vidarabine [Ligand Id: 4806] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1090 (ARA-A, Arabinosyladenine, Arasena-a, CI 673, CI-673, NSC-247519, NSC-404241, NSC-757383, Vidarabine, Vidarabine anhydrous, Vidarabine, anhydrous, Vidarabine monohydrate, Vira-a)
  • S-Adenosylhomocysteine hydrolase/Adenosylhomocysteinase in Mouse [ChEMBL: CHEMBL2389] [GtoPdb: 1233] [UniProtKB: P50247]
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  • adenylyl cyclase 5/Adenylate cyclase type V in Rat [ChEMBL: CHEMBL2880] [GtoPdb: 1282] [UniProtKB: Q04400]
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  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
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  • Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S-Adenosylhomocysteine hydrolase/Adenosylhomocysteinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2389] [GtoPdb: 1233] [UniProtKB: P50247]
ChEMBL Activity determined in mouse liver S-adenosyl-L-homocysteine hydrolase and expressed as KI values. B 4.52 pKi 30000 nM Ki J Med Chem (1991) 34: 647-656 [PMID:1995889]
adenylyl cyclase 5/Adenylate cyclase type V in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2880] [GtoPdb: 1282] [UniProtKB: Q04400]
ChEMBL Compound was evaluated for inhibition of adenylate cyclase from rat brain B 4.09 pIC50 82000 nM IC50 J Med Chem (2004) 47: 1207-1213 [PMID:14971900]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of human DPP4 from human Caco-2 cells B 7.21 pIC50 62 nM IC50 J Med Chem (2010) 53: 559-572 [PMID:20000418]
Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8]
ChEMBL Inhibition HCV NS5B-mediated RNA synthesis F 4.3 pIC50 50000 nM IC50 J Med Chem (2004) 47: 2283-2295 [PMID:15084127]
ChEMBL Inhibition HCV RNA replication F 4.3 pEC50 >50000 nM EC50 J Med Chem (2004) 47: 2283-2295 [PMID:15084127]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]