ChEMBL ligand: CHEMBL917 (5-Fluoro-2-deoxyuridine, 5-fudr, Floxuridine, Fluoruridine deoxyribose, F.u.d.r., Fudr, FUDR, NSC-27640)
thymidylate synthetase/Thymidylate synthase in Mouse [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
thymidylate synthetase/Thymidylate synthase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607]
ChEMBL	Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells.	B	4.23	pIC50	59000	nM	IC50	J Med Chem (1996) 39: 4569-4575 [PMID:8917645]
ChEMBL	Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells.	B	4.96	pIC50	11000	nM	IC50	J Med Chem (1996) 39: 4569-4575 [PMID:8917645]
ChEMBL	Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.	B	5.14	pIC50	7300	nM	IC50	J Med Chem (1996) 39: 4569-4575 [PMID:8917645]
ChEMBL	Thymidylate synthase inhibition in thymidine kinase deficient LM cells after 2 hr treatment	B	5.27	pIC50	5400	nM	IC50	J Med Chem (2001) 44: 4475-4480 [PMID:11728193]
ChEMBL	Thymidylate synthase inhibition in wild type LM cells after 2 hr treatment	B	6.59	pIC50	260	nM	IC50	J Med Chem (2001) 44: 4475-4480 [PMID:11728193]
ChEMBL	Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.	B	7.37	pIC50	43	nM	IC50	J Med Chem (1996) 39: 4569-4575 [PMID:8917645]
ChEMBL	Thymidylate synthase inhibition in thymidine kinase deficient /TK cells after 2 hr treatment	B	7.7	pIC50	20	nM	IC50	J Med Chem (2001) 44: 4475-4480 [PMID:11728193]
ChEMBL	Thymidylate synthase inhibition in L1210 mouse leukemia cells after 2 hr treatment	B	8.1	pIC50	7.9	nM	IC50	J Med Chem (2001) 44: 4475-4480 [PMID:11728193]
ChEMBL	Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 hrs by liquid scintillation counting	B	9.15	pIC50	0.7	nM	IC50	Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL	Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24 hrs by liquid scintillation counting	B	9.15	pIC50	0.7	nM	IC50	Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL	Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 mins by liquid scintillation counting	B	9.22	pIC50	0.6	nM	IC50	Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL	Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15 mins by liquid scintillation counting	B	9.22	pIC50	0.6	nM	IC50	Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL	Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 hrs by liquid scintillation counting	B	9.4	pIC50	0.4	nM	IC50	Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL	Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 hrs by liquid scintillation counting	B	9.4	pIC50	0.4	nM	IC50	Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]