cipargamin [Ligand Id: 9721] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1082723 (Cipargamin, Cipargamina, Cipargamine, Kae609, KAE-609, KAE609, NITD-609, NITD-609, (+)-, NITD609)
  • phosphodiesterase 4D/3`,5`-cyclic-AMP phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT2B receptor/5-hydroxytryptamine receptor 2B in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT2C receptor/5-hydroxytryptamine receptor 2C in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT3A/5-hydroxytryptamine receptor 3A in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
There should be some charts here, you may need to enable JavaScript!
  • A2A receptor/Adenosine receptor A2a in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
There should be some charts here, you may need to enable JavaScript!
  • A3 receptor/Adenosine receptor A3 in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
There should be some charts here, you may need to enable JavaScript!
  • α1A-adrenoceptor/Alpha-1A adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
There should be some charts here, you may need to enable JavaScript!
  • α2A-adrenoceptor/Alpha-2A adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
There should be some charts here, you may need to enable JavaScript!
  • α2B-adrenoceptor/Alpha-2B adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
There should be some charts here, you may need to enable JavaScript!
  • α2C-adrenoceptor/Alpha-2C adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
There should be some charts here, you may need to enable JavaScript!
  • Monoamine oxidase A/Amine oxidase [flavin-containing] A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • B1 receptor/B1 bradykinin receptor in Human [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663]
There should be some charts here, you may need to enable JavaScript!
  • B2 receptor/B2 bradykinin receptor in Human [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
There should be some charts here, you may need to enable JavaScript!
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
There should be some charts here, you may need to enable JavaScript!
  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
There should be some charts here, you may need to enable JavaScript!
  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
There should be some charts here, you may need to enable JavaScript!
  • CB1 receptor/Cannabinoid receptor 1 in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
There should be some charts here, you may need to enable JavaScript!
  • CCK1 receptor/Cholecystokinin receptor type A in Human [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238]
There should be some charts here, you may need to enable JavaScript!
  • CRF1 receptor/Corticotropin-releasing factor receptor 1 in Human [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
There should be some charts here, you may need to enable JavaScript!
  • CRF2 receptor/Corticotropin-releasing factor receptor 2 in Human [ChEMBL: CHEMBL4069] [GtoPdb: 213] [UniProtKB: Q13324]
There should be some charts here, you may need to enable JavaScript!
  • D1 receptor/D(1A) dopamine receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
There should be some charts here, you may need to enable JavaScript!
  • D2 receptor/D(2) dopamine receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
There should be some charts here, you may need to enable JavaScript!
  • D3 receptor/D(3) dopamine receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
There should be some charts here, you may need to enable JavaScript!
  • D4 receptor/D(4) dopamine receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
There should be some charts here, you may need to enable JavaScript!
  • δ receptor/Delta-type opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
There should be some charts here, you may need to enable JavaScript!
  • ETA receptor/Endothelin-1 receptor in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
There should be some charts here, you may need to enable JavaScript!
  • ETB receptor/Endothelin receptor type B in Human [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
There should be some charts here, you may need to enable JavaScript!
  • Estrogen receptor-α/Estrogen receptor in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
There should be some charts here, you may need to enable JavaScript!
  • Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • GIP receptor/Gastric inhibitory polypeptide receptor in Rat [ChEMBL: CHEMBL5001] [GtoPdb: 248] [UniProtKB: P43219]
There should be some charts here, you may need to enable JavaScript!
  • CCK2 receptor/Gastrin/cholecystokinin type B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
There should be some charts here, you may need to enable JavaScript!
  • glucagon receptor/Glucagon receptor in Human [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • ghrelin receptor/Growth hormone secretagogue receptor type 1 in Human [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
There should be some charts here, you may need to enable JavaScript!
  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
There should be some charts here, you may need to enable JavaScript!
  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
There should be some charts here, you may need to enable JavaScript!
  • H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
There should be some charts here, you may need to enable JavaScript!
  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
There should be some charts here, you may need to enable JavaScript!
  • κ receptor/Kappa-type opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
There should be some charts here, you may need to enable JavaScript!
  • MC3 receptor/Melanocortin receptor 3 in Human [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968]
There should be some charts here, you may need to enable JavaScript!
  • MC4 receptor/Melanocortin receptor 4 in Human [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
There should be some charts here, you may need to enable JavaScript!
  • motilin receptor/Motilin receptor in Human [ChEMBL: CHEMBL2203] [GtoPdb: 297] [UniProtKB: O43193]
There should be some charts here, you may need to enable JavaScript!
