Chem (2001) 44: 3378-3390 [PMID:11585443] |
| ChEMBL | Antagonist activity at human delta opioid receptor expressed in CHO cell membranes assessed as reduction in SNC80-induced [35S]GTPgammaS binding incubated for 1 hr | F | 6.84 | pIC50 | 146 | nM | IC50 | ACS Med Chem Lett (2019) 10: 450-456 [PMID:30996778] |
| ChEMBL | Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK cell membrane | B | 6.86 | pIC50 | 138 | nM | IC50 | J Nat Prod (2007) 70: 866-868 [PMID:17388627] |
| ChEMBL | Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK cells | B | 6.86 | pIC50 | 138 | nM | IC50 | J Nat Prod (2007) 70: 1946-1950 [PMID:18039010] |
| ChEMBL | Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK293 cells | B | 6.86 | pIC50 | 138 | nM | IC50 | J Nat Prod (2006) 69: 1295-1299 [PMID:16989522] |
| ChEMBL | Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK cell membranes | B | 6.86 | pIC50 | 138 | nM | IC50 | J Nat Prod (2007) 70: 872-875 [PMID:17451272] |
| ChEMBL | Antagonist activity at human DOR expressed in CHO cell membranes assessed as reduction in SNC80-induced response incubated for 1 hr by [35S]-GTPgammaS coupling assay | F | 7.11 | pIC50 | 78.2 | nM | IC50 | J Med Chem (2020) 63: 2673-2687 [PMID:31834798] |
| ChEMBL | Inhibition of Opioid receptor delta 1 by displacing 1 nM [3H]DPDPE in guinea pig brain membrane | B | 7.21 | pIC50 | 62 | nM | IC50 | J Med Chem (1992) 35: 4589-4594 [PMID:1335078] |
| ChEMBL | Inhibition of [3H]DPDPE binding to guinea pig brain membrane Opioid receptor delta 1 at 1.0 nM | B | 7.21 | pIC50 | 62 | nM | IC50 | J Med Chem (1992) 35: 2374-2384 [PMID:1320121] |
| δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] | ||||||||
| ChEMBL | Tested for inhibitory activity against (DPDE)delta receptor in mouse vas deferens | B | 7.3 | pKd | 50.12 | nM | Kd | J Med Chem (1994) 37: 2262-2265 [PMID:8057274] |
| ChEMBL | Antagonist activity at delta opioid receptor in Swiss mouse vas deferens assessed as reversal of DSLET effect on electrically-induced driven twitch | F | 7.35 | pKd | 44.67 | nM | Kd | Bioorg Med Chem (2008) 16: 869-873 [PMID:17962026] |
| GtoPdb | - | - | 7.8 | pKi | - | - | - | Mol Pharmacol (1994) 45: 330-4 [PMID:8114680] |
| GtoPdb | - | - | 6.2 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1993) 90: 6736-40 [PMID:8393575] |
| δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] | ||||||||
| ChEMBL | Affinity against the Opioid receptor delta 1 | B | 7.74 | pKd | 18 | nM | Kd | J Med Chem (1986) 29: 531-537 [PMID:3007760] |
| ChEMBL | Displacement of [3H]DPDPE from DOR in Sprague-Dawley rat brain membranes after 120 mins by scintillation counting method | B | 6.99 | pKi | 103 | nM | Ki | J Med Chem (2019) 62: 893-907 [PMID:30543421] |
| ChEMBL | Binding affinity towards delta-opioid receptor by displacement of [3H]DADL in rat brain homogenates | B | 7.49 | pKi | 32 | nM | Ki | J Med Chem (1993) 36: 2842-2850 [PMID:8410999] |
| ChEMBL | Displacement of [3H]-DPDPE from delta opioid receptor in rat brain membrane after 120 mins by scintillation counting | B | 8.6 | pKi | 2.5 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5326-5330 [PMID:26411794] |
| ChEMBL | Displacement of [3H]DPDPE from delta opioid receptor in Sprague-Dawley rat brain membranes after 120 mins by scintillation counting analysis | B | 8.62 | pKi | 2.4 | nM | Ki | Medchemcomm (2016) 7: 2368-2380 |
| ChEMBL | Displacement of [3H]DPDPE from delta opioid receptor in rat membranes after 120 mins by scintillation counting analysis | B | 8.62 | pKi | 2.4 | nM | Ki | J Med Chem (2019) 62: 4204-4217 [PMID:30939014] |
| D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
| ChEMBL | Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells. | B | 4.7 | pKi | >20000 | nM | Ki | J Med Chem (1993) 36: 1499-1500 [PMID:8098771] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Displacement of [3H]U-69593 from human KOR expressed in HEK293 cells after 60 mins by scintillation counting analysis | B | 6.44 | pKi | 362 | nM | Ki | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
