Compound class:
Synthetic organic
Comment: PF-07304814 is a SARS-CoV-2 3CL protease (Mpro) inhibitor from Pfizer. The phosphate group (which improves solubility) is cleaved in vitro to release the active antiviral PF-00835231 (reported in this bioRxiv preprint [1]). PF-00835231 was originally developed as a SARS-CoV-1 Mpro inhibitor in response to the 2002-2003 outbreak (ChemRxiv preprint [2]). Like remdesivir, PF-07304814 is administered by intravenous infusion.
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Classification ![]() |
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Compound class | Synthetic organic |
Is prodrug? | Yes |
Active form | PF-00835231 |
IUPAC Name ![]() |
[(3S)-3-[(2S)-2-[(4-methoxy-1H-indol-2-yl)formamido]-4-methylpentanamido]-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butoxy]phosphonic acid |
Database Links ![]() |
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GtoPdb PubChem SID | 434122309 |
Search Google for chemical match using the InChIKey | FQKALOFOWPDTED-WBAXXEDZSA-N |
Search Google for chemicals with the same backbone | FQKALOFOWPDTED |
Search UniChem for chemical match using the InChIKey | FQKALOFOWPDTED-WBAXXEDZSA-N |
Search UniChem for chemicals with the same backbone | FQKALOFOWPDTED |