compound 8a [PMID: 22861813] [Ligand Id: 7891] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3145341
  • Cathepsin A/Lysosomal protective protein in Human [ChEMBL: CHEMBL6115] [GtoPdb: 1581] [UniProtKB: P10619]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cathepsin A/Lysosomal protective protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6115] [GtoPdb: 1581] [UniProtKB: P10619]
GtoPdb - - 7.42 pIC50 38 nM IC50 J Med Chem (2012) 55: 7636-49 [PMID:22861813]
ChEMBL Inhibition of human recombinant Myc-His10-tagged cathepsin A expressed in baculovirus infected Sf9 cells using BodipyFL labeled bradykinin as substrate incubated for 15 mins prior to substrate addition measured after 15 mins by fluorimetric analysis B 7.42 pIC50 38 nM IC50 J. Med. Chem. (2012) 55: 7636-7649 [PMID:22861813]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]