| ChEMBL | DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) | B | 7.52 | pKi | 30 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Binding affinity to kappa-opioid receptor (unknown origin) | B | 7.8 | pKi | 15.85 | nM | Ki | J Nat Prod (2021) 84: 713-723 [PMID:32870011] |
| ChEMBL | Displacement of [3H]Cl-977 from human kappa opioid receptor expressed on HEK-293 cells by liquid scintillation counting method | B | 7.82 | pKi | 15 | nM | Ki | Medchemcomm (2016) 7: 317-326 |
| ChEMBL | Displacement of [3H]Cl977 from human kappa opioid receptor expressed in HEK293 cells | B | 7.83 | pKi | 14.7 | nM | Ki | J Med Chem (2010) 53: 4212-4222 [PMID:20441176] |
| ChEMBL | In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement. | B | 7.97 | pKi | 10.7 | nM | Ki | J Med Chem (2003) 46: 2104-2109 [PMID:12747782] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned kappa opioid receptor | B | 8.04 | pKi | 9.2 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2006-2012 [PMID:18313920] |
| ChEMBL | Binding affinity at cloned human kappa opioid receptor by [3H]diprenorphine displacement. | B | 8.04 | pKi | 9.2 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 4459-4462 [PMID:14643346] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned kappa opioid receptor expressed in CHO cells | B | 8.04 | pKi | 9.2 | nM | Ki | J Med Chem (2006) 49: 7290-7306 [PMID:17149859] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned kappa opioid receptor expressed in CHO cells | B | 8.04 | pKi | 9.2 | nM | Ki | J Med Chem (2006) 49: 7278-7289 [PMID:17149858] |
| ChEMBL | Displacement of [3H]DPN from human recombinant kappa-type opioid receptor expressed in CHO cell membranes | B | 8.35 | pKi | 4.47 | nM | Ki | Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931] |
| ChEMBL | Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cells | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2010) 53: 1392-1396 [PMID:20055417] |
| GtoPdb | - | - | 8.6 | pKi | - | - | - |
NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]; Binding and activity of opioid ligands at the cloned human delta, mu and kappa receptors.. The Delta Receptor (2003); Life Sci (1995) 56: PL201-PL207 [PMID:7869844]; Proc Natl Acad Sci USA (1995) 92: 7006-10 [PMID:7624359]; J Pharmacol Exp Ther (1997) 282: 676-84 [PMID:9262330] |
| ChEMBL | Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells | B | 8.92 | pKi | 1.2 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293] |
| ChEMBL | Inhibition of [3H]U-69593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells | B | 8.92 | pKi | 1.2 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 523-526 [PMID:10741545] |
| ChEMBL | Displacement of [3H]U-69593 from human opioid kappa receptor expressed in CHO cells | B | 8.96 | pKi | 1.1 | nM | Ki | J Med Chem (2007) 50: 2254-2258 [PMID:17407276] |
| ChEMBL | Displacement of [3H]U69563 from human kappa-opioid receptor expressed in CHO cells after 60 mins by scintillation counting | B | 9.6 | pKi | 0.25 | nM | Ki | Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470] |
| ChEMBL | Antagonist activity at human opioid kappa receptor expressed in CHO cells assessed as inhibition of U-50488-stimulated [35S]GTP-gamma-S binding | F | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2007) 50: 2254-2258 [PMID:17407276] |
| ChEMBL | Antagonist activity at human KOR expressed in CHO cell membranes assessed as reduction in U50,488 induced response incubated for 1 hr by liquid scintillation counting based [35S]GTP-gamma-S assay | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (2016) 59: 10291-10298 [PMID:27797517] |
