vidarabine [Ligand Id: 4806] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1090 (Vidarabine, Arabinosyladenine, CI-673, NSC-404241, ARA-A, CI 673, NSC-247519, Vira-a, Vidarabine monohydrate)
  • S-Adenosylhomocysteine hydrolase/Adenosylhomocysteinase in Mouse [ChEMBL: CHEMBL2389] [GtoPdb: 1233] [UniProtKB: P50247]
There should be some charts here, you may need to enable JavaScript!
  • adenylyl cyclase 5/Adenylate cyclase type V in Rat [ChEMBL: CHEMBL2880] [GtoPdb: 1282] [UniProtKB: Q04400]
There should be some charts here, you may need to enable JavaScript!
  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
There should be some charts here, you may need to enable JavaScript!
  • Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S-Adenosylhomocysteine hydrolase/Adenosylhomocysteinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2389] [GtoPdb: 1233] [UniProtKB: P50247]
ChEMBL Activity determined in mouse liver S-adenosyl-L-homocysteine hydrolase and expressed as KI values. B 4.52 pKi 30000 nM Ki J. Med. Chem. (1991) 34: 647-656 [PMID:1995889]
adenylyl cyclase 5/Adenylate cyclase type V in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2880] [GtoPdb: 1282] [UniProtKB: Q04400]
ChEMBL Compound was evaluated for inhibition of adenylate cyclase from rat brain B 4.09 pIC50 82000 nM IC50 J. Med. Chem. (2004) 47: 1207-1213 [PMID:14971900]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of human DPP4 from human Caco-2 cells B 7.21 pIC50 62 nM IC50 J. Med. Chem. (2010) 53: 559-572 [PMID:20000418]
Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8]
ChEMBL Inhibition HCV NS5B-mediated RNA synthesis F 4.3 pIC50 50000 nM IC50 J. Med. Chem. (2004) 47: 2283-2295 [PMID:15084127]
ChEMBL Inhibition HCV RNA replication F 4.3 pEC50 >50000 nM EC50 J. Med. Chem. (2004) 47: 2283-2295 [PMID:15084127]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]