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
There should be some charts here, you may need to enable JavaScript!
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
There should be some charts here, you may need to enable JavaScript!
  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
There should be some charts here, you may need to enable JavaScript!
  • μ receptor/Mu-type opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
There should be some charts here, you may need to enable JavaScript!
  • Y1 receptor/Neuropeptide Y receptor type 1 in Human [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
There should be some charts here, you may need to enable JavaScript!
  • Y2 receptor/Neuropeptide Y receptor type 2 in Human [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146]
There should be some charts here, you may need to enable JavaScript!
  • NTS1 receptor/Neurotensin receptor type 1 in Human [ChEMBL: CHEMBL4123] [GtoPdb: 309] [UniProtKB: P30989]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • COX-1 /Prostaglandin G/H synthase 1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
There should be some charts here, you may need to enable JavaScript!
  • COX-2 /Prostaglandin G/H synthase 2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
There should be some charts here, you may need to enable JavaScript!
  • DAT/Sodium-dependent dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
There should be some charts here, you may need to enable JavaScript!
  • NET/Sodium-dependent noradrenaline transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
There should be some charts here, you may need to enable JavaScript!
  • SERT/Sodium-dependent serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
There should be some charts here, you may need to enable JavaScript!
  • NK1 receptor/Substance-P receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
There should be some charts here, you may need to enable JavaScript!
  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
There should be some charts here, you may need to enable JavaScript!
  • AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
There should be some charts here, you may need to enable JavaScript!
  • V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
There should be some charts here, you may need to enable JavaScript!
  • V2 receptor/Vasopressin V2 receptor in Human [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
There should be some charts here, you may need to enable JavaScript!
  • Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum TM91C235 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum K1 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum NF54 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 3D7 [GtoPdb: 2971] [UniProtKB: A0A143ZZK9]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 7G8 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum D6 [GtoPdb: 2971]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 4D/3`,5`-cyclic-AMP phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL Binding affinity to human recombinant PDE4D B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to human recombinant serotonin 5-HT1A receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Binding affinity to human recombinant serotonin 5-HT2A receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT2B receptor/5-hydroxytryptamine receptor 2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Binding affinity to human recombinant serotonin 5-HT2B receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT2C receptor/5-hydroxytryptamine receptor 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Binding affinity to human recombinant serotonin 5HT2C receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT3A/5-hydroxytryptamine receptor 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Binding affinity to human recombinant serotonin 5HT3 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
A2A receptor/Adenosine receptor A2a in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Binding affinity to human recombinant adenosine 2a receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
A3 receptor/Adenosine receptor A3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Binding affinity to human recombinant adenosine 3 receptor B 5.08 pIC50 8300 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
α1A-adrenoceptor/Alpha-1A adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Binding affinity to human recombinant alpha 1a receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
α2A-adrenoceptor/Alpha-2A adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL Binding affinity to human recombinant alpha-2a receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
α2B-adrenoceptor/Alpha-2B adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL Binding affinity to human recombinant alpha2b receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
α2C-adrenoceptor/Alpha-2C adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL Binding affinity to human recombinant alpha2c receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Monoamine oxidase A/Amine oxidase [flavin-containing] A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL Binding affinity to human recombinant MAOM B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Androgen receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL Binding affinity to human recombinant androgen receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
B1 receptor/B1 bradykinin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663]
ChEMBL Binding affinity to human recombinant bradykinin B1 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
B2 receptor/B2 bradykinin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
ChEMBL Binding affinity to human recombinant bradykinin B2 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Binding affinity to human recombinant adrenergic beta-1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Binding affinity to human recombinant adrenergic beta2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL Binding affinity to human recombinant adrenergic beta3 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CB1 receptor/Cannabinoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Binding affinity to human recombinant cannabinoid 1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CCK1 receptor/Cholecystokinin receptor type A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238]
ChEMBL Binding affinity to human recombinant cholecystokinin A receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CRF1 receptor/Corticotropin-releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
ChEMBL Binding affinity to human recombinant CRF1 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CRF2 receptor/Corticotropin-releasing factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4069] [GtoPdb: 213] [UniProtKB: Q13324]