| ChEMBL | DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) | B | 7.12 | pIC50 | 75 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonistic activity in the Opioid receptor kappa 1-mediated [35S]GTP-gamma-S, binding assay against 50 nM U-50,488 | F | 7.3 | pIC50 | 49.8 | nM | IC50 | J Med Chem (2003) 46: 2104-2109 [PMID:12747782] |
| ChEMBL | Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (2001) 44: 3378-3390 [PMID:11585443] |
| ChEMBL | Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2007) 50: 2254-2258 [PMID:17407276] |
| ChEMBL | Effective concentration for half-maximal stimulation was determined by [35S]GTP-gamma-S, assay | F | 8.18 | pEC50 | 6.6 | nM | EC50 | J Med Chem (2003) 46: 2104-2109 [PMID:12747782] |
| κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] | ||||||||
| ChEMBL | Antagonist activity at kappa opioid receptor in Swiss mouse vas deferens assessed as reversal of U50488 effect on electrically-induced driven twitch | F | 6.9 | pKd | 125.89 | nM | Kd | Bioorg Med Chem (2008) 16: 869-873 [PMID:17962026] |
| GtoPdb | - | - | 8.3 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1993) 90: 6736-40 [PMID:8393575] |
| κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] | ||||||||
| ChEMBL | Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the cDNAs for rat Opioid receptor kappa 1 | B | 8.35 | pKd | 4.5 | nM | Kd | Bioorg Med Chem Lett (2000) 10: 831-834 [PMID:10782696] |
| ChEMBL | Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa) | B | 9 | pKd | 1 | nM | Kd | J Med Chem (1986) 29: 531-537 [PMID:3007760] |
| GtoPdb | - | - | 8 | pKi | - | - | - |
Biochem J (1993) 295 ( Pt 3): 625-8 [PMID:8240267]; Biochem J (1993) 295 ( Pt 3): 629-33 [PMID:8240268]; Proc Natl Acad Sci USA (1993) 90: 9954-8 [PMID:8234341] |
| Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144] | ||||||||
| ChEMBL | Tested for its antagonist activity against kappa receptor using U-69,593 as radioligand in isolated guinea pig ileum | F | 7.7 | pKd | 19.95 | nM | Kd | J Med Chem (1994) 37: 2262-2265 [PMID:8057274] |
| ChEMBL | Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at from guinea pig cortical tissue | B | 7.18 | pKi | 66 | nM | Ki | J Med Chem (1993) 36: 2833-2841 [PMID:8410998] |
| ChEMBL | Binding affinity towards kappa opioid receptor by displacement of [3H]EKC in guinea pig cortical tissue | B | 7.18 | pKi | 66 | nM | Ki | J Med Chem (1993) 36: 2842-2850 [PMID:8410999] |
| ChEMBL | Tested for binding affinity towards kappa receptor in presence of [3H]EKC radioligand | B | 7.18 | pKi | 66 | nM | Ki | J Med Chem (1994) 37: 2262-2265 [PMID:8057274] |
| ChEMBL | Displacement of [3H]Cl-977 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysis | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2014) 57: 6845-6860 [PMID:25062506] |
| ChEMBL | In vivo binding affinity against kappa opioid receptor was measured by using labeled ligand [3H]ethylketocyclazocine (1 nM) with 500 nM DADLE and 20 nM sufentanil | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (1994) 37: 3121-3127 [PMID:7932535] |
| ChEMBL | Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysis | B | 8.14 | pKi | 7.3 | nM | Ki | J Med Chem (2014) 57: 6845-6860 [PMID:25062506] |
| ChEMBL | Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membrane after 150 mins by scintillation counting | B | 8.14 | pKi | 7.3 | nM | Ki | J Med Chem (2010) 53: 4212-4222 [PMID:20441176] |
| ChEMBL | Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membranes after 150 mins by scintillation counting | B | 8.14 | pKi | 7.3 | nM | Ki | Eur J Med Chem (2011) 46: 1972-1982 [PMID:21481987] |
| ChEMBL | Displacement of [3H]U-69,593 from kappa-type opioid receptor in guinea pig brain membranes after 120 mins by solid scintillation counting | B | 8.14 | pKi | 7.3 | nM | Ki | J Med Chem (2017) 60: 2526-2551 [PMID:28218838] |
| ChEMBL | Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting method | B | 8.14 | pKi | 7.3 | nM | Ki | J Med Chem (2019) 62: 893-907 [PMID:30543421] |
