Synonyms: example 63 [WO2019149738A1]
Compound class:
Synthetic organic
Comment: This is the chemical structure for the INN darizmetinib. This structure is claimed in HepaRegeniX's patent WO2019149738A1, as a mitogen-activated protein kinase kinase 4 (MKK4) inhibitor [1]. We suspect that darizmetinib is HepaRegeniX's lead MKK4 inhibitor HRX-0215, that has entered phase 1 clinical trial, although name>structure for HRX-0215 has not been formally disclosed (Feb 2023). MKK4 is a key regulator of liver regeneration. Inhibition of MKK4 promotes the regenerative capacity of hepatocytes.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Classification ![]() |
|
Compound class | Synthetic organic |
IUPAC Name ![]() |
N-[2,6-difluoro-3-(5-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl]propane-1-sulfonamide |
International Nonproprietary Names ![]() |
|
INN number | INN |
12490 | darizmetinib |
Synonyms ![]() |
example 63 [WO2019149738A1] |
Database Links ![]() |
|
CAS Registry No. | 2369583-33-3 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL4795907 |
GtoPdb PubChem SID | 479821167 |
PubChem CID | 139369660 |
Search Google for chemical match using the InChIKey | WBNMARNYIFMNEP-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | WBNMARNYIFMNEP |
Search PubMed clinical trials | darizmetinib |
Search PubMed titles | darizmetinib |
Search PubMed titles/abstracts | darizmetinib |
UniChem Compound Search for chemical match using the InChIKey | WBNMARNYIFMNEP-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | WBNMARNYIFMNEP-UHFFFAOYSA-N |