ChEMBL Binding affinity to human recombinant CRF2alpha receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
D1 receptor/D(1A) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL Binding affinity to human recombinant dopamine D1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
D2 receptor/D(2) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity to human recombinant dopamine D2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
D3 receptor/D(3) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Binding affinity to human recombinant dopamine D3 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
D4 receptor/D(4) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity to human recombinant dopamine D4.4 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
δ receptor/Delta-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL Binding affinity to human recombinant opiate delta receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ETA receptor/Endothelin-1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL Binding affinity to human recombinant endothelin A receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ETB receptor/Endothelin receptor type B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
ChEMBL Binding affinity to human recombinant endothelin B receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Estrogen receptor-α/Estrogen receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
ChEMBL Binding affinity to human recombinant ERalpha B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
ChEMBL Binding affinity to human recombinant ERbeta B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
GABAA receptor α1 subunit/GABAA receptor β1 subunit/GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor α2 subunit/GABAA receptor β2 subunit/GABAA receptor α4 subunit/GABAA receptor α6 subunit/GABA-A receptor; agonist GABA site in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2109244] [GtoPdb: 404, 410, 412, 408, 406, 405, 411, 407, 409] [UniProtKB: P14867, P18505, P28472, P31644, P34903, P47869, P47870, P48169, Q16445]
ChEMBL Binding affinity to human recombinant GABAA receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
GIP receptor/Gastric inhibitory polypeptide receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5001] [GtoPdb: 248] [UniProtKB: P43219]
ChEMBL Binding affinity to rat Gip receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CCK2 receptor/Gastrin/cholecystokinin type B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
ChEMBL Binding affinity to human recombinant cholecystokinin B receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
glucagon receptor/Glucagon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871]
ChEMBL Binding affinity to human recombinant glucagon receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL Binding affinity to human recombinant glucocorticoid receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5]
ChEMBL Binding affinity to human recombinant NMDA receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ghrelin receptor/Growth hormone secretagogue receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
ChEMBL Binding affinity to human recombinant Ghrelin receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL Binding affinity to human recombinant histamine H1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL Binding affinity to human recombinant histamine H2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL Binding affinity to human recombinant histamine H3 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
ChEMBL Binding affinity to human recombinant niacin receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
κ receptor/Kappa-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL Binding affinity to human recombinant opiate kappa receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
MC3 receptor/Melanocortin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968]
ChEMBL Binding affinity to human recombinant melanocortin MC3 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
MC4 receptor/Melanocortin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
ChEMBL Binding affinity to human recombinant melanocortin MC4 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
motilin receptor/Motilin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2203] [GtoPdb: 297] [UniProtKB: O43193]
ChEMBL Binding affinity to human recombinant motilin receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL Binding affinity to human recombinant muscarinic M1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL Binding affinity to human recombinant muscarinic M2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL Binding affinity to human recombinant muscarinic M3 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
μ receptor/Mu-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL Binding affinity to human recombinant opiate mu receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
ChEMBL Binding affinity to human recombinant neuropeptide Y1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146]
ChEMBL Binding affinity to human recombinant neuropeptide Y2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
NTS1 receptor/Neurotensin receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4123] [GtoPdb: 309] [UniProtKB: P30989]
ChEMBL Binding affinity to human recombinant neurotensin NT1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 I398F and P990R mutations after 72 hrs by SYBR green based fluorescence assay F 7.96 pIC50 10.9 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antiplasmodial activity against ring stage synchronized Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasitemia level after 48 hrs by flow cytometry relative to control F 8 pIC50 10 nM IC50 Eur J Med Chem (2014) 78: 375-382 [PMID:24699367]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring ATP4 P990R/D124Y double mutant F 8.35 pIC50 4.5 nM IC50 J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay F 8.37 pIC50 4.25 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD678-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 I203M and I263V mutations after 72 hrs by SYBR green based fluorescence assay F 8.39 pIC50 4.1 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay F 8.41 pIC50 3.9 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 T418N and P990R mutations after 72 hrs by SYBR green based fluorescence assay F 8.43 pIC50 3.7 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 D1247Y mutations after 72 hrs by SYBR green based fluorescence assay F 8.49 pIC50 3.2 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD678-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 A184S and P990Y mutations after 72 hrs by