| ChEMBL | Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting analysis | B | 8.16 | pKi | 6.9 | nM | Ki | J Med Chem (2019) 62: 4204-4217 [PMID:30939014] |
| ChEMBL | Displacement of [3H]-U-69593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting | B | 8.16 | pKi | 6.9 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5326-5330 [PMID:26411794] |
| ChEMBL | Displacement of [3H]U-69593 from kappa-opioid receptor in guinea pig brain membrane | B | 8.16 | pKi | 6.9 | nM | Ki | Bioorg Med Chem (2014) 22: 3316-3324 [PMID:24856182] |
| ChEMBL | Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis | B | 8.16 | pKi | 6.9 | nM | Ki | Medchemcomm (2016) 7: 2368-2380 |
| ChEMBL | Affinity to opioid receptor kappa 1 using [3H]U-69593 as radioligand in homogenates of guinea pig brain membranes | B | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (2001) 44: 2814-2826 [PMID:11495592] |
| ChEMBL | Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membrane | B | 8.5 | pKi | 3.17 | nM | Ki | Eur J Med Chem (2007) 42: 1247-1262 [PMID:17420073] |
| ChEMBL | Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig brain membarnes by liquid scintillation counting method | B | 8.51 | pKi | 3.1 | nM | Ki | Medchemcomm (2016) 7: 317-326 |
| ChEMBL | Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membrane | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1992) 35: 4589-4594 [PMID:1335078] |
| ChEMBL | Displacement of 0.5 nM [3H]bremazocine from guinea pig brain membrane opioid receptor kappa with 100 nM DAGO and 100 nM DPDPE | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1992) 35: 2374-2384 [PMID:1320121] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Antagonist activity against mu opioid receptor assessed as effect on endomorphin-2-induced calcium response in CHO cells by aequorin luminescence based calcium assay | F | 9.66 | pKd | 0.22 | nM | Kd | J Med Chem (2007) 50: 512-520 [PMID:17266203] |
| ChEMBL | Antagonist activity at mu opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay | F | 9.66 | pKd | 0.22 | nM | Kd | Bioorg Med Chem Lett (2008) 18: 1350-1353 [PMID:18207400] |
| ChEMBL | Displacement of [3H]DAMGO from human MOR expressed in HEK293 cells after 60 mins by scintillation counting analysis | B | 6.45 | pKi | 354 | nM | Ki | J Med Chem (2014) 57: 8903-8927 [PMID:25268943] |
| ChEMBL | Displacement of [3H]-diprenorphine from human mu opioid receptor expressed in CHO cell membranes incubated for 1 hr by competition radioligand binding assay | B | 7.23 | pKi | 59.5 | nM | Ki | J Med Chem (2020) 63: 7663-7694 [PMID:32530286] |
| ChEMBL | Displacement of [3H]-diprenorphine from human mu opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation counting method | B | 7.29 | pKi | 51.2 | nM | Ki | ACS Med Chem Lett (2019) 10: 450-456 [PMID:30996778] |
| ChEMBL | Displacement of [3H]-diprenorphine from human MOR expressed in CHO cell membranes incubated for 1 hr by scintillation counting method | B | 7.29 | pKi | 51 | nM | Ki | J Med Chem (2020) 63: 2673-2687 [PMID:31834798] |
| ChEMBL | Displacement of [3H]diprenorphine human MOR expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting method | B | 7.37 | pKi | 43 | nM | Ki | ACS Med Chem Lett (2020) 11: 720-726 [PMID:32435376] |
| ChEMBL | DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) | B | 8.09 | pKi | 8.06 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Displacement of [125I]-IBNtxA from MOR-1 expressed in CHO cells | B | 8.37 | pKi | 4.23 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4001-4004 [PMID:21621410] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cells | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (2006) 49: 7278-7289 [PMID:17149858] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cells | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (2006) 49: 7290-7306 [PMID:17149859] |
