floxuridine [Ligand Id: 4801] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL917 (Fudr, 5-Fluoro-2-deoxyuridine, FUDR, NSC-27640, Floxuridine, F.u.d.r., Fluoruridine deoxyribose)
  • thymidylate synthetase/Thymidylate synthase in Mouse [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
thymidylate synthetase/Thymidylate synthase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607]
ChEMBL Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells. B 4.23 pIC50 59000 nM IC50 J. Med. Chem. (1996) 39: 4569-4575 [PMID:8917645]
ChEMBL Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells. B 4.96 pIC50 11000 nM IC50 J. Med. Chem. (1996) 39: 4569-4575 [PMID:8917645]
ChEMBL Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells. B 5.14 pIC50 7300 nM IC50 J. Med. Chem. (1996) 39: 4569-4575 [PMID:8917645]
ChEMBL Thymidylate synthase inhibition in thymidine kinase deficient LM cells after 2 hr treatment B 5.27 pIC50 5400 nM IC50 J. Med. Chem. (2001) 44: 4475-4480 [PMID:11728193]
ChEMBL Thymidylate synthase inhibition in wild type LM cells after 2 hr treatment B 6.59 pIC50 260 nM IC50 J. Med. Chem. (2001) 44: 4475-4480 [PMID:11728193]
ChEMBL Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells. B 7.37 pIC50 43 nM IC50 J. Med. Chem. (1996) 39: 4569-4575 [PMID:8917645]
ChEMBL Thymidylate synthase inhibition in thymidine kinase deficient /TK cells after 2 hr treatment B 7.7 pIC50 20 nM IC50 J. Med. Chem. (2001) 44: 4475-4480 [PMID:11728193]
ChEMBL Thymidylate synthase inhibition in L1210 mouse leukemia cells after 2 hr treatment B 8.1 pIC50 7.9 nM IC50 J. Med. Chem. (2001) 44: 4475-4480 [PMID:11728193]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 hrs by liquid scintillation counting B 9.15 pIC50 0.7 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24 hrs by liquid scintillation counting B 9.15 pIC50 0.7 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 mins by liquid scintillation counting B 9.22 pIC50 0.6 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15 mins by liquid scintillation counting B 9.22 pIC50 0.6 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 hrs by liquid scintillation counting B 9.4 pIC50 0.4 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 hrs by liquid scintillation counting B 9.4 pIC50 0.4 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]