SYBR green based fluorescence assay F 8.55 pIC50 2.8 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD678-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 G223R mutations after 72 hrs by SYBR green based fluorescence assay F 8.55 pIC50 2.8 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay F 8.72 pIC50 1.89 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay F 8.8 pIC50 1.57 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 8.85 pIC50 1.4 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against pyrimethamine-resistant Plasmodium falciparum 7G8 after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 8.92 pIC50 1.2 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 after 48 hrs incubation by [3H]hypoxanthin incorporation assay F 9 pIC50 1 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing wild type ATP4 after 72 hrs by SYBR green based fluorescence assay F 9.04 pIC50 0.92 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against drug-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine assay F 9.05 pIC50 0.9 nM IC50 J Med Chem (2010) 53: 5155-5164 [PMID:20568778]
ChEMBL Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 F 9.05 pIC50 0.9 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against chloroquine, mefloquine and pyrimethamine-resistant Plasmodium falciparum TM91C235 after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 9.05 pIC50 0.9 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antiplasmodial activity against Plasmodium falciparum assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis F 9.05 pIC50 0.9 nM IC50 ACS Med Chem Lett (2013) 4: 989-993 [PMID:24159368]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and expressing parental ATP4 after 72 hrs by SYBR green based fluorescence assay F 9.07 pIC50 0.85 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs incubation by [3H]hypoxanthin incorporation assay F 9.15 pIC50 0.7 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against wild type Plasmodium falciparum Dd2 F 9.22 pIC50 0.6 nM IC50 J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 9.22 pIC50 0.6 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum K1 F 9.22 pIC50 0.6 nM IC50 Eur J Med Chem (2021) 210: 112955-112955 [PMID:33131885]
ChEMBL Antiplasmodial activity against asexual blood stage Plasmodium falciparum assessed as inhibition of parasitic growth F 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020]
ChEMBL Antimalarial activity against Plasmodium falciparum assessed as [35S]Met/Cys incorporation by SYBR green based fluorescence assay F 9.3 pIC50 0.5 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 after 48 hrs incubation by [3H]hypoxanthin incorporation assay F 9.3 pIC50 0.5 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 F 9.3 pIC50 0.5 nM IC50 Eur J Med Chem (2021) 210: 112955-112955 [PMID:33131885]
ChEMBL Antimalarial activity against chloroquine, mefloquine and pyrimethamine-resistant Plasmodium falciparum TM90C2A after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 9.3 pIC50 0.5 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in parasitemia incubated for 48 hrs by [3H]-hypoxanthine based liquid scintillation counting analysis F 9.3 pIC50 0.5 nM IC50 Eur J Med Chem (2023) 252: 115247-115247 [PMID:36931118]
ChEMBL Antiplasmodial activity against sexual blood stage Plasmodium falciparum assessed as inhibition of parasitic growth F 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green based fluorescence assay F 9.36 pIC50 0.44 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antiplasmodial activity against blood stage form of Plasmodium falciparum NF54 F 9 pEC50 1 nM EC50 J Med Chem (2013) 56: 7741-7749 [PMID:23927720]
ChEMBL Antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 F 9.15 pEC50 0.7 nM EC50 Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum TM90C2A infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum TM91C235 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum V1/S infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
COX-1 /Prostaglandin G/H synthase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Binding affinity to human recombinant COX1 B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
COX-2 /Prostaglandin G/H synthase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Binding affinity to human recombinant COX2 B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
DAT/Sodium-dependent dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL Binding affinity to human recombinant dopamine transporter B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
NET/Sodium-dependent noradrenaline transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Binding affinity to human recombinant norepinephrine transporter B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
SERT/Sodium-dependent serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Binding affinity to human recombinant serotonin transporter B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
NK1 receptor/Substance-P receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
ChEMBL Binding affinity to human recombinant neurokinin NK1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL Binding affinity to human recombinant thromboxane A2 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL Binding affinity to human recombinant angiotensin2 AT1 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL Binding affinity to human recombinant vasopressin V1a receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
ChEMBL Binding affinity to human recombinant vasopressin V2 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 4.52 pIC50 30440 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Inhibition of human ERG by patch clamp method B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Inhibition of human ERG by binding assay B 4.52 pIC50 >=30000 nM IC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Inhibition of human ERG by patch clamp method B 4.52 pIC50 >=30000 nM IC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum TM91C235 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 9.05 pIC50 0.9 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum K1 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 9.22 pIC50 0.6 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum NF54 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 9.3 pIC50 0.5 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 3D7 [GtoPdb: 2971] [UniProtKB: A0A143ZZK9]
GtoPdb Parasite growth inhibition assay - 9.15 pIC50 0.7 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 7G8 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 8.92 pIC50 1.2 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum D6 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 9 pIC50 1 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]