| ChEMBL | Inhibition of binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human mu opioid receptor | B | 8.43 | pKi | 3.7 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 4459-4462 [PMID:14643346] |
| ChEMBL | Displacement of [3H]diprenorphine from human cloned mu opioid receptor | B | 8.43 | pKi | 3.7 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2006-2012 [PMID:18313920] |
| ChEMBL | In vitro binding affinity to human Opioid receptor mu 1 on CHO cell membranes using [3H]diprenorphine displacement. | B | 8.44 | pKi | 3.63 | nM | Ki | J Med Chem (2003) 46: 2104-2109 [PMID:12747782] |
| ChEMBL | Displacement of [3H]-naloxone from human mu opioid receptor expressed in CHO-K1 cells by scintillation counting analysis | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (2014) 57: 6845-6860 [PMID:25062506] |
| ChEMBL | Displacement of [3H]naloxone from human mu opioid receptor expressed in CHO-K1 cells after 150 mins by liquid scintillation counting method | B | 8.64 | pKi | 2.3 | nM | Ki | Medchemcomm (2016) 7: 317-326 |
| ChEMBL | Displacement of [125I]-IBNalA from MOR-1 expressed in CHO cells | B | 8.64 | pKi | 2.27 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4001-4004 [PMID:21621410] |
| ChEMBL | Displacement of [3H]DAGO from mu opioid receptor | B | 8.8 | pKi | 1.6 | nM | Ki | J Nat Prod (1993) 56: 441-455 [PMID:8496700] |
| ChEMBL | Binding affinity to mu opioid receptor | B | 8.82 | pKi | 1.5 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6736-6739 [PMID:19836950] |
| ChEMBL | Displacement of [3H]DAMGO from human MOR expressed in HEK293 cells preincubated for 1 hr followed by radioligand addition measured after 1 hr by liquid scintillation counting analysis | B | 8.9 | pKi | 1.26 | nM | Ki | J Med Chem (2015) 58: 9754-9767 [PMID:26632862] |
| GtoPdb | - | - | 8.9 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
| ChEMBL | Displacement of 2-((1E,3E,5E)-5-(1-Ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)-penta-1,3-dien-1-yl)-1-(6-((6-((6S,7R,7aR,12bS)-9-hydroxy-7-methoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline-6-carboxamido)hexyl)-amino)-6-oxohexyl)-3,3-dimethyl-3H-indol-1-ium-5-sulfonate,2,2,2-Trifluoroacetate Salt from human MOR expressed in HEK293 cells by Cheng-Prusoff analysis | B | 8.94 | pKi | 1.15 | nM | Ki | J Med Chem (2015) 58: 9754-9767 [PMID:26632862] |
| ChEMBL | Binding affinity to mu-opioid receptor (unknown origin) | B | 9 | pKi | 1 | nM | Ki | J Nat Prod (2021) 84: 713-723 [PMID:32870011] |
| ChEMBL | Displacement of [125I]OXY from human mu opioid receptor expressed in CHO cells | B | 9.01 | pKi | 0.98 | nM | Ki | J Med Chem (2010) 53: 1392-1396 [PMID:20055417] |
| ChEMBL | Displacement of [3H]DAMGO from human opioid gamma receptor expressed in CHO cells | B | 9.1 | pKi | 0.79 | nM | Ki | J Med Chem (2007) 50: 2254-2258 [PMID:17407276] |
| ChEMBL | Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells | B | 9.18 | pKi | 0.66 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293] |
| ChEMBL | Displacement of [125I]-IBOxyA from MOR-1 expressed in CHO cells | B | 9.24 | pKi | 0.57 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4001-4004 [PMID:21621410] |
| ChEMBL | Displacement of [3H]DPN from human recombinant mu-type opioid receptor expressed in CHO cell membranes | B | 9.25 | pKi | 0.56 | nM | Ki | Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931] |
| ChEMBL | Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cells after 60 mins by scintillation counting | B | 9.64 | pKi | 0.23 | nM | Ki | Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470] |
| ChEMBL | Antagonist activity at human mu opioid receptor expressed in HEK293T cells assessed as Galphai2 activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay | F | 6.52 | pIC50 | 302 | nM | IC50 | J Med Chem (2021) 64: 7778-7808 [PMID:34011153] |
| ChEMBL | Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAMP level preincubated for 15 to 20 mins followed by DAMGO and forskolin addition by GloSensor assay | F | 7.02 | pIC50 | 94.84 | nM | IC50 | J Med Chem (2017) 60: 6733-6750 [PMID:28726402] |
| ChEMBL | Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAMP level preincubated for 15 to 20 mins followed by DAMGO and forskolin addition by GloSensor assay | F | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2017) 60: 6733-6750 [PMID:28726402] |
| ChEMBL | Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as inhibition of DAGO-stimulated [35S]GTPgammaS binding | F | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2007) 50: 2254-2258 [PMID:17407276] |
| ChEMBL | DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) | B | 7.7 | pIC50 | 20 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at human cloned mu opioid receptor assessed as inhibition of loperamide-stimulated [35S]GTP-gamma-S binding | F | 8.14 | pIC50 | 7.3 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2006-2012 [PMID:18313920] |
| ChEMBL | Concentration required to inhibit agonist (loperamide) stimulated [35S]GTP-gamma-S, binding to membranes containing the cloned human mu opioid receptor | F | 8.14 | pIC50 | 7.3 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 4459-4462 [PMID:14643346] |
| ChEMBL | Antagonist activity assessed as inhibition of loperamide-stimulated [35S]GTPgammaS binding to human mu opioid receptor expressed in CHO cells | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2006) 49: 7290-7306 [PMID:17149859] |
| ChEMBL | Antagonist activity against human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of loperamide-stimulated [35S]GTP-gamma-S binding | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2006) 49: 7278-7289 [PMID:17149858] |
| ChEMBL | Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligand | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2001) 44: 3378-3390 [PMID:11585443] |
| ChEMBL | Displacement of radiolabeled DAMGO from human recombinant mu opioid receptor expressed in OPRM1 cells | B | 8.73 | pIC50 | 1.87 | nM | IC50 | J Med Chem (2013) 56: 9045-9056 [PMID:24171469] |
| Mu opioid receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3041] [UniProtKB: P79350] | ||||||||
| ChEMBL | Inhibition of 0.5 nM [3H]- Bremazocine binding to Opioid receptor mu 1 of bovine striatum membrane | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (1990) 33: 2286-2296 [PMID:2165166] |
| μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] | ||||||||
| ChEMBL | Antagonist activity at mu opioid receptor in Swiss mouse vas deferens assessed as reversal of Sufentanil effect on electrically-induced driven twitch | F | 7.99 | pKd | 10.23 | nM | Kd | Bioorg Med Chem (2008) 16: 869-873 [PMID:17962026] |
| GtoPdb | - | - | 9 | pKi | - | - | - | Mol Pharmacol (1994) 45: 330-4 [PMID:8114680] |
| ChEMBL | Antagonist activity at mouse mu opioid receptor expressed in CHO cells cotransfected with Galphaqi5 assessed as inhibition of DAMGO-induced increase in intracellular calcium concentration preincubated for 60 mins in Fluo4AM solution followed by compound addition and further incubated for 15 mins followed by DAMGO stimulation by Fluo4AM dye based assay | F | 7.81 | pIC50 | 15.37 | nM | IC50 | J Med Chem (2019) 62: 11399-11415 [PMID:31782922] |
| μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] | ||||||||
| ChEMBL | Opioid receptor mu 2 affinity against the receptor site model site 2(mu2) | B | 8.3 | pKd | 5 | nM | Kd | J Med Chem (1986) 29: 531-537 [PMID:3007760] |
| ChEMBL | Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the cDNAs for rat Opioid receptor mu 1 | B | 8.52 | pKd | 3 | nM | Kd | Bioorg Med Chem Lett (2000) 10: 831-834 [PMID:10782696] |
| ChEMBL | Opioid receptor mu 1 affinity against the receptor site model site 1 (mu1) | B | 9.4 | pKd | 0.4 | nM | Kd | J Med Chem (1986) 29: 531-537 [PMID:3007760] |
| ChEMBL | Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenates | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (1993) 36: 2842-2850 [PMID:8410999] |
| ChEMBL | Binding affinity towards mu opioid receptor by displacement of [3H]NAL from rat brain homogenates | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (1993) 36: 2833-2841 [PMID:8410998] |
| ChEMBL | Tested for binding affinity towards mu receptor in presence of [3H]NAL radioligand | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (1994) 37: 2262-2265 [PMID:8057274] |
| ChEMBL | Displacement of [3H]-naloxone from rat mu opioid receptor expressed in HEK cells after 60 mins | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem (2014) 22: 4694-4703 [PMID:25087049] |
| ChEMBL | Inhibition of [3H]DAMGO binding to rat Opioid receptor mu 1 | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 523-526 [PMID:10741545] |
| ChEMBL | Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane. | B | 8.97 | pKi | 1.07 | nM | Ki | J Med Chem (1989) 32: 663-671 [PMID:2563773] |
| Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266] | ||||||||
| ChEMBL | Tested for its antagonist activity against mu receptor using DAMGO as radioligand in isolated guinea pig ileum | F | 8.5 | pKd | 3.16 | nM | Kd | J Med Chem (1994) 37: 2262-2265 [PMID:8057274] |
| ChEMBL | Negative logarithm of the molar concentration of Opioid receptor mu 1 was determined in guinea pig ileum | B | 8.73 | pKd | 1.86 | nM | Kd | Bioorg Med Chem Lett (2000) 10: 2745-2748 [PMID:11133082] |
| ChEMBL | Displacement of [3H]DAMGO from mu-type opioid receptor in guinea pig brain membranes after 120 mins by solid scintillation counting | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (2017) 60: 2526-2551 [PMID:28218838] |
| ChEMBL | Displacement of [3H]-DAMGO from mu opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5326-5330 [PMID:26411794] |
| ChEMBL | Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis | B | 8.68 | pKi | 2.1 | nM | Ki | Medchemcomm (2016) 7: 2368-2380 |
| ChEMBL | Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2019) 62: 4204-4217 [PMID:30939014] |
| ChEMBL | In vivo binding affinity against mu opioid receptor was measured by using labeled ligand [3H]naloxone (0.5 nM) | B | 8.96 | pKi | 1.1 | nM | Ki | J Med Chem (1994) 37: 3121-3127 [PMID:7932535] |
| ChEMBL | Affinity to mu-receptor, using [3H]DAMGO as radioligand in homogenates of guinea pig brain membranes | B | 9.17 | pKi | 0.68 | nM | Ki | J Med Chem (2001) 44: 2814-2826 [PMID:11495592] |
| ChEMBL | Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membrane | B | 9.17 | pKi | 0.68 | nM | Ki | Eur J Med Chem (2007) 42: 1247-1262 [PMID:17420073] |
| ChEMBL | Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membrane | B | 8.05 | pIC50 | 8.9 | nM | IC50 | J Med Chem (1992) 35: 4589-4594 [PMID:1335078] |
| ChEMBL | inhibition of 1.0 nM [3H]- DAGO binding to guinea pig brain membrane opioid receptor mu | B | 8.05 | pIC50 | 8.9 | nM | IC50 | J Med Chem (1992) 35: 2374-2384 [PMID:1320121] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | In vivo binding affinity against sigma Opioid receptor was measured by using labeled ligand [3H]-SKF- 10,047 (1 nM) | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (1994) 37: 3121-3127 [PMID:7932535] |
| ChEMBL | Inhibition of specific binding of [125I]-PIPAG to sigma binding site in Guinea pig brain membranes | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
| ChEMBL | Inhibition of specific binding of [3H]NANM of sigma binding site in Guinea pig brain membranes | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] | ||||||||
| ChEMBL | Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain homogenate | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2010) 53: 1392-1396 [PMID:20055417] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
